2026-04-04T01:51:11Z https://www.journal-jps.com/index.php/jps/oai

oai:ojs2.journal-jps.com:article/1 2021-03-04T15:44:27Z jps:ART driver

UJI EFEKTIVITAS FLAVONOID TOTAL EKSTRAK ETANOL KULIT BATANG NANGKA (Artocarpus heterophyllus Lam) TERHADAP PENYEMBUHAN LUKA SAYAT PADA AYAM BROILER (Gallus domesticus) THE EFFECTIVENESS OF TOTAL FLAVONOID EFFECT OF ETHANOL EXTRACTS OF NANGKA STONE (Artocarpus heterophyllus Lam) ON HEALING OF PASS Wounds IN BROILER CHICKEN (Gallus domesticus) Kemalasari, Nurisma Sumardi, Sumardi Febriani, Yessi Jackfruit (Artocarpus heterophyllus Lam) is a local plant found in various regions in Indonesia. This jackfruit tree is usually used as traditional medicine. This study aims to examine the ethanol extract of jackfruit bark against wound healing on broiler skin and determination of total flavonoid content using the calorimetry method. This study began with identification of plants, taking jackfruit bark, processing of jackfruit bark simplicia, making ethanol extract of jackfruit bark (Artocarpus heterophyllus Lam), measuring the total flavonoid content of ethanol extract of jackfruit bark, preparation of test animals, wound cutting on chicken skin, effectiveness test of total flavonoid ethanol extract of jackfruit bark (Artocarpus heterophyllus Lam) on wound healing in broiler chickens (Gallus domesticus), data analysis. The results showed that the administration of ethanol extract of jackfruit bark (Artocarpus heterophyllus Lam) to wound healing on the skin of broiler chickens (Gallus domesticus) had a better healing effect than negative controls. The results of applying 4 times in 24 hours provide the fastest healing effect on cuts on the skin of broiler chickens (Gallus domesticus). Based on statistical results there are 86.1% of flavonoids that affect the area of the curve and affect the healing of the area of incisions in chickens.         Nangka (Artocarpus heterophyllus Lam) merupakan tumbuhan lokal yang terdapat di berbagai daerah di Indonesia. Pohon nangka ini biasanya dimanfaatkan sebagai obat tradisional. Penelitian ini bertujuan untuk menguji ekstrak etanol kulit batang nangka terhadap penyembuhan luka sayat pada kulit ayam broiler dan penetapan kadar flavonoid total menggunakan metode kalorimetri.Penelitian ini dimulai dengan identifikasi tumbuhan, pengambilan kulit batang nangka, pengolahan simplisia kulit batang nangka, pembuatan ekstrak etanol kulit batang nangka (Artocarpus heterophyllus Lam), pengukuran kandungan flavonoid total ekstrak etanol kulit batang nangka, penyiapan hewan uji, penyayatan luka pada kulit ayam, uji efektivitas flavonoid total ekstrak etanol kulit batang nangka (Artocarpus heterophyllus Lam) terhadap penyembuhan luka sayat pada ayam broiler (Gallus domesticus), analisis data. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol kulit batang nangka (Artocarpus heterophyllus Lam) terhadap penyembuhan luka sayat pada kulit ayam broiler (Gallus domesticus) memberikan efek daya penyembuhan yang lebih baik dari kontrol negatif. Hasil pengolesan 4 kali dalam 24 jam paling cepat memberikan efek penyembuhan terhadap luka sayat pada kulit ayam broiler (Gallus domesticus). Berdasarkan hasil statistik terdapat 86,1% flavonoid yang mempengaruhi luas kurva dan mempengaruhi kesembuhan luas luka sayat pada ayam. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-02-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/1 10.36490/journal-jps.com.v1i1.1 Journal of Pharmaceutical And Sciences; Vol 1 No 1 (2018): JPS Volume 1 Nomor 1 (2018); 1-6 2656-3088 10.36490/journal-jps.com.v1i1 ind https://www.journal-jps.com/index.php/jps/article/view/1/6 10.36490/journal-jps.com.v1i1.1.g6 Copyright (c) 2018 Nurisma Kemalasari

oai:ojs2.journal-jps.com:article/2 2021-03-04T15:44:27Z jps:ART driver

Total Plate Count Analysis Of Tuna Fish Adulterated With Lard In Order To Improve Halal Products Analisis Total Mikroba Ikan Tuna Yang Diadulterasi Dengan Lemak Babi Dalam Rangka Meningkatkan Produk Halal Taufik, Muhammad Ardilla, Desi Razali, Mariany Sinaga, Maya Handayana Indonesia is the country with the largest level of Muslim population in the world. Guarantees for the safety and protection of consumers in the food sector must be considered. One of the parameters used in product halal is total microbial analysis. The sample used was processed tuna which is adulterated with lard (1: 1). The research method uses Factorial Completely Randomized Design method which consists of two factors, Factor I: Solvent Concentration (K) consists of 4 levels, namely: K1 = 20%, K2 = 30%, K3 = 40%, K4 = 50%, Factors II: Maseration Time (W) consists of 4 levels : W1 = 06 Hours, W2 = 12 Hours, W3 = 18 Hours, and W4 = 24 Hours. The results showed that the n-hexane concentration had a very significant effect (p <0.01) on the total microbial parameters. The highest total microbes were in the 50% (K4) concentration of 4,337 log CFU / ml (2.2x104 CFU / ml) and the lowest value was in the treatment concentration of 20% (K1) which was 4,216 log CFU / ml (1.7x104 CFU / ml). The average microbial total value in the treatment of solvent concentration (K) obtained was 2.0x104 CFU / ml. The treatment of maceration time also gave a very significant effect (p <0.01) on the total microbial parameters. The highest total microbial was 24 hours treatment = 4,410 log CFU / ml (2,6x104 CFU / ml) and the lowest value was at 6 hours treatment which was 4,173 log CFU / ml (1.5x104 CFU / ml). Total microbial analysis provides information on adulteration of lard in processed food products in support of halal certification Indonesia merupakan Negara dengan tingkat populasi Muslim terbesar di dunia Jaminan akan keamanan dan perlindungan konsumen dalam bidang pangan harus sangat diperhatikan. Salah satu parameter yang digunakan dalam kehalalan produk adalah Analisis total mikroba. Sampel yang digunakan adalah ikan tuna olahan yang diadulterasi dengan lemak babi (1 : 1). Metode penelitian menggunakan metode Rancangan Acak Lengkap Factorial yang terdiri dari dua faktor yaitu : Faktor I : Konsentrasi Pelarut (K) terdiri dari 4 taraf yaitu: K1 = 20%, K2 = 30%, K3 = 40%, K4= 50%, Faktor II : Waktu Maserasi  (W) terdiri dari 4 taraf yaitu : W1= 06 Jam, W2 = 12 Jam, W3 = 18 Jam, dan W4 = 24 Jam. Hasil Penelitian menunjukkan bahwa konsentrasi n-heksan memberikan pengaruh yang berbeda sangat nyata (p<0,01) terhadap parameter total mikroba. Total mikroba tertinggi berada pada perlakuan konsentrasi 50% (K4) yakni 4,337 log CFU/ml (2,2x104 CFU/ml) dan nilai terendah berada pada perlakuan konsentrasi 20% (K1) yakni 4,216 log CFU/ml (1,7x104 CFU/ml). Nilai rata-rata total mikroba pada perlakuan konsentrasi pelarut (K) yang diperoleh yaitu 2,0x104 CFU/ml. Perlakuan waktu maserasi juga memberikan pengaruh yang berbeda sangat nyata (p<0,01) terhadap parameter total mikroba. Total mikroba tertinggi berada pada perlakuan 24 jam yaitu 4,410 log CFU/ml (2,6x104 CFU/ml) dan nilai terendah berada pada perlakuan 6 jam yakni sebesar 4,173 log CFU/ml (1,5x104 CFU/ml).Analisis Total mikroba memberikan informasi adulterasi lemak babi dalam produk pangan olahan dalam mendukung sertifikasi halal. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-02-14 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/2 10.36490/journal-jps.com.v1i1.2 Journal of Pharmaceutical And Sciences; Vol 1 No 1 (2018): JPS Volume 1 Nomor 1 (2018); 7-15 2656-3088 10.36490/journal-jps.com.v1i1 ind https://www.journal-jps.com/index.php/jps/article/view/2/5 10.36490/journal-jps.com.v1i1.2.g5 Copyright (c) 2018 MUhammad Taufik

oai:ojs2.journal-jps.com:article/3 2021-03-04T15:44:27Z jps:ART driver

UJI AKTIVITAS ANTIINFLAMASI EKSTRAK AIR DAUN SALAM (Sygyzium polyanthum Wight.) TERHADAP TIKUS WISTAR JANTAN YANG DIINDUKSI DENGAN KARAGENAN 1% UJI AKTIVITAS ANTIINFLAMASI EKSTRAK AIR DAUN SALAM (Sygyzium polyanthum Wight.) TERHADAP TIKUS WISTAR JANTAN YANG DIINDUKSI DENGAN KARAGENAN 1% Hasanah, Fenny Hidayah, Nurul Inflammation is a local reaction of an organism to an irritant or non-physiological state. Existing anti-inflammatory treatments have many side effects if used for a long time. Indonesian people have known and made bay leaves as anti-inflammatory drugs. The purpose of this study was to determine the antiinflammatory activity of bay leaf water extract (Sygyzium polyanthum Wight.) On the feet of male Wistar rats which were induced by carrageenan 1%. The research method used is experimental. The data obtained were analyzed by SPSS 20.0 ANOVA method at a confidence level of 95%. The results of the characteristics of the bay leaf simplicia showed that the water content was 6.6%, the water soluble extract content was 35%, the soluble extract content of ethanol was 21%. The antiinflammatory test results, observed by the percentage of inflammation in the induction group, had the highest percentage of inflammation compared to the other test groups at minute (T300). Whereas in the percentage of inflammation inhibition, all groups of test extracts have effectiveness that is comparable to the comparison group at (T300). EADS group 50 mg / kgbb is the best dose of extract as anti-inflammatory at (T300) where flavonoid compounds are thought to be responsible for decreasing the volume of inflammation in the legs of test animals. Inflamasi merupakan suatu reaksi lokal organisme terhadap suatu iritasi atau keadaan non fisiologis. Pengobatan antiinflamasi yang ada memiliki banyak efek samping jika dipakai dalam waktu yang lama. Masyarakat Indonesia telah mengenal dan menjadikan daun salam sebagai obat antiinflamasi. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antiinflamasi ekstrak air daun salam (Sygyzium polyanthum Wight.) pada telapak kaki tikus Wistar jantan yang diinduksi karagenan 1%. Metode penelitian yang digunakan adalah eksperimental. Data yang diperoleh dianalisis dengan SPSS 20.0 metode ANOVA pada tingkat kepercayaan 95%. Hasil dari karakteristik simplisia daun salam menunjukkan bahwa kadar air 6,6%, kadar sari larut air 35%, kadar sari larut etanol 21%. Hasil uji antiinflamasi, pada pengamatan persen radang kelompok induksi memiliki persen radang yang paling tinggi dibandingkan dengan kelompok uji lainnya pada menit ke (T300), sedangkan pada persen inhibisi radang, semua kelompok ekstrak uji memiliki efektivitas yang sebanding dengan kelompok pembanding pada (T300). Kelompok EADS 50 mg/kgbb merupakan dosis ekstrak terbaik sebagai antiinflamasi pada (T300) dimana senyawa flavonoid diperkirakan bertanggung jawab terhadap penurunan volume radang kaki hewan uji Fakultas Farmasi Universitas Tjut Nyak Dhien 2018-07-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/3 10.36490/journal-jps.com.v1i1.3 Journal of Pharmaceutical And Sciences; Vol 1 No 1 (2018): JPS Volume 1 Nomor 1 (2018); 16-22 2656-3088 10.36490/journal-jps.com.v1i1 ind https://www.journal-jps.com/index.php/jps/article/view/3/4 10.36490/journal-jps.com.v1i1.3.g4 Copyright (c) 2018 Fenny Hasanah

oai:ojs2.journal-jps.com:article/4 2021-03-04T15:44:27Z jps:ART driver

CONSUMER PERCEPTION OF SERVICES PHARMACY IN BINJAI CITY PERSEPSI KONSUMEN TERHADAP PELAYANAN APOTEK DI KECAMATAN BINJAI KOTA Dasopang, Eva Sartika Sari, Intan Purnama A pharmacy is a pharmacy service facility conducted by pharmacists. Pharmaceutical services a direct and responsible service to patients related to pharmaceutical preparations with the aim of achieving definite results to improve the quality of life of patients. This study aims to determine the pharmacy consumer's perception of pharmacy services and the level of customer satisfaction with the pharmacy services in Binjai City District. The method used in this study is descriptive survey research that is cross-sectional. The research data collection was carried out at the Pharmacy located in Binjai City District in June-July 2017. Samples taken were 313 people. Data analysis used Statistical Product and Service Solutions (SPSS) program with Chi Square test method. The test parameters in this study are reliability, responsiveness, confidence, empathy and tangible facilities. The results showed that the consumers' perceptions of Apotek on Pharmacy services in Binjai Kota District obtained an average of 36.45 of total customer satisfaction with a satisfied category. The results of the level of customer satisfaction in the pharmacy based on variables of reliability, responsiveness, confidence, empathy and tangible facilities are in the satisfied category of 77.3%, 78.6%, 53.0%, 71.9% and 83.1%. The results of the influence of the characteristics of age, education and consumer work on consumer satisfaction using the Chi Square Test showed a significant effect (P <0.05). Consumer perceptions of the pharmacy service in Binjai Kota District include the satisfied category. The level of consumer satisfaction with the pharmacy services in Binjai City District includes the satisfied category. Apotek adalah sarana pelayanan kefarmasian tempat dilakukan praktik kefarmasian oleh Apoteker. Pelayanan kefarmasian suatu pelayanan langsung dan bertanggung jawab kepada pasien yang berkaitan dengan sediaan farmasi dengan maksud mencapai hasil yang pasti untuk meningkatkan mutu kehidupan pasien. Penelitian ini bertujuan untuk mengetahui persepsi konsumen apotek terhadap pelayanan apotek dan tingkat kepuasan konsumen terhadap pelayanan apotek di Kecamatan Binjai Kota. Metode yang digunakan pada penelitian ini adalah penelitian survei deskriptif yang bersifat cross-sectional. Pengambilan data penelitian dilaksanakan di Apotek yang berada di Kecamatan Binjai Kota pada bulan Juni-Juli 2017. Sampel yang diambil sebesar 313 orang. Analisis data menggunakan program Statistical Product and Service Solutions (SPSS) dengan metode uji Chi Square. Parameter uji dalam penelitian ini adalah kehandalan, ketanggapan, keyakinan, empati dan fasilitas berwujud. Hasil penelitian menunjukkan bahwa persepsi konsumen Apotek terhadap pelayanan Apotek di Kecamatan Binjai Kota memperoleh rata-rata sebesar 36,45 dari total kepuasan konsumen dengan kategori puas. Hasil tingkat kepuasan konsumen di apotek berdasarkan variabel kehandalan, ketanggapan, keyakinan, empati dan fasilitas berwujud  berada pada kategori puas yaitu 77,3%, 78,6%, 53,0%, 71,9% dan 83,1%. Hasil pengaruh karakteristik umur, pendidikan dan pekerjaan konsumen terhadap kepuasan konsumen dengan menggunakan uji Chi Square Test menunjukkan pengaruh yang signifikan (P< 0,05). Persepsi konsumen terhadap pelayanan apotek di Kecamatan Binjai Kota termasuk kategori puas. Tingkat kepuasan konsumen terhadap pelayanan apotek di Kecamatan Binjai Kota termasuk kategori puas. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-02-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/4 10.36490/journal-jps.com.v1i1.4 Journal of Pharmaceutical And Sciences; Vol 1 No 1 (2018): JPS Volume 1 Nomor 1 (2018); 23-31 2656-3088 10.36490/journal-jps.com.v1i1 ind https://www.journal-jps.com/index.php/jps/article/view/4/3 10.36490/journal-jps.com.v1i1.4.g3 Copyright (c) 2018 Eva Sartika Dasopang

oai:ojs2.journal-jps.com:article/5 2021-03-04T15:44:27Z jps:ART driver

DETERMINATION OF CALCIUM AND IRON METAL IN KELOR LEAF (Moringa oleifera Lam) by Using ATOMIC ABSORPTION SPECTROPHOTOMETRY PENETAPAN KADAR LOGAM KALSIUM DAN BESI PADA DAUN KELOR (Moringa oleifera Lam) DENGAN SPEKTROFOTOMETER SERAPAN ATOM Asra, Ridho Harefa, Festires Kurnia Zulharmita, Zulharmita Nessa, Nessa The determination of calcium and iron metal in moringa leaf sample obtained from Purus area, Padang Barat has been done. In this study, the destruction method that has been used was wet destruction, the result of this method was determined with atomic absorption spectrophotometer by using Ca and Fe hallow cathode lamp. Based on the result of this study, a linear regression equation of calcium standard solution which was y = 0,03818 + 0,17036x, with r = 0,9997 and a linear regression equation of iron standard solution which was y = 0,03831 + 0,064275x, with r = 0,9986. The limit of detection (LOD) and the limit of quantitation (LOQ) of calcium was 0,0678 mg/kg and 0,2261 mg/kg and then the limit of detection (LOD) and the limit of quantitation (LOQ) of iron was 0,5790 mg/kg and 1,9292 mg/kg. The results of the determination of calcium content in moringa leaf with three replications were 1277,986 mg/kg, 1269,178 mg/kg, 1229,063 mg/kg so that the average calcium content in the moringa leaf was 1258,742 mg/kg. The results of the determination of iron content in moringa leaf with three replications were 210,509 mg/kg, 198,985 mg/kg, 206,117 mg/kg so that the average iron content in moringa leaf was 205,204 mg/kg. Telah dilakukan penetapan kadar logam kalsium dan besi pada sampel daun kelor yang diperoleh dari daerah Purus, Kecamatan Padang Barat. Dalam penelitian ini proses destruksi yang digunakan adalah destruksi basah. Hasil dari destruksi ini selanjutnya diukur dengan spektrofotometer serapan atom menggunakan lampu katoda berongga Ca dan Fe sebagai sumber cahaya. Berdasarkan hasil penelitian didapatkan garis regresi linier dari larutan standar kalsium dengan persamaan y = 0,03818 + 0,17036x, dengan r = 0,9997, sedangkan untuk larutan standar besi didapatkan y = 0,03831 + 0,064275x, dengan r = 0,9986. Nilai batas deteksi (BD) dan batas kuantitasi (BK) dari kalsium yaitu 0,0678 mg/kg dan 0,2261 mg/kg, sedangkan nilai batas deteksi (BD) dan batas kuantitasi (BK) dari besi yaitu 0,5790 mg/kg dan 1,9292 mg/kg. Dari persamaan garis regresi linier tersebut diperoleh kadar kalsium dalam daun kelor dengan tiga kali pengulangan yaitu 1277,986 mg/kg, 1269,178 mg/kg, 1229,063 mg/kg sehingga rata-rata kandungan kalsium dalam daun kelor yaitu 1258,742 mg/kg. Sedangkan, hasil dari penetapan kadar besi dalam daun kelor dengan tiga kali pengulangan yaitu 210,509 mg/kg, 198,985 mg/kg, 206,117 mg/kg sehingga rata-rata kandungan besi dalam daun kelor yaitu 205,204 mg/kg Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-02-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/5 10.36490/journal-jps.com.v1i1.5 Journal of Pharmaceutical And Sciences; Vol 1 No 1 (2018): JPS Volume 1 Nomor 1 (2018); 32-38 2656-3088 10.36490/journal-jps.com.v1i1 ind https://www.journal-jps.com/index.php/jps/article/view/5/2 10.36490/journal-jps.com.v1i1.5.g2 Copyright (c) 2018 Ridho Asra

oai:ojs2.journal-jps.com:article/6 2021-03-04T15:44:27Z jps:ART driver

DETERMINATION OF PHOSPHORUS CONTENT IN GREEN OKRA (Abelmoschus esculentus (L.) Moench) USING VISIBLE SPECTROPHOTOMETRY UJI EFEKTIVITAS FLAVONOID TOTAL EKSTRAK ETANOL KULIT BATANG NANGKA PENETAPAN KADAR FOSFOR DALAM OKRA HIJAU (Abelmoschus esculentus (L.) Moench) SECARA SPEKTROFOTOMETRI SINAR TAMPAK Saputri, Muharni Gunawan, Muhammad Maghfirah, Maizatun Green Okra is one vegetable that contains minerals is quite high. One such mineral is phosphorus, which is an essential mineral needed for growth and repair of cells in the body. This study aims to determine the levels of phosphorus in raw green okra, steamed, and stew as commonly consumed by people. The research method using wet digestion analysis and measurement with visible spectrophotometry with the addition of phosphorus reagent color developer which is a mixture ammonium molibdat 4%, ascorbic acid 0.1 N, antimonil potassium tartrate, and 5N sulfuric acid produces a blue color and is measured at a wavelength of 722, 50 nm with the working time in the 30th minute to the 38th minute. Levels of phosphorus obtained from raw green okra 62.115 mg / 100 g, steamer 60.130 mg / 100 g, Okra hijau merupakan salah satu sayuran yang mengandung mineral cukup tinggi. Salah satu mineral tersebut adalah fosfor, yaitu mineral esensial yang dibutuhkan untuk pertumbuhan dan perbaikan sel-sel di dalam tubuh. Penelitian ini bertujuan untuk menentukan kadar fosfor pada okra hijau mentah, kukusan, dan rebusan sebagaimana lazimnya dikonsumsi oleh masyarakat. Metode penelitian dengan menggunakan analisis destruksi basah dan pengukuran dengan spektrofotometri sinar tampak dengan penambahan pereaksi pengembang warna fosfor yaitu campuran amoniummolibdat 4%, asam askorbat 0,1 N, kalium antimonil tartrat, dan asam sulfat 5N menghasilkan warna biru dan diukur pada panjang gelombang 722,50 nm dengan waktu kerja pada menit ke-30 hingga menit ke-38. Kadar fosfor yang diperoleh dari okra hijau mentah 62,115 mg/100 g, kukusan 60,130 mg/100 g, dan rebusan 60,040 mg/100 g, dengan hasil validasi diperoleh persen perolehan kembali pada batas penerimaan yang baik sebesar 100,42% dengan presisi (RSD) 1,00%, dan batas deteksi (LOD) 0,0175 μg/ml dan batas kuantitasi (LOQ) 0,0584μg/ml. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-02-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/6 10.36490/journal-jps.com.v1i1.6 Journal of Pharmaceutical And Sciences; Vol 1 No 1 (2018): JPS Volume 1 Nomor 1 (2018); 39-44 2656-3088 10.36490/journal-jps.com.v1i1 ind https://www.journal-jps.com/index.php/jps/article/view/6/1 10.36490/journal-jps.com.v1i1.6.g1 Copyright (c) 2018 Muharni Saputri

oai:ojs2.journal-jps.com:article/7 2023-07-17T14:04:08Z jps:ART driver

oai:ojs2.journal-jps.com:article/9 2023-07-17T14:04:12Z jps:ART driver

oai:ojs2.journal-jps.com:article/10 2021-03-04T15:44:27Z jps:ART driver

FORMULATION AND EVALUATION OF TRANSPARENT SOAP FROM BONE COW COLLAGEN (Bos sp.) AS MOISTURIZER FORMULASI DAN EVALUASI SABUN TRANSPARAN DARI KOLAGEN TULANG SAPI (Bos sp.) SEBAGAI PELEMBAB Zebua, Nilsya Febrika Sudewi, Sudewi Prihatini, Masrina Collagen is one of the proteins that make up the body or the organic structure that builds bones, teeth, joints, muscles, and skin. Collagen is very often used by the community because it is to maintain healthy skin and maintain skin elasticity. This study aims to determine collagen from bovine bones can be formulated into transparent soap preparations. Bovine bone collagen (Bos sp.) was extracted by immersion using 1N NaOH. The production of transparent soap formulas in several concentrations is 0.5%, 1%, 2.5%, and 5% collagen. The bovine bone collagen yield was obtained 27.5%. Collagen in a variety of concentrations produces different colors and the ability to moisturize the skin. Bovine bone collagen (Bos sp.) was formulated in transparent soap preparations from bovine bone collagen (Bos sp.) with a concentration of 0.5% including the category "moist" and transparent soap preparation from bovine bone collagen (Bos sp.) 1% , 2.5%, and 5% including the category of "very humid" and the results of testing on volunteers showed that transparent soap from collagen in bovine bone (Bos sp.) did not cause irritation. Kolagen adalah salah satu protein penyusun tubuh atau struktur organik pembangun tulang, gigi, sendi, otot, dan kulit. Kolagen sangat sering digunakan masyarakat karena demi menjaga kesehatan kulit dan memelihara elastisitas kulit. Penelitian ini bertujuan untuk mengetahui kolagen dari tulang sapi dapat diformulasikan kedalam sediaan sabun transparan. Kolagen tulang sapi (Bos sp.) diekstraksi dengan cara perendaman menggunakan NaOH 1N. pembuatan formula sabun transparan dalam beberapa konsentrasi yaitu 0,5%, 1%, 2,5%, dan 5% kolagen. Rendemen kolagen tulang sapi diperoleh 27,5%. Kolagen dalam sediaan dengan variasi konsentrasi menghasilkan warna dan kemampuan melembabkan kulit yang berbeda. Kolagen tulang sapi (Bos sp.) yang diformulasikan dalam sediaan sabun transparan dari kolagen tulang sapi (Bos sp.) dengan konsentrasi yaitu 0,5% termasuk kategori “lembab” dan sediaan sabun transparan dari kolagen tulang sapi (Bos sp.)  1%, 2,5%, dan 5% termasuk kategori “sangat lembab” dan hasil pengujian terhadap sukarelawan menunjukkan bahwa sabun transparan dari kolagen tulang sapi (Bos sp.) tidak menyebabkan iritasi. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-03-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/10 10.36490/journal-jps.com.v2i1.10 Journal of Pharmaceutical And Sciences; Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019); 1-9 2656-3088 10.36490/journal-jps.com.v2i1 ind https://www.journal-jps.com/index.php/jps/article/view/10/10 10.36490/journal-jps.com.v2i1.10.g10 Copyright (c) 2019 Nilsya Febrika Zebua, nilsya.zebua@gmail.com, Sudewi Sudewi, Sudewi, Masrina Prihatini, Masrina

oai:ojs2.journal-jps.com:article/11 2021-03-04T15:44:27Z jps:ART driver

ANALYSIS OF METAL CONTENTS LEAD AND CADMIUM IN URETIC ACID JAMU BY USING ATOMIC ABSORPTION SPECTROPHOTOMETRIC ANALISIS KANDUNGAN LOGAM TIMBAL DAN KADMIUM DALAM PRODUK JAMU ASAM URAT DENGAN MENGGUNAKAN SPEKTROFOTOMETRI SERAPAN ATOM Asra, Ridho Maisitoh, Maisitoh Rusdi, Rusdi Analysis of metal contents lead and cadmium in jamu asam urat using atomic absorption spectrophotometric has been done. The aim of this study is to analyze metal contents (lead and cadmium) in jamu asam urat with diffrent brands which are circulate in Padang cyti. Three samples of jamu asam urat with diffrent brands were analyzed the metal contents of lead and cadmium using atomic absorption spectrophotometric. The level of lead metal was obtained using regression equation y = 0.05378 + 0.02963x with R = 0.9977, and the level of cadmium metal was obtained using regression equation y = 0.08236 + 0.23186x with R = 0.9945. The result of this study showed that three samples were not detected containing  metal cadmium, but three samples were positive containing metal lead, 2.2055 ppm (samples I), 3.6465 ppm (samples II), and 3.0156 ppm (samples III). The renits showed that all samples qualified for healy metal contamination by BPOM that less than 10 ppm for Pb and less than 0.3 ppm for Cd heavy Analisis kandungan logam timbal dan kadmium dalam jamu asam urat menggunakan spektrofotometri serapan atom telah dilakukan. Tujuan dari penelitian ini adalah untuk menganalisis kandungan logam (timbal dan kadmium) dalam jamu asam urat dengan berbagai merek yang beredar di Kota Padang. Tiga sampel jamu asam urat dengan berbagai merek dianalisis kandungan logam timbal dan kadmium menggunakan spektrofotometri serapan atom. Tingkat logam timah diperoleh dengan menggunakan persamaan regresi y = 0,05378 + 0,02963x dengan R = 0,9977, dan tingkat logam kadmium diperoleh dengan menggunakan persamaan regresi y = 0,08236 + 0,23186x dengan R = 0,9945. Hasil penelitian ini menunjukkan bahwa tiga sampel tidak terdeteksi mengandung kadmium logam, tetapi tiga sampel positif mengandung timbal logam, 2,2055 ppm (sampel I), 3,6465 ppm (sampel II), dan 3,0156 ppm (sampel III). Hasil menunjukkan bahwa semua sampel memenuhi syarat untuk kontaminasi logam berat oleh BPOM yang kurang dari 10 ppm untuk Pb dan kurang dari 0,3 ppm untuk Cd. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-03-04 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/11 10.36490/journal-jps.com.v2i1.11 Journal of Pharmaceutical And Sciences; Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019); 10-16 2656-3088 10.36490/journal-jps.com.v2i1 ind https://www.journal-jps.com/index.php/jps/article/view/11/9 10.36490/journal-jps.com.v2i1.11.g9 Copyright (c) 2019 Ridho Asra, ridho, Maisitoh Maisitoh, Maisitoh, Rusdi Rusdi, Rusdi

oai:ojs2.journal-jps.com:article/12 2021-03-04T15:44:27Z jps:ART driver

The Use of Glucose Syrup as Product of Selulosa Hidrolyze from the Jackfruit Rags (Artocarpus heterophylus Lamk) as Sweetner on Candies Production from the Coconut Plam (Cocos Nucifera L) Pemanfaatan Sirup Glukosa Hasil Hidrolisa Selulosa dari Dami Nangka (Artocarpus heterophylus Lamk) sebagai Pemanis pada Pembuatan Manisan dari Buah Kelapa (Cocos Nucifera L) Sari, Nurmala Research on the influence of polysaccharides from the jackfruit rags (Artocarpus Heterophyllus Lamk) on the content of glucose syrups on hydrolyzing with HCl 30% has been done. A sample has got with simple random sampling. The cellulose was isolated from the seeds of rags. The cellulose was hydrolyzed by HCl 30% to produce glucose syrups. The content was analyzed by the Nelson-Somogyi method and calculated by regression analysis. The results of analysis show that the content of glucose syrups from the cellulose from the jackfruit rags were 2.47%.   Keywords: cellulose, jackfruit rags, glucose syrups, Hydrolysis Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-05-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/12 10.36490/journal-jps.com.v2i1.12 Journal of Pharmaceutical And Sciences; Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019); 17-23 2656-3088 10.36490/journal-jps.com.v2i1 ind https://www.journal-jps.com/index.php/jps/article/view/12/11 10.36490/journal-jps.com.v2i1.12.g11 Copyright (c) 2019 Nurmala Sari

oai:ojs2.journal-jps.com:article/13 2021-03-04T15:44:27Z jps:ART driver

Effects of Hypoglycemia on Patients with Type 2 Diabetes Mellitus on Therapy Adherence and Quality of Life Pengaruh Hipoglikemia pada Pasien Diabetes Melitus Tipe 2 terhadap Kepatuhan Terapi dan Kualitas Hidup Rusdi, Mesa Sukmadani Afriyeni, Helmice Diabetes mellitus (DM) is a metabolic disorder characterized by an increase in blood sugar due to a decreasing in insulin secretion by pancreatic beta cells and/or impaired insulin function (insulin resistance). Based on the International Diabetes Federation (IDF) (2015), Indonesia was ranked 7th in the world with 10 million people suffered from DM. DM can become serious and cause a chronic condition that is dangerous if not treated and not adhered in taking medication. The main risks associated with DM are hypoglycemia, hyperglycemia, diabetic ketoacidosis, dehydration, and thrombosis. The incidence of hypoglycemia can be influenced by age factors, duration of suffering from diabetes, weight, and glycemic control. Acute and chronic complications of hypoglycemia can interfere with life, such as social interaction, sleep, sexual activity, driving, sports, and other activities. The purpose of this study was to determine the effect of hypoglycemia in type 2 DM patients on therapy adherence and quality of life. The design of this study was a cross-sectional study with subjects of the research were adult patients with type 2 DM who used oral anti-diabetes medication for more than 6 months. Patients who have a history of hypoglycemia are divided into 3 groups, namely (1) Having hypoglycemia in the last 3 months; (2) Not experiencing hypoglycemia in the last 3 months; (3) Never experience hypoglycemia. Measurement of adherence using the Morisky Modified Adherence Scale (MMAS), measurement of quality of life with Diabetes Quality of Life Questionnaire (DQoL), data obtained will be processed statistically using Chi-Square Test. The result of this study was unable to prove the relationship of hypoglycemia to therapy adherence (p = 0.756; p> 0.05) and the quality of life of patients (p = 0.143; p> 0.05). Diabetes melitus  (DM) adalah penyakit gangguan metabolik yang ditandai oleh kenaikan gula darah akibat penurunan sekresi insulin oleh sel beta pankreas dan atau ganguan fungsi insulin (resistensi insulin). Berdasarkan International Diabetes Federation (IDF) (2015), Indonesia berada pada peringkat ke-7 dunia dengan prevalensi DM sebanyak 10 juta jiwa. DM dapat menjadi serius dan menyebabkan kondisi kronik yang membahayakan apabila tidak diobati dan tidak patuh dalam minum obat. Risiko utama terkait penyakit DM adalah hipoglikemia, hiperglikemia, ketoasidosis diabetik, dehidrasi dan trombosis. Kejadian hipoglikemia dapat dipengaruhi oleh faktor umur, durasi menderita DM, berat badan, dan kontrol glikemik. Komplikasi akut dan kronis dari hipoglikemia dapat mengganggu kehidupan, seperti interaksi sosial, tidur, aktivitas seks, mengemudi, olahraga, dan aktivitas lainnya. Tujuan penelitian ini adalah untuk mengetahui pengaruh hipoglikemia pada pasien DM tipe 2 terhadap kepatuhan terapi dan kualitas hidup. Desain penelitian ini adalah cross sectional study atau studi potong lintang dengan subjek penelitian pasien DM Tipe 2 dewasa yang menggunakan obat Anti Diabetes Oral (ADO) lebih dari 6 bulan. Pasien yang memiliki riwayat hipoglikemia dibagi menjadi 3 grup, yaitu (1) Mengalami hipoglikemi 3 bulan terakhir; (2) Tidak mengalami hipoglikemi dalam 3 bulan terakhir; (3) Tidak pernah mengalami kejadian hipoglikemia. Pengukuran kepatuhan menggunakan Morisky Modified Adherence Scale(MMAS), pengukuran kualitas hidup dengan Diabetes Quality of Life Questionnaire (DQoL), data yang diperoleh akan diolah secara statistik dengan menggunakan Uji Chi Square. Pada penelitian ini belum bisa membuktikan hubungan hipoglikemia terhadap kepatuhan terapi (p = 0,756; p>0,05) dan kualitas hidup pasien (p=0.143; p> 0,05). Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/13 10.36490/journal-jps.com.v2i1.13 Journal of Pharmaceutical And Sciences; Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019); 24-29 2656-3088 10.36490/journal-jps.com.v2i1 ind https://www.journal-jps.com/index.php/jps/article/view/13/12 10.36490/journal-jps.com.v2i1.13.g12 Copyright (c) 2019 Mesa Sukmadani Rusdi

oai:ojs2.journal-jps.com:article/17 2021-03-04T15:43:51Z jps:ART driver

Antioxidant Activities from Ethanol Extract, Hexane, Ethyl Acetate, and Water Fractions of Kapulaga Leaf (Elettaria cardamomum (L.) Maton) Uji Aktivitas Antioksidan Ekstrak Etanol Fraksi Heksan, Fraksi Etil Asetat dan Fraksi Air Daun Kapulaga (Elettaria cardamomum (L.) Maton) ASRA, RIDHO Azni, Nize Ria Rusdi, Rusdi Nessa, Nessa This study aims to determine the antioxidant activity of the ethanol extract, hexane fraction, ethyl acetate fraction and water fraction of cardamom leaves (Elettaria cardamomum (L.) Maton). Dried of cardamom leaves was extracted by maceration using 70 % ethanol, then followed by fractionation based on the level of polarity with hexane, ethyl acetate, and water solvents. Antioxidant activity examination was determined using reagent DPPH using UV-Visible spectrophotometry and gallic acid as standard. The results of phytochemical screening showed that ethanol extract and water fraction of cardamom leaves contains phenol, flavonoids, tannins, and saponins, for ethyl acetate fraction contains phenol, flavonoids, and tannins, for hexane fraction the results were negative for all the compounds tested. The results of the antioxidant activity examination of ethanolic extract, hexane fraction, ethyl acetate fraction and water fraction of cardamom leaves showed the IC50 of 4058.7 μg/mL, 8419.3 μg/mL, 2281.7 μg/mL, and 3889.6 μg/mL respectively, whereas gallic acid showed the IC50 value of 4.89 μg/mL. Based on IC50 values ethanol extract, hexane fraction, ethyl acetate fraction and water fraction of cardamom leaves have weak antioxidant activity compared to gallic acid which has high antioxidant activity. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan ekstrak etanol, fraksi heksan, fraksi etil asetat dan fraksi air daun kapulaga (Elettaria cardamomum (L.) Maton). Simplisia daun kapulaga diekstraksi dengan cara maserasi dengan menggunakan pelarut etanol 70 %, kemudian dilanjutkan dengan fraksinasi berdasarkan tingkat kepolaran dengan pelarut heksan, etil asetat dan air. Pengujian aktivitas antioksidan dilakukan dengan metode DPPH menggunakan spektrofotometri UV-Vis dan asam galat sebagai pembanding. Hasil uji fitokimia menunjukkan bahwa ekstrak etanol dan fraksi air daun kapulaga mengandung senyawa fenol, flavonoid, tanin dan saponin, untuk fraksi etil asetat mengandung fenol, flavonoid dan tanin, untuk fraksi heksan didapatkan hasil yang negatif pada semua senyawa yang diuji. Hasil pengujian aktivitas antioksidan ekstrak etanol, fraksi heksan, fraksi etil asetat dan fraksi air daun kapulaga dengan IC50 berturut-turut 4058,7 μg/mL, 8419,3 μg/mL, 2281,7 μg/mL and 3889,6 μg/mL, sedangkan IC50 asam galat 4,89 μg/mL. Berdasarkan nilai IC50 ekstrak etanol, fraksi heksan, fraksi etil asetat dan fraksi air dari daun kapulaga memiliki aktivitas antioksidan yang lemah jika dibandingkan dengan asam galat yang memiliki aktivitas antioksidan yang kuat Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/17 10.36490/journal-jps.com.v2i1.17 Journal of Pharmaceutical And Sciences; Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019); 30-37 2656-3088 10.36490/journal-jps.com.v2i1 ind https://www.journal-jps.com/index.php/jps/article/view/17/13 10.36490/journal-jps.com.v2i1.17.g13 Copyright (c) 2019 RIDHO ASRA

oai:ojs2.journal-jps.com:article/18 2021-03-04T15:43:51Z jps:ART driver

Screening of Antibacterial Activity of Extract And Fraction of Flower Petals Mussaenda Frondosa L Skrining Aktivitas Antibakteri Fraksi Kelopak Bunga Mussaenda frondosa L. Efendi, M. Rifqi Background: Antibiotics are the most effective drugs against microbial infections, but slowly lose their efficacy to microorganisms due to resistance. So, nowadays, research related to finding new compounds from nature to treat infectious diseases has become important. Mussaenda frondosa L. is a tropical plant native to Indonesia. Traditionally, Mussaenda frondosa L. has been used for the treatment of various diseases, such as headaches and jaundice. The literature study of the antibacterial activity of Mussaenda frondosa L. is still very limited, so research needs to be done regarding the antibacterial activity. Objective: to determine whether there is antibacterial activity from Mussaenda frondosa L. petal fraction. And whether there is significant antibacterial activity when it is compared to chloramphenicol as positive control antibiotic. Method: The methodology of this research starts with sampling, sample identification, extraction, and fractionation. Screening for antibacterial activity was carried out by the agar diffusion method. Results: The most potential antibacterial activity was ethyl acetate fraction with an inhibitory diameter of 5.6 - 8.3 mm against 12 test pathogenic bacteria, except Streptococcus mutans ATCC 25175. The n-hexane fraction showed antibacterial activity against Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853 and Vibrio cholerae inaba with an inhibitory diameter of 6.0 - 7.5 mm. Meanwhile, the n-butanol fraction has only antibacterial activity against Staphylococcus aureus ATCC 25923 with a 7.5 mm inhibition diameter. Conclusion: the most potential fraction that had antibacterial activity was ethyl acetate fraction, by inhibiting 12 test pathogenic bacterias, followed by n-hexane fraction which inhibits 3 bacterias. Latar belakang: Antibiotik adalah obat yang paling efektif melawan infeksi mikroba namun, perlahan kehilangan efikasinya terhadap mikroorganisme dikarenakan resistensi. Sehingga, pada beberapa tahun terakhir ini, penelitian terkait pencarian senyawa baru dari alam untuk penanganan penyakit infeksi menjadi penting untuk dilakukan. Bunga Nusa Indah (Mussaenda frondosa L.) merupakan tumbuhan tropis asli Indonesia. Secara tradisional, Mussaenda frondosa L. telah digunakan untuk pengobatan berbagai penyakit, seperti sakit kepala dan jaundice. Studi literatur terhadap aktivitas antibakteri bunga nusa indah masih sangat terbatas, sehingga perlu dilakukan penelitian terkait aktivitas antibakteri Tujuan: untuk mengetahui apakah terdapat aktivitas antibakteri dari fraksi kelopak bunga Mussaenda frondosa L. dan apakah signifikan aktivitas antibakteri fraksi kelopak bunga Mussaenda frondosa L dibandingkan dengan pembanding kloramfenikol. Metode: Metodologi penelitian ini dimulai dari pengambilan sampel, identifikasi sampel, ekstraksi dan fraksinasi. Skrining pengujian aktivitas antibakteri dilakukan dengan metode difusi agar Hasil: Aktivitas antibakteri paling potensial adalah fraksi etil asetat dengan diameter hambat 5,6 – 8,3 mm terhadap 12 bakteri patogen uji, kecuali Streptococcus mutans ATCC 25175. Fraksi n-heksana menunjukkan aktivitas antibakteri terhadap Staphylococcus aureus ATCC 25923, Pseudomonas aeruginosa ATCC 27853 dan Vibrio cholerae inaba dengan diameter hambat 6,0 – 7,5 mm. Sedangkan, fraksi butanol hanya memiliki aktivitas antibakteri terhadap Staphylococcus aureus ATCC 25923 dengan diameter hambat 7,5 mm. Kesimpulan: fraksi yang paling potensial dalam menghambat bakteri uji adalah fraksi etil asetat, dengan menghambat 12 bakteri patogen uji, diikuti oleh fraksi n-heksana yang menghambat 3 bakteri. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-07-22 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/18 10.36490/journal-jps.com.v2i1.18 Journal of Pharmaceutical And Sciences; Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019); 38-44 2656-3088 10.36490/journal-jps.com.v2i1 ind https://www.journal-jps.com/index.php/jps/article/view/18/14 10.36490/journal-jps.com.v2i1.18.g14 Copyright (c) 2019 M. Rifqi Efendi

oai:ojs2.journal-jps.com:article/19 2021-03-04T15:43:51Z jps:ART driver

Formulation and Physical Stability Test Ointment from Leaf Extract of Bitter Melon (Momordica charantia L) as Wound Medicine Formulasi dan Uji Stabilitas Fisik Sediaan Salep Dari Ekstrak Etanol Daun Pare (Momordica Charantia L) Sebagai Obat Luka Fauziah, Fauziah Widiyanti, Siti Arum Rinaldi, Rinaldi Silviana, Ernita Bitter melon leaves contain secondary metabolites such as flavonoids, tannins, saponins, steroids, alkaloids, and terpenoids which can inhibit bacterial growth. Bitter melon leaves can be used as a medicine, one of which is to treat wounds because they have bacterial inhibition and can cover wounds. This study aims to determine the effect of the basis on the stability of ointment and to find out which formulations meet the stability requirements of ointment. This type of research is experimental. The base of the ointment used is the base of the hydrocarbon ointment and the base of the absorbent ointment. The extract of pare leaf extract was carried out by maceration using 70% ethanol. The pare ethanol extract ointment was made in 3 formulas using the same base and different concentrations of the extract. Preparation of ointments using the smelting method. Evaluation of ointment was carried out by organoleptic test, homogeneity test, pH measurement test, and dispersion test. The test results of all ointment preparations from the formula I, formula II and formula III met the organoleptic test quality parameters, homogeneity and pH test. For the spread test on each formula, the only formula I approach the physical stability test parameter.   Daun pare mengandung senyawa metabolit sekunder seperti flavonoid, tanin, saponin, steroid, alkaloid, dan terpenoid yang dapat menghambat pertumbuhan bakteri. Daun pare dapat dimanfaatkan sebagai obat, salah satunya yaitu untuk mengobati luka karena mempunyai daya hambat bakteri dan dapat menutup luka. Penelitian ini bertujuan untuk mengetahui pengaruh basis terhadap stabilitas salep dan untuk mengetahui formulasi mana yang memenuhi syarat stabilitas sediaan salep. Jenis penelitian ini ialah eksperimental. Dasar salep yang digunakan yaitu dasar salep hidrokarbon dan dasar salep serap. Penyarian ekstrak daun pare dilakukan dengan cara maserasi menggunakan pelarut etanol 70%. Salep ekstrak etanol daun pare dibuat sebanyak 3 formula dengan menggunakan basis yang sama dan konsentrasi ekstrak yang bebeda. Pembuatan sediaan salep menggunakan metode peleburan. Evaluasi sediaan salep dilakukan dengan uji organoleptik, uji homogenitas, uji pengukuran pH dan uji daya sebar. Hasil pengujian semua sediaan salep dari formula I, formula II dan formula III memenuhi parameter kualitas uji organoleptis, homogenitas dan uji pH. Untuk pengujian daya sebar pada masing-masing formula hanya formula I yang mendekati parameter uji stabilitas fisik. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-07-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/19 10.36490/journal-jps.com.v2i1.19 Journal of Pharmaceutical And Sciences; Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019); 45-51 2656-3088 10.36490/journal-jps.com.v2i1 ind https://www.journal-jps.com/index.php/jps/article/view/19/15 10.36490/journal-jps.com.v2i1.19.g15 Copyright (c) 2019 Fauziah Fauziah, Siti Arum Widiyanti, Rinaldi Rinaldi, Ernita Silviana

oai:ojs2.journal-jps.com:article/20 2021-03-04T15:43:51Z jps:ART driver

PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITIES OF KEMANGI LEAF (Ocimum tenuiflorum L.) METHANOL EXTRACT USING DPPH (1,1-diphenyl-2-pikrilhidrazil) METHOD SKRINING FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL DAUN KEMANGI (Ocimum tenuiflorum L.) DENGAN METODE DPPH (1,1-difenil-2-pikrilhidrazil) Chandra, Boy Sari, Rezza Puspita Misfadhila, Sestry Azizah, Zikra Asra, Ridho Research on phytochemical tests and antioxidant activity of methanol extract of basil leaves (Ocimum tenuiflorum L.) was carried out. Simplicia of basil leaves macerated with   98 % methanol obtained an extract of 45.5479 g with a yield of 22.77 %. Methanol extract of basil leaves contains alkaloid, flavonoid, phenol, tannin, saponin, and steroid. The extract is known to have antioxidant activity by decreasing DPPH absorptions. The antioxidant activity of methanol extract of basil leaves was carried out using the DPPH method for determination of IC50.Values from the test it can be seen that basil leaf extract has antioxidant activity with an IC50 value of 13.7092 ppm. Based on IC50 values showed that the methanol extract of basil leaves has very weak antioxidant activity. Penelitian tentang uji fitokimia dan aktivitas antioksidan ekstrak metanol daun kemangi (Ocimum tenuiflorum L.) telah dilakukan. Simplisia daun kemangi dimaserasi dengan metanol 98 % diperoleh ekstrak sebesar 45,5479 g dengan rendemen 22,77 %. Ekstrak metanol daun kemangi megandung senyawa alkaloid, flavanoid, fenol, tanin, saponin, dan steroid. Ekstrak diketahui memiliki aktivitas antioksidan dengan menurunnya absorban DPPH. Aktivitas antioksidan dari ekstrak metanol daun kemangi dilakukan menggunakan metode DPPH untuk penentuan IC50. Dari pengujian dapat diketahui bahwa ekstrak daun kemangi memiliki aktivitas antioksidan dengan nilai IC50 1370,92 ppm. Berdasarkan nilai IC50 menunjukkan bahwa ekstrak metanol daun kemangi memiliki aktivitas antioksidan yang sangat lemah   Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-08-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/20 10.36490/journal-jps.com.v2i2.20 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 1-8 2656-3088 10.36490/journal-jps.com.v2i2 ind https://www.journal-jps.com/index.php/jps/article/view/20/16 10.36490/journal-jps.com.v2i2.20.g16 Copyright (c) 2019 Ridho Asra

oai:ojs2.journal-jps.com:article/21 2021-03-04T15:43:51Z jps:ART driver

APHRODISIAC EFFECTIVENESS TEST ETHANOL EXTRACT ALBEDO (MESOCARP) MELON (Cucumis melo L.) ON Mice (Mus musculus) Gunawan, Muhammad Gun Bengi, Nolani Nurlita Decreased sexual desire is one of the factors of disharmony in the marital relationship and quite disturbing in domestic life, Medicine is traditionally widely taken, one using plants containing aphrodisiac. Aphrodisiac a kind of aphrodisiac to increase sex drive.In general, the plant compound that has potential as aphrodisiac is citrulline. Melon (Cucumis melo L.) is a plant that contains citrulline, which is used in the coating of white / albedo (mesocarp).This study aims to determine the melon fruit mesocarp have afrodisiaka effect on the effective dose. This study is an experimental method is percolation extraction using 30 mice were divided into 5 groups. Group I (CMC 0.5%), group II (herbal pegs the earth), Group III, IV, and V respectively using albedo Ethanol Extract Melon (EEAM) doses of 9, 18 and 36 g / kg. Oral administration by introducing watching, climbing and coitus. Observations were made for 5 days in a row. Statistical testing using test methods Post-Hoc Duncan SPSS 24.0. Statistical analysis showed no significant differences between the test group with α> 0.05 and an effective dose of 18g / kg. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-09-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/21 10.36490/journal-jps.com.v2i2.21 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 9-17 2656-3088 10.36490/journal-jps.com.v2i2 ind https://www.journal-jps.com/index.php/jps/article/view/21/17 10.36490/journal-jps.com.v2i2.21.g17 Copyright (c) 2019 Muhammad Gun Gunawan

oai:ojs2.journal-jps.com:article/22 2021-03-04T15:43:51Z jps:ART driver

DETERMINATION OF POTASSIUM, CALCIUM, AND SODIUM LEVEL IN FRESH AND BOILED CHIVES (Allium schoenoprasum L.) LEAVES BY ATOMIC ABSORPTION SPECTROPHOTOMETRY PENETAPAN KADAR KALIUM, KALSIUM, DAN NATRIUM PADA DAUN KUCAI (Allium schoenoprasum L.) SEGAR DAN DIREBUS SECARA SPEKTROFOTOMETRI SERAPAN ATOM Iksen, Iksen Haro, Ginda Masfria, Masfria Chives (Allium schoenoprasum L.) is a long-lived plant that is very easy to grow. This plant is known as the vegetable of the Liliaceae family. Traditionally, chives are used as anti-hypertension and anti lithogenesis drugs. This study aims to determine the differences and compare the amount of potassium, calcium, and sodium in fresh and boiled chives. The method chosen in this study was atomic absorption spectrophotometry and performed at a wavelength of 766.5 nm, 422.7 nm, dan 589.0 nm. The results showed the level of potassium in chives is (321.1147± 0.9891) mg/100 g and the boiled chives for (169.2157± 1.9352) mg/100 g. Levels of calcium in fresh chives (47.4054± 0.7960) mg/100 g and boiled chives for (43.8424± 0.1995) mg/100 g. Levels of sodium in fresh chives (10.0729± 0.0619) mg/100 g and boiled chives for (4.2025± 0.0564) mg/100 g. The Chives decreasing percentage after boiled for potassium is 47.30%, 7.52 % for calcium, and 58.28% for sodium. Statistically different test average content of potassium, calcium, and sodium between fresh chives and boiled using the F distribution, concluded that the content of potassium, calcium, and sodium in fresh chive significantly higher than boiled chives. Kucai (Allium schoenoprasum, L.) adalah tanaman yang berumur panjang (perrenial) yang sangat mudah tumbuh. Tanaman ini dikenal sebagai sayuran dari keluarga Liliaceae. Secara tradisional, kucai digunakan sebagai obat anti hipertensi dan peluruh batu ginjal. Tujuan penelitian ini adalah untuk untuk mengetahui perbedaan kandungan kalium, kalsium, dan natrium pada kucai yang segar dan direbus. Metode yang dipilih dalam penelitian ini adalah secara spektrofotometri serapan atom yang dilakukan pada panjang gelombang 766,5 nm , 422,7 nm, dan 589,0 nm. Hasil penelitian ini menunjukkan kadar kalium pada daun kucai segar sebesar (321,1147±0,9891) mg/100 g dan pada daun kucai rebus sebesar (169,2157±1,9352) mg/100 g. Kadar kalsium pada daun kucai segar sebesar (47,4054±0,7960) mg/100 g dan pada daun kucai rebus sebesar (43,8424±0,1995) mg/100 g. Kadar natrium pada daun kucai segar sebesar (10,0729±0,0619) mg/100 g sedangkan pada daun kucai rebus sebesar (4,2025±0,0564) mg/100 g. Sedangkan persentase penurunan kadar mineral setelah direbus untuk kalium adalah 47,30%, untuk kalsium sebesar 7,52%, dan untuk natrium sebesar 58,28 %.Secara statistik uji beda rata-rata kandungan kalium, kalsium, dan natrium antara daun kucai segar dan rebus dengan menggunakan distribusi F, menyimpulkan bahwa kandungan kalium, kalsium, dan natrium pada daun kucai segar lebih tinggi secara signifikan dari daun kucai rebus. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-11-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/22 10.36490/journal-jps.com.v2i2.22 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 24-28 2656-3088 10.36490/journal-jps.com.v2i2 ind https://www.journal-jps.com/index.php/jps/article/view/22/20 10.36490/journal-jps.com.v2i2.22.g20 Copyright (c) 2019 Iksen Iksen, Ginda Haro, Masfria Masfria http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/23 2021-03-04T15:43:51Z jps:ART driver

IDENTIFICATION OF ESCHERICHIA COLI IN GRASS JELLY SOLD AT PASAR BARU STABAT IDENTIFIKASI ES CHERICHIA COLI PADA CINCAU YANG DIJUAL DI PASAR BARU STABAT Sapitri, Alfi Afrinasari, Intan Escherichia coli found in human and animal intestine. These bacteria easily spread by contaminated water and food. It can happen on grass jelly (Mesona palustris), which has a high carbohydrate, fiber, and nutrients. Some people use a mixture of grass jelly drinks as well as traditional medicine. This research intended to identify bacterial contamination E. coli of grass jelly sold at Pasar Baru Stabat. The samples in this study are the grass jelly derived from 5 merchants. This research is a descriptive study. The research method was MPN (Most Probable Number) for calculating the coliform bacteria, followed by examination of Lactose Broth media, Brilliant Green Lactose Broth media, Eosin Methylene Blue Agar media, gram stains, and biochemistry test. The results of this study indicated five samples tested, and there is one positive sample contaminated with bacteria E. Coli a four negative samples contaminated with E. coli. So that four samples were suitable for consumption, and one sample was not suitable for consumption. Escherichia coli ditemukan di usus manusia dan hewan. Bakteri ini mudah menyebar dengan mencemari air dan makanan. itu bisa terjadi pada cincau (Mesona palustris) yang memiliki karbohidrat, serat dan nutrisi yang tinggi. Sebagian orang menggunakan campuran minuman cincau dan juga obat tradisional. Penelitian ini bertujuan untuk mengidentifikasi kontaminasi bakteri E. coli cincau yang dijual di Pasar Baru Stabat. Sampel dalam penelitian ini adalah cincau yang berasal dari 5 pedagang. Penelitian ini merupakan penelitian deskriptif. Metode penelitian adalah MPN (Most Probable Number) untuk menghitung bakteri coliform, diikuti dengan pemeriksaan media Lactosa Broth, Brilliant Green Lactose Broth media, media Eosin Metilyene Blue Agar, pewarnaan gram dan tes Biokimia. Hasil penelitian ini menunjukkan lima sampel yang diuji, ada satu sampel positif yang terkontaminasi dengan bakteri E. Coli dan 4 sampel negatif yang terkontaminasi E. coli. Sehingga empat sampel cocok untuk dikonsumsi dan satu sampel tidak sesuai untuk konsumsi. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-11-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/23 10.36490/journal-jps.com.v2i2.23 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 18-23 2656-3088 10.36490/journal-jps.com.v2i2 ind https://www.journal-jps.com/index.php/jps/article/view/23/19 10.36490/journal-jps.com.v2i2.23.g19 Copyright (c) 2019 Alfi Sapitri http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/25 2021-03-04T15:43:51Z jps:ART driver

STUDY OF COMMUNITY KNOWLEDGE OF ANTIBIOTIC USE IN PUSKESMAS RASIMAH AHMAD BUKITTINGGI STUDI TINGKAT PENGETAHUAN MASYARAKAT TERHADAP PENGGUNAAN ANTIBIOTIK DI PUSKESMAS RASIMAH AHMAD BUKITTINGGI Yulia, Rahma Putri, Rika Wahyudi, Rino A Study of Community Knowledge Levels on the Use of Antibiotics has conducted at Puskesmas Rasimah Ahmad Bukittinggi. Less knowledge regarding the use of antibiotics can cause inaccuracy in the use of antibiotics themselves. This inaccuracy can cause health problems in the form of resistance. This study aims to determine the level of public knowledge about the use of antibiotics. Research data collection carried out using a questionnaire with a descriptive method for selecting respondents using accidental sampling techniques from one hundred respondents who met the inclusion and exclusion criteria. Data were analyzed using a computer program. Based on the results of research data, the level of knowledge shows that 17 people (17%) of respondents have less knowledgeable and 60 people (60%) of respondents have enough knowledge, and as many as 23 people (23%) have good knowledge. From these results, it can conclude that overall the level of public knowledge about the use of antibiotics is in the sufficient category. Thus increasing knowledge of the use of antibiotics needs to be further improved, one of which is to increase the role of health workers, especially pharmacists, to give information to the public through communication, information, and education (IEC) on the use of antibiotics. Telah dilakukan Studi Tingkat Pengetahuan Masyarakat Terhadap Penggunaan Antibiotik Di  Puskesmas  Rasimah Ahmad Bukittinggi. Kurangnya pengetahuan terkait penggunaan antibiotik dapat menyebabkan ketidaktepatan akan penggunaan antibiotik itu sendiri. Ketidaktepatan ini dapat menimbulkan permasalahan kesehatan berupa resistensi. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan masyarakat terhadap penggunaan antibiotik. Alat pengumpul data menggunakan kuesioner dengan metode deskriptif dan cara pengambilan responden dengan teknik Accidental Sampling dengan jumlah responden sebanyak 100 orang dengan kriteria inklusi dan eksklusi tertentu. Data dianalisi dengan menggunakan program komputer. Berdasarkan hasil data penelitian tingkat pengetahuan menunjukkan bahwa 17 orang (17%) responden memiliki pengetahuan yang kurang, 60 orang (60%) responden memiliki pengetahuan cukup dan sebanyak 23 orang (23%) memiliki pengetahuan baik. Dari hasil tersebut dapat disimpulkan bahwa secara keseluruhan tingkat pengetahuan masyarakat terhadap penggunaan antibiotik berada dalam kategori cukup. Dengan demikian peningkatan pengetahuan terhadap penggunaan antibiotik perlu lebih ditingkatkan, salah satunya adalah meningkatkan peran petugas kesehatan terutama apoteker untuk memberikan sosialisasi kepada masyarakat dengan cara komunikasi, memberikan informasi dan edukasi (KIE) terhadap penggunaan antibiotik.   Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-01-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/25 10.36490/journal-jps.com.v2i2.25 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 43-48 2656-3088 10.36490/journal-jps.com.v2i2 ind https://www.journal-jps.com/index.php/jps/article/view/25/23 10.36490/journal-jps.com.v2i2.25.g23 Copyright (c) 2020 Rahma Yulia, Rika Putri, Rino Wahyudi http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/26 2021-03-04T15:44:27Z jps:ART driver

KNOWLEDGE DESCRIPTION OF STUDENT FACULTY PHARMACY TJUT NYAK DHIEN UNIVERSITY MEDAN ABOUT ANTIBIOTIC USE GAMBARAN PENGETAHUAN MAHASISWA FAKULTAS FARMASI UNIVERSITAS TJUT NYAK DHIEN MEDAN TERHADAP PENGGUNAAN ANTIBIOTIK Hasanah, Fenny Siahaan, Desy Natalia Antibiotic abuse by using it alone without consulting a doctor on students continues to be a significant problem in developed and developing countries. This is because many cases of antibiotics are used irrationally so that they are directly related to the possibility of resistance. The purpose of this study was to determine the level of knowledge of Tjut Nyak Dhien University Pharmacy Faculty students in Medan on the use of antibiotics. This study used a descriptive analytical approach using a questionnaire. The results showed that of 232 students 52% of students had high knowledge, 38% of students had moderate knowledge and 10% of students had low knowledge. Penyalahgunaan antibiotik dengan cara penggunaan secara sendiri tanpa konsultasi kepada dokter pada mahasiswa terus menjadi masalah yang signifikan di negara maju dan negara berkembang. Hal tersebut disebabkan karena banyak kasus antibiotik digunakan secara tidak rasional sehingga berhubungan langsung dengan kemungkinan terjadinya resistensi. Tujuan dari penelitian ini adalah untuk mengetahui tingkat pengetahuan mahasiswa Fakultas Farmasi Universitas Tjut Nyak Dhien Medan terhadap penggunaan antibiotik. Penelitian ini menggunakan pendekatan deskriptif analitik dengan menggunakan kuesioner. Hasil penelitian menunjukkan dari 232  mahasiswa sebanyak 52% mahasiswa memiliki pengetahuan yang tinggi, 38% mahasiswa memiliki pengetahuan sedang dan 10% mahasiswa memiliki pengetahuan rendah. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-06-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/26 10.36490/journal-jps.com.v2i1.26 Journal of Pharmaceutical And Sciences; Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019); 52-56 2656-3088 10.36490/journal-jps.com.v2i1 ind https://www.journal-jps.com/index.php/jps/article/view/26/18 10.36490/journal-jps.com.v2i1.26.g18 Copyright (c) 2019 Fenny Hasanah, Desy Natalia Siahaan http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/27 2021-03-04T15:43:51Z jps:ART driver

THE EFFECT OF STORAGE TEMPERATURE ON PHOSPATE CLINDAMYCIN STABILITY IN EMULGEL DOSAGE FORM WITH HIDROXYPROPYL METHYL CELLULOSE (HPMC) AS A GELLING AGENT PENGARUH SUHU PENYIMPANAN TERHADAP STABILITAS KLINDAMISIN FOSFAT DALAM SEDIAAN EMULGEL DENGAN HYDROXYPROPYL METHYLCELLULOSE (HPMC) SEBAGAI GELLING AGENT Wahyuni, Yenni Sri Erjon, Erjon Aftarida, Reza The present study was undertaken to investigate the effect of temperature on the degradation of clindamycin phosphate emulgel. This study aims to determine the rate of decomposition of clindamycin phosphate emulgel was storage at three different temperature of 30˚C, 50˚C, and 70˚C. Determination of percentage clindamycin phosphate was carried out every hour for 5 hours using Spectrophotometry UV-VIS. The results were statistically analyzed using the paired t-test. It was found a decrease in the levels of clindamycin phosphate emulgel at the storage temperature of 30˚C by 99.0874;  50˚C by 96.9314%, and a storage temperature of 70˚C by 96.0114%. Therefore, it can be said that clindamycin phosphate in emulgel preparations is chemically stable for 5 hours at a storage temperature of 30˚C, 50˚C, and 70˚C and the kinetics of the degradation rate of clindamycin phosphate in the emulgel preparation is in accordance with the second-order. Based on the statistically processed data result, it can be concluded that the storage temperature of 30˚C, 50˚C, and 70˚C shows that there is a significant difference (<0.005) in the data. Telah dilakukan penelitian tentang pengaruh suhu penyimpanan terhadap stabilitas klindamisin fosfat dalam sediaan emulgel. Penelitian ini bertujuan untuk mengetahui laju penguraian klindamisin fosfat dikarenakan variasi suhu penyimpanan dalam sediaan emulgel Emulgel klindamisin fosfat dilakukan penyimpanan pada suhu 30˚C, 50˚C, dan 70˚C. Pengukuran kadar dilakukan pada tiap interval waktu pada jam ke-0; 1; 2; 3; 4, dan jam ke-5. Penetapan kadar emulgel klindamisin fosfat menggunakan spektrofotometri UV-Vis kemudian hasil perolehan data dianalisa secara statistik menggunakan uji t berpasangan. Dari hasil penelitian didapatkan adanya penurunan kadar emulgel klindamisin fosfat pada sediaan dengan suhu penyimpanan 30˚C sebesar 99,0874%, suhu penyimpanan 50˚C sebesar 96,9314%, dan suhu penyimpanan 70˚C sebesar 96,0114% sehingga dapat dikatakan bahwa klindamisin fosfat dalam sediaan emulgel stabil secara kimia selama 5 jam pada suhu penyimpanan 30˚C, 50˚C, dan 70˚C dan kinetika laju penguraian klindamisin fosfat dalam sediaan emulgel mengikuti orde-2. Berdasarkan hasil pengolahan data secara statistik dapat dinyatakan bahwa suhu penyimpanan 30˚C, 50˚C, dan 70˚C menunjukkan data ada perbedaan signifikan (< 0.005) Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-12-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/27 10.36490/journal-jps.com.v2i2.27 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 36-42 2656-3088 10.36490/journal-jps.com.v2i2 ind https://www.journal-jps.com/index.php/jps/article/view/27/22 10.36490/journal-jps.com.v2i2.27.g22 Copyright (c) 2019 Yenni Sri Wahyuni, Erjon Erjon, Reza Aftarida http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/28 2021-03-04T15:43:50Z jps:ART driver

ANTIBACTERIAL ACTIVITY TEST OF EXTRACT ETHANOL OF JACKFRUIT LEAVES (Artocarpus heterophyllus. Lamk.) OF BACTERIA Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis and Salmonella typhi UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lamk.) TERHADAP BAKTERI Staphylococcus aureus, Escherichia coli, Staphylococcus epidermis, DAN Salmonella typhi Gurning, Kasta Siahaan, Dameria Iksen, Iksen Jackfruit leaves (Artocarpus heterophyllus Lamk.) have health benefits as an antimicrobial. The leaves contain flavonoids, tannins, saponins which act as antimicrobials. The purpose of this study was to study the potential antibacterial activity of ethanol extract of jackfruit leaves (Artocarpus heterophyllus Lamk.) On the bacteria Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and Salmonella typhi. This research conducted with an experimental method that included the collection and processing of samples, the examination of the simplicia characterization and phytochemical screening. The concentration of jackfruit leaf ethanol extract. Used was at a concentration of 500 mg mL, 400 mg/mL, 300 mg/mL, 200 mg/mL, 100 mg/mL, 100 mg/mL, 50 mg/mL , 25 mg/mL, 10 mg/mL 30 mg/ml chloramphenicol and blanks. Using the disk diffusion method to measure the clear zone against the bacteria Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, and Salmonella typhi. Antimicrobial inhibition of ethanol extract of jackfruit leaves against Staphylococcus aureus bacteria at a concentration of 500 mg/mL has a strong antibacterial inhibition with a diameter of 10.8 mm. The bacteria Escherichia coli, Staphylococcus epidermidis, and Salmonella typhi at a concentration of 500 mg/mL have inhibitory power, 9.2 mm, 9.6 mm, and 8.8 mm in the medium category. Positive control chloramphenicol has powerful antibacterial inhibition with an inhibition zone diameter of 28.6 mm. Daun nangka (Artocarpus heterophyllus Lamk.) mempunyai manfaat bagi kesehatan sebagai anti mikroba. Daun nangka mengandung flavonoid, tanin, saponin yang bersifat sebagai antimikroba. Tujuan penelitian ini untuk mengetahui potensi aktivitas antibakteri ekstrak etanol daun nangka (Artocarpus heterophyllus Lamk.) terhadap bakteri Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, dan Salmonella typhi. Penelitian ini dilakukan dengan metode eksperimental meliputi pengumpulan dan pengolahan sampel, pemeriksaan karakterisasi simplisia dan skrining fitokimia. Konsentrasi Ekstrak etanol daun nangka (Artocarpus heterophyllus Lamk.) yang digunakan adalah pada konsentrasi 500 mg/mL, 400 mg/mL, 300 mg/mL, 200 mg/mL, 100 mg/mL, 50 mg/mL, 25 mg/mL, 10 mg/mL kloramfenikol 30 mg/ml dan blanko. Menggunakan metode disc diffusion untuk mengukur zona bening terhadap bakteri Staphylococcus aureus, Escherichia coli, Staphylococcus epidermidis, dan Salmonella typhi. Daya hambat antimikroba ekstrak etanol daun nangka (Artocarpus heterophyllus Lamk.) terhadap bakteri Staphylococcus aureus pada konsentrasi 500 mg/mL memiliki daya hambat antibakteri yang kuat dengan diameter 10,8 mm. Bakteri Escherichia coli, Staphylococcus epidermidis, dan Salmonella typhi pada konsentrasi 500 mg/mL memiliki daya hambat, 9,2 mm, 9,6 mm, dan 8,8 mm dengan kategori sedang. Kontrol  positif yaitu kloramfenikol memiliki daya hambat antibakteri yang sangat kuat dengan diameter zona hambat 28,6 mm. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-01-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/28 10.36490/journal-jps.com.v2i2.28 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 49-54 2656-3088 10.36490/journal-jps.com.v2i2 ind https://www.journal-jps.com/index.php/jps/article/view/28/24 10.36490/journal-jps.com.v2i2.28.g24 Copyright (c) 2020 Kasta Gurning, Dameria Siahaan, Iksen Iksen http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/29 2021-03-04T15:43:50Z jps:ART driver

Inhibitory Test Of Lime Juice (Citrus hystrix) Shampoo On The Microsporum gypseum Uji Daya Hambat Sediaan Sampo Air Perasan Jeruk Purut (Citrus hystrix) Terhadap Pertumbuhan Microsporum gypseum Maimunah, Siti Zega, Rita Marthalena sapitri, Alfi The shampoo is a dosage material used as a hair cleanser and epicarp head, especially the problem of dandruff caused by fungus. Kaffir lime has the content of essential oils, flavonoids and tannins are efficacious as an antifungal. The purpose of this study was to test the shampoo of kaffir lime and to know its inhibitory power to growth of Microsporum gypseum fungus. The type of this research is experiment with using agar diffusion method. Samples studied were epicarp juice of lime and mesocarp of kaffir lime with concentration respectively 10%, 20%, 30%, 40%, 50%. Shampoo dosage evaluation tests include inhibitory test, organoleptic test, pH test, high foam test and wetting test. The results showed that the lime mesocarp juice had inhibitory at 10% (13,09 mm) concentration, 20% (14,9 mm) concentration, 30% (18,52 mm) concentration, 40% concentration (20,86 mm ) and a concentration of 50% (22.53 mm). While the results of epicarp water of lime juice have a weak inhibitory power with a concentration of 10% (5,66 mm), Concentration of 20% (7,09 mm), concentration of 30% (8,09 mm), concentration of 40% (10,19), and concentration of 50% (11,36). Effective concentration on the preparation of shampoo preparations is the concentration of 20% and 30% of the lime juice mesocarp juice. The results of the evaluation test of two anti-dandruff shampoo formulations meet the requirements of a good shampoo and have respective inhabitants of F1 (20%) has a resistance of 14,54 mm and F2 (30%) has a resistance of 19,12 mm. Both dosage preparations are anti-dandruff. Sampo merupakan bahan sediaan yang digunakan sebagai pembersih rambut dan epicarp kepala terutama masalah ketombe yang disebabkan oleh jamur. Buah jeruk purut memiliki kandungan senyawa minyak atsiri, flavonoid dan tanin yang berkhasiat sebagai antijamur. Tujuan penelitian ini untuk menguji sampo dari jeruk purut dan mengetahui daya hambatnya terhadap pertumbuhan jamur Microsporum gypseum. Jenis penelitian ini adalah eksperimen dengan menggunakan metode difusi agar. Sampel yang diteliti adalah air perasan epicarp jeruk purut dan mesocarp jeruk purut dengan konsentrasi masing-masing 10%, 20%, 30%, 40%, 50%. Uji evaluasi sediaan sampo meliputi uji daya hambat, uji organoleptis, uji pH, uji tinggi busa dan uji waktu membasahi. Hasil penelitian menunjukkan air perasan mesocarp jeruk purut memiliki daya hambat pada konsentrasi 10% (13,09 mm), konsentrasi 20% (14,9 mm), konsentrasi 30% (18,52 mm), konsentrasi 40% (20,86 mm) dan konsentrasi 50% (22,53 mm). Sedangkan hasil dari air perasan epicarp jeruk purut memiliki daya hambat yang lemah dengan konsetrasi 10% (5,66 mm), Konsentrasi 20% (7,09 mm), konsentrasi 30% (8,09 mm), konsentrasi 40% (10,19), dan konsentrasi 50% (11,36). Konsentrasi efektif pada pembuatan sediaan sampo adalah konsentrasi 20% dan 30% dari air perasan mesocarp buah jeruk purut. Hasil uji evaluasi sediaan dari dua formulasi sampo anti ketombe memenuhi persyaratan sampo yang baik dan mempunyai daya hambat masing-masing yaitu F1(20%) memiliki daya hambat 14,54 mm dan F2(30%) memiliki daya hambat 19,12 mm. Kedua sediaan sampo bersifat anti ketombe. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-01-17 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/29 10.36490/journal-jps.com.v2i2.29 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 55-62 2656-3088 10.36490/journal-jps.com.v2i2 ind https://www.journal-jps.com/index.php/jps/article/view/29/25 10.36490/journal-jps.com.v2i2.29.g25 Copyright (c) 2020 Siti Maimunah, Rita Marthalena Zega, Alfi sapitri http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/30 2021-03-04T15:43:51Z jps:ART driver

The Influence of Life Style on Employee Nutritional Status of Health Polytechnic Directorate Health Ministry Medan Pengaruh Gaya Hidup Terhadap Status Gizi Pegawai Direktorat Politeknik Kesehatan Kementerian Kesehatan Medan Siregar, Emi Inayah Sari Lifestyle as one of the factors indirectly plays an important role in influencing nutritional status. The objective of this research was to find out the influence of lifestyle on nutritional status. The research used a cross-sectional design. The sample was 70 employees of Health Polytechnic Directorate, Health Ministry Medan, and taken by using a total sampling technique. The measured factors were eating patterns (adequate carbohydrate and fat intake, the type of food, and the frequency of eating), physical activity, sleep duration, and nutritional status. The data were obtained based on the measurement of BMI and interviews with using food recall, FFQ and questionnaires, then analyzed by using the chi-square test and logistic regression test in order to identify the most dominant factors which influence the nutritional status. The results of the research showed that there was a sufficient effect of carbohydrate intake (p < 0.001), adequate fat intake (p = 0.022), physical activity (p < 0.001) and sleep duration (p < 0.001) on the nutritional status. The results of the logistic regression test showed that the most dominant factor in influencing the nutritional status was the amount of carbohydrate intake.  Gaya hidup sebagai salah satu faktor tidak langsung, memegang peranan penting dalam mempengaruhi status gizi. Tujuan penelitian ini yaitu mengetahui pengaruh gaya hidup terhadap status gizi. Desain penelitian menggunakan cross sectional dengan sampel pegawai Direktorat Kesehatan Politeknik Kesehatan Kementerian Kesehatan Medan sebanyak 70 sampel. Metode penarikan sampel menggunakan total sampling. Faktor-faktor yang diukur adalah pola makan (kecukupan asupan karbohidrat dan lemak, jenis makanan dan frekuensi makan), aktivitas fisik, durasi tidur dan status gizi. Data dianalisis dengan menggunakan uji chi-square dan uji regresi logistik untuk mengidentifikasi faktor yang paling dominan dalam mempengaruhi  status gizi responden.Hasil penelitian menunjukkan bahwa ada pengaruh kecukupan asupan karbohidrat (p=0,000), kecukupan asupan lemak (p=0,022), aktivitas fisik (p=0,000) dan durasi tidur (p=0,000) dengan kejadian obesitas. Hasil uji regresi logistik menunjukkan bahwa faktor yang paling dominan dalam mempengaruhi status gizi yaitu jumlah asupan karbohidrat. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-12-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/30 10.36490/journal-jps.com.v2i2.30 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 29-35 2656-3088 10.36490/journal-jps.com.v2i2 ind https://www.journal-jps.com/index.php/jps/article/view/30/21 10.36490/journal-jps.com.v2i2.30.g21 Copyright (c) 2019 Emi Inayah Sari Siregar http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/33 2021-03-04T15:43:50Z jps:ART driver

Anti-Inflamatory Activity and Cyclooxygenase-2 Inhibition of ethanol extract from Malur Leaves (Brucea javanica (L.) Merr) Uji Aktivitas Anti-inflamasi Dan Daya Hambat Siklooksigenase-2 ekstrak etanol Daun Malur (Brucea javanica (L.) Merr.) Ifora, Ifora Haryani, Diana Abdillah, Rahmad Inflammation is a normal protective response to tissue damage mediated by Cyclooxigenase-2 (COX-2) enzyme. This study aims to determine the anti-inflammatory activity ethanol extract of (Brucea javanica (L.) Merr.) and its inhibitory effect on COX-2 enzyme. The animals used in this study were male white rats which were divided into 5 groups, dose250 mg/kg BB, dose 500 mg/kg BB, comparative control (Celecoxib), positve control and negative controls. Determining of anti-inflammatory activity was carried out by inducing the soles of the Rats with carragen and then measuring the edema volume using a pletismometer and measuring COX-2 inhibiton using a microplate Reader. The results showed that the ethanol extract of malur leaves doses 250 mg/kg BB and 500 mg/kg BB had significant anti-inflammatory activity (p <0.05). The dose 500 mg/kg BB has a significant inhibitory effect on COX-2 (p <0.05), but dose 250 mg/kg BB does not have significant inhibitory effect on COX-2. It can be concluded that the ethanol extract of malur leaves has anti-inflammatory effects at doses 250 mg/kg BB and 500 mg/kg BB and inhibitory effect against COX-2 at a dose 500 mg/kg BB. Inflamasi merupakan suatu respon protektif normal terhadap kerusakan jaringan yang dimediasi oleh enzim siklooksigenase-2 (COX-2). Penelitian ini bertujuan untuk melihat aktivitas antiinflamasi ekstrak etanol daun malur (Brucea javanica (L.) Merr.) dan daya hambatnya terhadap enzim COX-2. Hewan yang digunakan pada penelitian ini ialah tikus putih jantan yang dibagi menjadi 5 kelompok yaitu dosis 250 mg/kg BB, dosis 500 mg/kg BB, pembanding (Celecoxib), kontrol positif dan kontrol negatif. Pengujian aktivitas antiinflamasi dilakukan dengan cara menginduksi telapak kaki tikus dengan karagen kemudian diukur volume udemnya menggunakan pletismometer dan pengukuran daya hambat COX-2 menggunakan microplate readers. Hasil uji analisis menunjukkan bahwa ekstrak etanol daun malur dosis 250 mg/kg BB dan 500 mg/kg BB memiliki aktivitas antiinflamasi secara signifikan (p < 0,05). Dosis 500 mg/kg BB memiliki daya hambat terhadap COX-2 secara signifikan (p < 0,05) sedangkan dosis 250 mg/kg BB tidak memiliki daya hambat terhadap COX-2 secara signifikan. Dapat disimpulkan bahwa ekstrak etanol daun malur memiliki efek antiinflamasi pada dosis 250 mg/kg BB dan 500 mg/kg BB dan daya hambat terhadap COX-2 pada dosis 500 mg/kg BB. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-06-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/33 10.36490/journal-jps.com.v3i1.33 Journal of Pharmaceutical And Sciences; Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020); 7-13 2656-3088 10.36490/journal-jps.com.v3i1 ind https://www.journal-jps.com/index.php/jps/article/view/33/27 10.36490/journal-jps.com.v3i1.33.g27 Copyright (c) 2020 Ifora Ifora http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/34 2020-10-01T17:41:58Z jps:ART driver

PROFILE OF PHYTOCHEMISTRY COMPOUNDS METABOLITE SECONDARY EXTRACT OF SOUTH FLOWER EXTRACT   (Melastoma malabathricum L) PROFIL FITOKIMIA SENYAWA METABOLIT SEKUNDER EKSTRAK ETANOL BUNGA SENDUDUK (Melastoma malabathricum L) Noviyanty, Yuska Linda, Asri Mei Indonesia is one of the countries that has a diversity of drugs in the world. Indonesia's tropical forest area has the second highest biodiversity in the world after Brazil. Plant (Melastoma malabathricum L) is one of the natural ingredients that can be used as traditional medicine. this study was to identify secondary metabolites contained in the extract of senduduk flower ethanol (Melastoma malabathricum L).Extraction was carried out by maceration using 96% ethanol for 7 days. The extraction obtained is then concentrated with a rotary evaporator. Secondary metabolite content was identified by flavonoid color reaction tested with Mg and HCL reagents, alkaloids were tested with mayer, dragendrof, and Wagner saponin tested by foam reaction, tannin was tested with Fecl3 reagent and triterpenoid / steroid was tested with anhydrous acetic acid reaction. Then the assertion test was carried out using thin layer chromatography (TLC).The results showed that a positive color change was shown in the presence of flavonoids, tannins, and saponins, and based on the results of the assertion test, the pleated layer chromatography test (TLC) showed positive results of flavonoids, saponins. Indonesia merupakan salah satu negara yang memiliki keanekaragaman obat didunia. Wilayah hutan tropis indonesia memiliki keanekaragaman hayati tettinggi ke-2 didunia setelah Brazil. Tanaman senduduk (Melastoma malabathricum L) merupakan salah satu bahan alami yang dapat digunakan sebagai obat tradisional. penelitian ini adalah untuk mengidentifikasi senyawa metabolit sekunder yang terkandung pada ekstrak etanol bunga senduduk (Melastoma malabathricum L). Ekstraksi dilakukan dengan cara maserasi  menggunakan pelarut etanol 96% selama 7 hari. Ekstraksi yang diperoleh kemudian dipekatkan dengan alat rotary evaporator. kandungan metabolit sekunder diidentifikasi dengan reaksi warna flavonoid diuji dengan reagen Mg dan HCL, alkaloid diuji dengan mayer, dragendrof, dan wagner saponin diuji dengan reaksi busa, tanin diuji dengan reagen Fecl3 dan triterpenoid/steroid diuji dengan reaksi asam asetat anhidrat. Kemudian dilakukan uji penegasan dengan menggunakan metode kromatografi lapis tipis (KLT). Hasil penelitian menunjukan adanya perubahan warna yang positif ditunjukkan dengan adanya mengandung flavonoid, tannin, dan saponin, dan berdasarkan hasil uji penegasan uji kromatografi lapis lipis (KLT) didapatkan hasil positif flavonoid, tannin, dan saponin.   Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-06-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/34 10.36490/journal-jps.com.v3i1.34 Journal of Pharmaceutical And Sciences; Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020); 1-6 2656-3088 10.36490/journal-jps.com.v3i1 ind https://www.journal-jps.com/index.php/jps/article/view/34/26 10.36490/journal-jps.com.v3i1.34.g26 Copyright (c) 2020 Yuska Noviyanty http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/35 2021-03-04T15:43:50Z jps:ART driver

Physicochemical Study of Betasianin and Antioxidant Activities of Red beet tubers (Beta vulgaris L.) STUDI FISIKOKIMIA BETASIANIN DAN AKTIVITAS ANTIOKSIDAN DARI UMBI BIT MERAH (Beta vulgaris L.) ASRA, RIDHO Yetti, Rina Desni Ratnasari, Desi Nessa, Nessa Red beet tubers (Beta vulgaris L.) contain 5-O-beta-glycoside betacyanin compounds which have many benefits. One of which is an antioxidant. Activity study, have been done antioxidant acting test from red beet tubers (Beta vulgaris L.) was extracted using the Ultrasonic Assisted Extraction (UAE) method using a water solvent and dried by freeze-drying method for 48 hours. Betacyanin was identified by thin-layer chromatography with Rf value 0.7166 and a wavelength of 535 nm analyzed by UV-Vis spectrophotometry. The FTIR spectrum shows that isolates contain functional groups that ware similar to betacyanin standard (Sigma Aldrich). Betasianin obtained in red beetroot extract with levels of 98.6474%. The red beetroot is stable at 40 °C and pH 5. Test its antioxidant activity using the DPPH method (1,1-diphenyl-2-picrylylhydrazyl) with a wavelength of 515.50 nm. The results of this study indicate the antioxidant activity from of red beet tubers (Beta vulgaris L.) with IC50 values of 21.8878 µg/mL, compared to IC50 values of vitamin C 7.1099 µg/mL. it can be concluded that the red beet tubers have a potent antioxidant activity (high antioxidant <50 µg / mL). Umbi bit merah (Beta vulgaris L.) mengandung senyawa betasianin 5-O-beta-glikosida yang memiliki banyak manfaat salah satunya sebagai antioksidan. Pada penelitian ini telah dilakukan uji antioksidan dari umbi bit merah (Beta vulgaris L.)  diekstraksi dengan metode Ultrasonic Assisted Extraction (UAE) menggunakan pelarut air dan dikeringkan dengan metode freeze drying selama 48 jam. Pengujian betasianin dilakukan dengan kromatografi lapis tipis dimana diperoleh nilai Rf = 0,7166 dan panjang gelombang 535 nm yang dianalisis dengan metode spektofotometri UV-Vis. Spektrum FT-IR menunjukan bahwa isolat mengandung gugus-gugus fungsi yang identik dengan betasianin standar (Sigms Alderich). Betasianin diperoleh dalam ekstrak umbi bit merah dengan kadar sebesar 98,6474 %. Umbi bit merah stabil pada suhu 40 °C dan pada pH 5. Uji aktivitas antioksidan menggunakan metode DPPH (1,1-diphenyl-2-picrylylhydrazyl) dengan panjang gelombang 515,50 nm. Hasil penelitian ini menunjukan adanya aktivitas antioksidan dari umbi bit merah (Beta vulgaris L.) dengan nilai IC50 21,8878 µg/mL dibandingkan dengan nilai IC50 vitamin C 7,1099 µg/mL. dapat disimpulkan bahwa umbi bit merah memiliki aktivitas antioksidan yang sangat kuat (antioksidan tinggi <50 µg/mL). Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-06-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/35 10.36490/journal-jps.com.v3i1.35 Journal of Pharmaceutical And Sciences; Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020); 14-21 2656-3088 10.36490/journal-jps.com.v3i1 ind https://www.journal-jps.com/index.php/jps/article/view/35/28 10.36490/journal-jps.com.v3i1.35.g28 Copyright (c) 2020 RIDHO ASRA, Rina Desni Yetti, Desi Ratnasari, Nessa Nessa http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/37 2021-03-04T15:43:50Z jps:ART driver

Physicochemical Study of Mangosteen (Garcinia mangostana L.) peel Extract as Coloring Agent in Tablet Formulation Studi Fisikokimia Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Sebagai Pewarna Pada Formulasi Tablet ASRA, RIDHO Rusdi, Rusdi Nofrianti, Riri The mangosteen peel (Garcinia mangostana L.) contains anthocyanin pigments, which has an important role in coloring. This study aims to determine the physicochemical properties of mangosteen peel extract (Garcinia mangostana L.) with two methods, which is an examination with UV-Vis and FTIR spectrophotometry. Then the extract was characterized, identified, and analyzed for its stability against temperature, pH, and applied as a coloring agent in the formulation of pharmaceutical preparations (tablets). The results showed that the yield of mangosteen peel extract obtained 13.0975 %, drying losses 5.2822 %, total ash content 14.488 %, acid insoluble ash content 0.684 %, water-soluble extract content 29.58 %, extract content dissolved in ethanol 37.78 %, total anthocyanin content with λmax = 367 nm which is = 9.58 mg / 100 g and with λmax = 289 nm which is = 52.43 mg / 100 g. In this study, the anthocyanin pigment content in mangosteen peel extract cannot be used as an alternative to natural dyes for pharmaceutical preparations (tablets). Kulit buah manggis (Garcinia mangostana L.) mengandung pigmen antosianin yang berperan penting dalam pewarnaan. Penelitian ini bertujuan untuk mengetahui sifat fisikokimia ekstrak kulit buah manggis (Garcinia mangostana L.) dengan dua metode yaitu pemeriksaan dengan spektrofotometri UV-Vis dan FTIR. Kemudian ekstrak dikarakterisasi, diidentifikasi, dan dianalisa stabilitasnya terhadap suhu dan pH, serta diaplikasikan sebagai coloring agent pada formulasi sediaan farmasi (tablet). Hasil penelitian menunjukan bahwa rendemen ekstrak kulit buah manggis didapatkan 13,0975 %, susut pengeringan 5,2822 %, kadar abu total 14,498 %, kadar abu tidak larut asam 0,684 %, kadar sari yang larut dalam air 29,58 %, kadar sari yang larut dalam etanol 37,78 %, kadar total antosianin dengan λmax = 367 nm yaitu = 9,58 mg/100g dan dengan λmax = 289 nm yaitu = 52,43 mg/100g. Pada penelitian ini kandungan pigmen antosianin di dalam ekstrak kulit buah manggis, tidak dapat menjadi alternatif penggunaan pewarna alami untuk sediaan farmasi (tablet) Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-06-28 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/37 10.36490/journal-jps.com.v3i1.37 Journal of Pharmaceutical And Sciences; Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020); 22-32 2656-3088 10.36490/journal-jps.com.v3i1 ind https://www.journal-jps.com/index.php/jps/article/view/37/29 10.36490/journal-jps.com.v3i1.37.g29 Copyright (c) 2020 Ridho Asra, Rusdi Rusdi, Riri Nofrianti http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/38 2021-03-04T15:43:50Z jps:ART driver

NANOEMULSION FORMULATION OF TURMERIC EXTRACT (Curcuma longa L.) AS AN ANTIOXIDANT FORMULASI NANOEMULSI EKSTRAK KUNYIT (Curcuma longa L.) SEBAGAI ANTIOKSIDAN Larasati, Shinta Putri Jusnita, Nina Turmeric (Curcuma longa L.) is a plant commonly used as traditional medicine by the community. Curcumin from turmeric is known to have bioactive compounds that have antioxidant properties but have low solubility and bioavailability activity. Nanoemulsion was made to improve stability andbioavailability of turmeric (Curcuma longa L.). The preparation of nanoemulsion were use homogenization method at 30° C and 10° C. The extract concentration used was 30% and Tween 3% as an emulsifier. The results of this study indicate that the nanoemulsion particle size at a temperature of 30°C has a smaller size of 18.1 nm. The antioxidant activity of turmeric extract nanoemulsion preparations had IC50 of 31.16%, and 32.11%. This result is higher than the extract that is equal to 30.01%. Turmeric extract nanoemulsion is stable at high storage 40°C, and the solubility of nanoemulsion is increased Kunyit (Curcuma longa L.) merupakan tanaman yang biasa digunakan sebagai obat tradisional oleh masyarakat. Kurkumin dari kunyit diketahui mempunyai senyawa bioaktif yang berkhasiat sebagai antioksidan tetapi kelarutan dan bioavailabilitasnya rendah. Untuk memperbaiki sifat tersebut, maka dibuatlah kunyit (Curcuma longa L.) dalam formulasi baru berbentuk nanoemulsi. Penelitian ini menggunakan metode homogenisasi inversi suhu 30°C dan 10°C. Konsentrasi ekstrak yang digunakan sebanyak 30% dan Tween 3% sebagai emulsifier. Hasil penelitian ini menunjukkan bahwa ukuran partikel nanoemulsi pada pembuatan suhu 30°C memiliki ukuran lebih kecil yaitu 18,1 nm. Aktivitas antioksidan dari sediaan nanoemulsi ekstrak kunyit memiliki IC50 sebesar 31,16% dan 32,11%. Hasil ini lebih besar dibanding ekstrak yaitu sebesar 30,01%. Sediaan nanoemulsi ekstrak kunyit stabil pada penyimpanan 40°C serta kelarutannya meningkat Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/38 10.36490/journal-jps.com.v3i1.38 Journal of Pharmaceutical And Sciences; Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020); 33-41 2656-3088 10.36490/journal-jps.com.v3i1 ind https://www.journal-jps.com/index.php/jps/article/view/38/30 10.36490/journal-jps.com.v3i1.38.g30 Copyright (c) 2020 Shinta Putri Larasati, Nina Jusnita http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/41 2021-10-04T12:33:08Z jps:ART driver

Selection of Scabicide in Treating Scabies Pemilihan Skabisida dalam Pengobatan Skabies Trasia, Reqgi First Scabies is a skin infection caused by the Sarcoptes scabiei mite. In 2017, WHO included scabies in the list of neglected tropical diseases. Treatment of scabies is currently still having problems due to incorrect drug selection. The difficulty of diagnosing scabies has made the drugs prescribed were not appropriate. The purpose of this article is to discuss the types of scabicide that can be used and to review the advantages and disadvantages of using them. Scabies can be treated with scabies, such as sulfur presipitatum, gamma benzene hexachloride, benzyl benzoate, crotamitone, permethrin, ivermectin, and herbal therapy. Of these several scabies, permethrin is the most widely used drug due to its higher efficacy. It is hoped that this article will become a reference for clinicians in choosing the right scabicide for patients. Skabies merupakan penyakit infeksi kulit yang disebabkan oleh tungau Sarcoptes scabiei. Pada tahun 2017, WHO memasukkan skabies ke dalam daftar neglected tropical disease. Pengobatan skabies saat ini masih mengalami kendala karena kesalahan pemilihan obat. Sulitnya penegakan diagnosis skabies menyebabkan obat yang diresepkan pun tidak tepat. Tujuan dari artikel ini adalah untuk membahas jenis-jenis skabisida yang dapat digunakan serta meninjau kelebihan dan kekurangan dalam penggunaannya. Skabies dapat diobati dengan skabisida, seperti sulfur presipitatum, gama benzen heksaklorida, benzil benzoat, krotamiton, permetrin, ivermektin, dan terapi herbal. Dari beberapa skabisida tersebut, permetrin adalah obat yang paling banyak digunakan karena efikasinya yang lebih tinggi. Artikel ini diharapkan dapat menjadi acuan para klinisi dalam memilih skabisida yang tepat bagi penderita. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-11-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/41 10.36490/journal-jps.com.v3i2.41 Journal of Pharmaceutical And Sciences; Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020); 58-63 2656-3088 10.36490/journal-jps.com.v3i2 ind https://www.journal-jps.com/index.php/jps/article/view/41/34 10.36490/journal-jps.com.v3i2.41.g34 Copyright (c) 2020 Reqgi First Trasia http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/42 2021-10-04T12:33:08Z jps:ART driver

Isolation and Antibacterial Activity Test of The Extract Ethyl Acetate of Endophytic Fungi from Kencur (Kaempferia Galanga L.) Isolasi dan Uji Aktivitas Antibakteri Ekstrak Etil Asetat Jamur Endofit Kencur (Kaempferia Galanga L.) Efendi, M. Rifqi Rusdi, Mesa Sukmadani Anisa, Fitria The aim of this research was to isolate the endophytic fungi found in leaves and rhizomes of Kaempferia galanga L. and to test its antibacterial activity. Isolation of endophytic fungi is carried out by cultivating and sub-cultivating fungi that found in leaves and rhizomes of Kaempferia galanga L.  Identification of endophytic fungi is done by its morphology macroscopically and microscopically. Antibacterial activity testing is carried out  by using the agar diffusion method. From the leaves and rhizome of Kaempferia galanga L., five isolates of endophytic fungi were identified as Torulla sp. (KG001), Mucor sp. (KG002), Fusarium sp. (KG003), Geotricum sp. (KG004), and Drechslera sp. (KG005). Three ethyl acetate extracts of the endophytic fungi Torulla sp. (KG001), Fusarium sp. (KG003), and Drechcera sp. (KG005) had antibacterial activity against Gram positive (Staphylococcus aureus and Vibrio cholera) and Gram negative bacterias (Bacillus subtilis and Eschericia coli)  at concentration of 3.75%. The ethyl acetate extract endophytic fungi that had strong antibacterial activity (10-20 mm in diameter) were Torulla sp. (KG001) and Drechslera sp. (KG005). Meanwhile, the endophytic fungi that had moderate antibacterial activity (inhibition diameter 5-10 mm) was the ethyl acetate extract Fusarium sp. (KG003).The strongest antibacterial activity was shown by the ethyl acetate extract Drechslera Sp. with an inhibitory diameter 16 mm against Vibrio cholera . Penelitian ini bertujuan untuk mengisolasi jamur endofit yang terdapat pada daun dan rimpang kencur (Kaempferia galanga L.) serta menguji aktivitas antibakterinya. Isolasi jamur endofit dilakukan dengan kultivasi dan subkultivasi jamur yang tumbuh dari daun dan rimpang kencur (Kaempferia galanga L.) yang sebelumnya telah disterilkan pada media potato dextrose agar (PDA). Identifikasi jamur endofit dilakukan secara makroskopis dan mikroskopis terhadap morfologinya. Pengujian aktivitas antibakteri dilakukan menggunakan metode difusi agar. Dari daun dan rimpang kencur diperoleh lima isolat jamur endofit  yang diidentifikasi sebagai Torulla sp. (KG001), Mucor sp. (KG002), Fusarium sp. (KG003), Geotricum sp. (KG004), dan Drechslera sp. (KG005). Tiga ekstrak etil asetat jamur endofit Torulla sp. (KG001), Fusarium sp. (KG003), dan Drechcera sp. (KG005) memiliki aktivitas sebagai antibakteri terhadap bakteri Gram positif  (Staphylococcus aureus and Vibrio cholera) dan Gram negatif (Bacillus subtilis and Eschericia coli) pada konsentrasi 3.75 %. Jamur endofit yang memiliki aktivitas antibakteri kuat (diameter hambat 10-20 mm) adalah Torulla sp. (KG001) dan Drechslera sp. (KG005). Sedangkan, jamur endofit yang memiliki aktivitas antibakteri sedang (diameter hambat 5-10 mm) adalah ekstrak etil asetat jamur Fusarium sp. (KG003). Aktivitas antibakteri terbesar ditunjukkan oleh ekstrak etil asetat isolat jamur Drechslera Sp. dengan diameter hambat 16 mm terhadap bakteri uji Vibrio cholera. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-11-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/42 10.36490/journal-jps.com.v3i2.42 Journal of Pharmaceutical And Sciences; Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020); 85-92 2656-3088 10.36490/journal-jps.com.v3i2 ind https://www.journal-jps.com/index.php/jps/article/view/42/37 10.36490/journal-jps.com.v3i2.42.g37 Copyright (c) 2020 M. Rifqi Efendi, Mesa Sukmadani Rusdi, Fitria Anisa http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/43 2021-03-04T15:43:50Z jps:ART driver

APHRODISIAC EFFECTIVENESS TEST ETHANOL EXTRACT ALBEDO (MESOCARP) WATER MELON (Citrullus lanatus (Thunb.) Matsumura & Nakai) ON Mice (Mus musculus) UJI EFEKTIVITAS AFRODISIAKA EKSTRAK ETANOL ALBEDO (MESOCARP) SEMANGKA (Citrullus lanatus (Thunb.) Matsumura & Nakai) PADA MENCIT (Mus musculus) Gunawan, Muhammad Saputri, Muharni Sari, Suci Indah Sexual dysfunction is a condition where sexual intercourse is difficult. Sexual dysfunction includes erectile dysfunction, impotence, premature ejaculation and disorders of desire (libido). One of the ways to overcome sexual disorders is by using aphrodisiac. Aphrodisiac is a kind of stimulating substance that can increase sex drive. One of the fruits that has an aphrodisiac effect is watermelon, precisely on the white layer on the skin that contains citrulline. This study aims to determine the aphrodisiac potential and the number of effective doses of watermelon albedo (mesocarp) ethanol extract (WAEE) against mice using ICC (Introducing, Climbing and Coitus). This research is an experimental study using 30 mice and divided into 5 groups. Group I (negative control) CMC 0.5%; group II (positive control) Pasak Bumi herbal medicine; group III; IV; V WAEE at a dose of 7; 13; and 27 g / kgBB. The mice were given orally and the ICC intensity was calculated. ICC intensity was statistically analyzed using the One Way ANOVA method and Duncan's Post-Hoc test using SPSS 24.0. The results of the ICC intensity statistical test between the Pasak Bumi herbal medicine and EEAS groups showed no significant difference with a value of α> 0.05. From the results of the study it can be concluded that EEAS has the potential as an aphrodisiac in mice with the most effective dose of 13 g / kgBW. Disfungsi seksual merupakan suatu keadaan yang mengalami kesulitan dalam berhubungan seksual. Disfungsi seksual meliputi disfungsi ereksi, impotensi, ejakulasi dini dan gangguan hasrat (libido). Pengatasan gangguan seksual salah satunya dengan menggunakan afrodisiaka. Afrodisiaka merupakan semacam zat perangsang yang dapat meningkatkan gairah seks. Salah satu buah yang memiliki efek afrodisiaka yaitu buah semangka, tepatnya pada lapisan putih pada kulit yang mengandung sitrulin. Penelitian ini bertujuan untuk mengetahui potensi afrodisiaka dan jumlah dosis yang efektif dari ekstrak etanol albedo (mesocarp) semangka (EEAS) terhadap mencit dengan menggunakan ICC (Introducing, Climbing and Coitus).  Penelitian ini merupakan penelitian eksperimental dengan menggunakan 30 ekor mencit dan dibagi menjadi 5 kelompok. Kelompok I (kontrol negatif) CMC 0,5 %; kelompok II (kontrol positif) jamu pasak bumi; kelompok III; IV;V EEAS dengan dosis 7; 13;  dan 27 g/kgBB. Pemberian pada mencit secara oral dan dihitung intensitas ICC. Intensitas ICC dianalisis secara statistik menggunakan metode One Way ANOVA dan uji Post-Hoc Duncan menggunakan SPSS 24.0. Hasil uji statistik intensitas ICC antara kelompok jamu pasak bumi dan EEAS menunjukkan tidak ada perbedaan yang signifikan dengan nilai α > 0,05. Dari hasil penelitian dapat disimpulkan bahwa EEAS berpotensi sebagai afrodisiaka pada mencit dengan dosis yang paling efektif sebesar 13 g/kgBB. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-07-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/43 10.36490/journal-jps.com.v3i1.43 Journal of Pharmaceutical And Sciences; Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020); 42-50 2656-3088 10.36490/journal-jps.com.v3i1 ind https://www.journal-jps.com/index.php/jps/article/view/43/31 10.36490/journal-jps.com.v3i1.43.g31 Copyright (c) 2020 Muhammad Gunawan http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/44 2021-10-04T12:33:08Z jps:ART driver

REVIEW: EXCIPIENTS FOR TABLET MANUFACTURING WITH DIRECT COMPRESSION METHOD REVIEW: EKSIPIEN UNTUK PEMBUATAN TABLET DENGAN METODE KEMPA LANGSUNG Sulaiman, Teuku Nanda Saifullah Sulaiman, Salman Tablets are very popular in a pharmaceutical dosage form. Tablet preparations can be made in various ways, including by direct compression methods, wet granulation, dry granulation, fast melt granulation, and foam granulation. Each of these methods has advantages and disadvantages. The direct compression methods have the advantages of a fast process that only requires mixing and compressing. Not all active ingredients can be directly compressed because they have a weakness in the flow properties and less compressible. The direct compression process requires additional materials or excipients called filler-binders. This review article will discuss the development of excipients for the manufacture of tablets by direct compression. At present, there are many excipients for direct compression in the market, with various advantages. The excipient is a co-processed material developed from the original material which cannot be used for direct compression excipients. Various co-processing that is done at the end will produce new materials that have better properties. With the availability of various types of direct compression excipients, the formulator has a variety of choices to be applied in the formulas designed. This will provide flexibility in selecting excipients to be applied to various active substances so that they will produce a dosage form with good quality. Tablet merupakan salah satu bentuk sediaan farmasi yang sangat popular. Sediaan tablet dapat dibuat dengan berbagai cara, diantaranya dengan metode kempa langsung, granulasi basah, granulasi kering, fast melt granulation, dan foam granulation. Masing-masing metode tersebut memiliki kelebihan dan kelemahan. Metode kempa langsung memiliki kelebihan pada prosesnya yang cepat yaitu hanya membutuhkan proses pencampuran dan pengempaan. Tidak semua bahan aktif dapat langsung dikempa karena memiliki kelemahan pada sifat alirnya yang jelek dan tidak kompresibel. Proses kempa langsung memerlukan bahan tambahan atau eksipien yang disebut filler-binder. Artikel review ini akan mendiskusikan tentang perkembangan eksipien untuk pembuatan tablet secara kempa langsung. Saat ini banyak eksipien kempa langsung yang ditawarkan di pasar, dengan berbagai keunggulannya. Eksipien tersebut merupakan material co-processed yang dikembangkan dari material asal yang tidak dapat digunakan untuk eksipien kempa langsung. Berbagai co-processing yang dilakukan pada akhir akan menghasilkan material baru yang memiliki sifat-sifat yang lebih baik. Dengan tersedianya berbagai jenis eksipien kempa langsung, maka formulator memiliki pilihan yang beragam untuk diaplikasikan dalam formula yang dirancang. Hal ini akan memberikan keleluasaan dalam memilih eksipien untuk diaplikasikan pada berbagai zat aktif sehingga akan menghasilkan sediaan yang bermutu. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-11-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/44 10.36490/journal-jps.com.v3i2.44 Journal of Pharmaceutical And Sciences; Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020); 64-76 2656-3088 10.36490/journal-jps.com.v3i2 ind https://www.journal-jps.com/index.php/jps/article/view/44/35 10.36490/journal-jps.com.v3i2.44.g35 Copyright (c) 2020 Teuku Nanda Saifullah Sulaiman, Salman Sulaiman http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/45 2021-03-04T15:43:50Z jps:ART driver

ANTIBACTERIAL ACTIVITY MOUTHWASH PREPARATION ETHANOL EXTRACT OF CARDAMOM (Amomum compactum Sol. ex Maton) FOR GROWTH OF BACTERIA Staphylococcus aureus AND Streptococcus mutans UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR EKSTRAK ETANOL BUAH KAPULAGA (Amomum compactum Sol. ex Maton) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus DAN Streptococcus mutans Mierza, Vriezka Sudewi, Sudewi Local cardamom (Amomumcompactum Sol. Ex Manton) is able to inhibit the growth of fungi and cineol compounds. Local cardamom which is anti-fungal and contains antibacterial properties. This study aims to determine the ethanol extract of cardamom fruit which is formulated into a mouthwash that can inhibit the growth of bacteria Staphylococcus aureusand Streptococcus mutans at certain concentrations. The method of this research is to test the antibacterial activity of Staphylococcus aureus and Streptococcus mutansfrom the ethanol extract of cardamom mouthwash. The preparation was evaluated for physical stability of storage for 4 weeks, pH test and antibacterial test. All cardamom fruit ethanol extract mouthwash preparations have a good physical form and are stable. At 4 weeks of storage, do not have the appropriate pH and antibacterial activity of cardamom fruit ethanol extract mouthwash against Staphylococcus aureus and Streptococcus mutans 2%, 4%, and 6% for Streptococcus mutans, the inhibition diameter was 9 mm, and 8 mm, while Staphylococcus aureus had the inhibition diameter 12 mm, 11 mm, and 10 mm, respectively. The results of this study concluded that the ethanol extract of cardamom fruit can be formulated into mouthwash with concentrations of 2%, 4%, and 6% which have moderate inhibition against Streptococcus mutans bacteria and have strong category inhibition against Staphylococcus aureus bacteria. Kapulaga lokal (Amomum compactum Sol. ex Manton) mampu menghambat pertumbuhan cendawan dan senyawa sineol. kapulaga lokal yang bersifat sebagai anticendawan dan mengandung antibakteri.Penelitian ini bertujuan untuk mengetahui ekstrak etanol buah kapulaga yang diformulasikan menjadi sediaan obat kumur yang dapat menghambat pertumbuhan bakteri Staphylococcus aureus dan Streptococcus mutanspada konsentrasi tertentu. Adapun metode dari penelitian ini adalah dengan menggunakan pengujian aktivitas antibakteri Staphylococcus aureus dan Streptococcus mutans dari sediaan obat kumur ekstrak etanol buah kapulaga.Sediaan dievaluasi stabilitas fisik penyimpanan selama 4 minggu, uji pH dan pengujian antibakteri. Seluruh sediaan obat kumur ekstrak etanol buah kapulaga yang dibuat memiliki bentuk fisik yang baik dan stabil pada penyimpanan selama 4 minggu, tidak memiliki pH yang sesuai dan hasil uji aktivitas antibakteri sedian obat kumur ekstrak etanol buah kapulaga dengan konsetrasi ekstrak 2%, 4%, dan 6% pada Streptococcus mutans, menghasikan diameter daya hambatnya berurut-turut 8,42 mm; 9,03 mm; dan 9,48 mm, sedangkan Staphylococcus aureus diameter daya hambatnya secara  berurutan  12 mm, 11 mm, dan 10 mm. Hasil penelitian ini menyimpulkan bahwa ekstrak etanol buah kapulaga dapat diformulasikan menjadi obat kumur  dengan konsentrasi 2%, 4%, dan 6% yang memiliki daya hambat kategori sedang terhadap bakteri  Streptococcus mutans dan  memiliki daya hambat kategori kuat terhadap bakteri Staphylococcus aureus. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-07-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/45 10.36490/journal-jps.com.v3i1.45 Journal of Pharmaceutical And Sciences; Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020); 50-57 2656-3088 10.36490/journal-jps.com.v3i1 ind https://www.journal-jps.com/index.php/jps/article/view/45/32 10.36490/journal-jps.com.v3i1.45.g32 Copyright (c) 2020 Vriezka Mierza http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/47 2021-10-04T12:33:08Z jps:ART driver

ANALYSIS OF HEAVY METAL POLLUTION (Pb) IN LIPSTIK ARE FOR SALE IN THE CITY OF BANDA ACEH ATOM ABSORPTION SPECTROFOTOMETRY ANALISIS CEMARAN LOGAM BERAT TIMBAL (Pb) PADA LIPSTIK YANG DIJUAL DI KOTA BANDA ACEH SECARA SPEKTROFOTOMETRI SERAPAN ATOM Fauziah, Fauziah Maulinda, Adyani Adriani, Azmalina One of the cosmetic preparations that have become the main cosmetics for women is lipstick. The lipstick used must be free from contamination, especially heavy metal contaminants such as lead (Pb). Requirements for the content of lead (Pb) in cosmetics according to BPOM RI Number Hk.03.1.23.07.11.6662 the Year 2011, do not exceed the threshold value of 20 mg/kg or 20 ppm. This study aims to measure the concentration of the heavy metal lead (Pb) in lipstick preparations measured in Banda Aceh City by atomic absorption spectrophotometry. The population in this study were all lipstick samples sold in the city of Banda Aceh. Lipstick sampling was carried out by a random sampling method, as many as five lipstick samples. The results showed that the lead levels in sample code 1 were 6.83 mg / kg, sample 2 was 0.12 mg / kg, sample 3 was 0.72 mg / kg, sample 4 was 2.99 mg / kg and sample 5 is 1.2 mg / kg. So it can be denied that of the five lipstick samples all of them meet the requirements, the threshold value of lead (Pb) contamination in the sample is still below 20 mg/kg or 20 ppm. Salah satu sediaan kosmetika yang telah menjadi kosmetika utama bagi para wanita adalah lipstik. Lipstik yang digunakan harus terbebas dari cemaran terutama cemaran logam berat seperti timbal (Pb). Persyaratan kandungan cemaran logam berat timbal (Pb) dalam kosmetik menurut BPOM RI Nomor Hk.03.1.23.07.11.6662 Tahun 2011, tidak melebihi nilai ambang batas sebesar 20 mg/kg atau 20 ppm. Penelitian ini bertujuan untuk mengetahui konsentrasi logam berat timbal (Pb) dalam sediaan lipstik yang beredar di Kota Banda Aceh secara spektrofotometri serapan atom. Populasi dalam penelitian ini yaitu sampel lipstik yang dijual dikota Banda Aceh, pengambilan sampel lipstik dilakukan dengan metode random sampling, sebanyak lima sampel lipstik. Hasil penelitian diperoleh kadar timbal bertutut-turut pada sampel kode sampel 1 yaitu 6,83 mg/kg, sampel 2 yaitu 0,12 mg/kg, sampel 3 yaitu 0,72 mg/kg, sampel 4 yaitu 2,99 mg/kg dan sampel 5 yaitu 1,2 mg/kg. Sehingga dapat disimpulkan bahwa dari lima sampel lipstik keseluruhannya memenuhi persyaratan, nilai ambang batas cemaran logam berat timbal (Pb) dalam sampel masih dibawah 20 mg/kg atau 20 ppm.   Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-11-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/47 10.36490/journal-jps.com.v3i2.47 Journal of Pharmaceutical And Sciences; Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020); 77-84 2656-3088 10.36490/journal-jps.com.v3i2 ind https://www.journal-jps.com/index.php/jps/article/view/47/36 10.36490/journal-jps.com.v3i2.47.g36 Copyright (c) 2020 Fauziah Fauziah http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/49 2022-03-09T10:19:26Z jps:ART driver

ANALYSIS OF CAUSES OF MEDICATION ERRORS IN PHASE PRESCRIBING OF POLICLINIC INTERNAL DISEASES H. ADAM MALIK GENERAL HOSPITAL ANALISIS PENYEBAB MEDICATION ERROR PADA FASE PRESCRIBING DI POLIKLINIK PENYAKIT DALAM RSUP H. ADAM MALIK Siahaan, Desy Natalia Roiman, Robert Silalahi, urminda Gunawan, Muhammad A medication error is an event that can jeopardize patient safety by health workers, especially in terms of patient treatment services that should be avoided. The occurrence of medication errors can occur in each treatment process, one of which is in the prescribing phase. The prescribing phase is the part when a doctor prescribes a patient's medication. The purpose of this study was to determine the causes and incidence of medication errors in the prescribing phase in the treatment services at H. Adam Malik General Hospital. This research is a prospective study or data collection that is new or ongoing. The research subjects were prescription internal medicine patients who met the inclusion and exclusion criteria with a total sampling method that took a prescription in 2018 at the Outpatient Pharmacy Working Group. The results of the study were obtained from 984 prescriptions for a medication error in the prescribing phase of 33.82%. There was no prescription address, doctor's SIP, date of birth, gender, patient weight, diagnosis, route of administration as much as 100% of the total prescription. Lack of dosage strength, dosage units 49 times each (4.98%), and errors did not write down the name of the complete medical device and the amount was 3 times (0.30%). The main cause is the unavailability of data filling formats or templates on the computer or in the MIRSA Enterprise® application that is used as a recipe management software. Medication error adalah suatu kejadian yang dapat membahayakan keselamatan pasien yang dilakukan oleh petugas kesehatan khususnya dalam hal pelayanan pengobatan pasien yang seharusnya dapat dihindari. Kejadian medication error dapat terjadi di dalam tiap proses pengobatan, salah satunya pada fase prescribing. Fase Prescribing adalah bagian pada saat dokter meresepkan obat pasien. Tujuan penelitian ini adalah mengetahui penyebab dan angka kejadian medication error pada fase prescribing dalam pelayanan pengobatan di RSUP H. Adam Malik. Penelitian ini merupakan penelitian prospektif atau pengambilan data yang baru atau sedang berlangsung. Subjek penelitian adalah resep pasien penyakit dalam yang memenuhi kriteria inklusi dan eksklusi dengan metode total sampling yang mengambil resep tahun 2018 di Pokja Apotek Rawat Jalan.  Hasi penelitian didapatkan dari 984 resep angka kejadian medication error pada fase prescribing sebesar 33,82%. Kejadian tidak ada alamat penulis resep, SIP dokter, tanggal lahir, jenis kelamin, berat badan pasien, diagnosa, rute pemberian sebanyak 100% dari total resep. Tidak adanya kekuatan sediaan, satuan dosis masing-masing sebanyak 49 kali kejadian (4,98%), dan kesalahan tidak menuliskan nama alat kesehatan secara lengkap serta jumlahnya sebanyak 3 kali (0,30%). Penyebab utama adalah tidak tersedianya format atau template pengisian data di komputer atau dalam aplikasi MIRSA Enterprise® yang digunakan sebagai Software pengolaan resep. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-06-13 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/49 10.36490/journal-jps.com.v2i1.49 Journal of Pharmaceutical And Sciences; Vol 2 No 1 (2019): JPS Volume 2 Nomor 1 (2019); 57-65 2656-3088 10.36490/journal-jps.com.v2i1 ind https://www.journal-jps.com/index.php/jps/article/view/49/33 10.36490/journal-jps.com.v2i1.49.g33 Copyright (c) 2019 Desy Natalia Siahaan http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/51 2021-10-04T12:33:08Z jps:ART driver

Antibacterial Activity Test of Ethanol Extract from Dried Simplicia Garlic (Allium sativum L.) Against Bacillus cereus Bacteria Athaillah, Athaillah Lestari, Ugi Diana This research is aimed to find out the extract activity dried simplisia of garlic (Allium sativum L.) as an antibacterial which is capable to inhibiting growth of Bacillus cereus bacterium, to find out the alkaloid secondary of metabolites, flavonoid, tannin and saponin that contained in dried extract of garlic and to find out a concentration that has the most antibacterial activity which is capable to inhibiting growth of Bacillus cereus bacterium. Garlic was extracted by maceration method using a solvent ethanol 96%. After the extract obtaned, then phtochemical screening and standardization test. Thickening technique by evaporation used vacum rotary evaporator until thick extarct was obtained. Antibacterial activity thest by using disk diffusion method. This research was used seven concentrations which were 20% (b/v), 30% (b/v). 40% (b/v), 50% (b/v), 60% (b/v), 80% (b/v)and100% (b/v). The result of phytochemical screening test, ethanol extract garlic (Allium sativum L.) positive contained compound alkaloid, flavonoid, saponin and tannin. Standardization of power simplisia fulfill the requirements set by Depkes RI 2000. The result of activity test of optimum antibacterial was obtained inhibitory power with the number 27 mm on 40% (b/v) concentration. This proves that garlic (Allium sativum L.) have antibacterial affects against Bacillus cereus bacterium Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/51 10.36490/journal-jps.com.v3i2.51 Journal of Pharmaceutical And Sciences; Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020); 93-99 2656-3088 10.36490/journal-jps.com.v3i2 ind https://www.journal-jps.com/index.php/jps/article/view/51/38 Copyright (c) 2021 Athaillah Athaillah, Ugi Diana Lestari http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/52 2021-10-04T12:33:08Z jps:ART driver

IDENTIFICATION AND DETERMINATION OF SAPONIN LEVELS FROM BIDURROT EXTRACT (Calotropis gigantea L) USING GRAVIMETRY METHOD IDENTIFIKASI DAN PENETAPAN KADAR SAPONIN DARI EKSTRAK AKAR BIDURI (Calotropis gigantea L) DENGAN METODE GRAVIMETRI Noviyanty, Yuska Noviyanty Herlina, Herlina Fazihkun, Cahyan Biduri plants (Calotropis gigantea L) are used as medicinal plants, namely as cough and anti-allergic medicines. Research conducted by (Suchita Siggn. 2014) shows the presence of glycoside compounds, saponins, alkaloids, flavonoids, and tannins. then the researchers are interested in carrying out research on the identification and determination of saponin levels from the extract of the baby root (Calotropis gigantea L) by the Gravimetri method. Qualitative test was carried out by inserting 500 mg of biduri root extract (Calotropis gigantea L) into a test tube, then adding 10 ml of hot water, shaking vigorously for 10 seconds and adding HCL, then a quantitative test was carried out using the gravimetric method. Based on the results of research that has been carried out the extract of the betel root (Calotropis gigante L) positive containing saponin compounds with saponin content is 2.6% with a weight of 1.16 gram saponins using the gravimetric method Tanaman biduri (Calotropis gigantea L) di manfaatkan sebagai tanaman obat yaitu sebagai obat batuk dan antialergi. Penelitian yang telah dilakukan oleh (Suchita Siggn .2014) menunjukan adanya senyawa glikosida, saponin, alkaloid, flavonoid, dan tanin. maka peneliti tertarik untuk mengangkat penelitian tentang identifikasi dan penetapan kadar saponin dari ekstrak akar biduri (Calotropis gigantea L)  dengan metode Gravimetri. Dilakukan uji kualitatif dimasukan 500 mg ekstrak akar biduri (Calotropis gigantea L) kedalam tabung reaksi, tambahkan 10 ml air panas, kocok kuat selama 10 detik dan tambahkan HCL, selanjutya  dilakukan uji kuantitatif metode gravimetri. Dari hasil penelitian telah dilakukan bahwa pada ekstrak akar biduri (Calotropis gigante L) positif  mengandung senyawa saponin dengan kadar saponin adalah 2,6% dengan bobot saponin 1,16 gram dengan menggunakan metode gravimetri Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/52 10.36490/journal-jps.com.v3i2.52 Journal of Pharmaceutical And Sciences; Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020); 100-105 2656-3088 10.36490/journal-jps.com.v3i2 ind https://www.journal-jps.com/index.php/jps/article/view/52/39 Copyright (c) 2021 Yuska Noviyanty http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/56 2022-03-14T11:08:03Z jps:ART driver

Test The Effectivnessof Saga Leaf Extract (Abrus precatorius Linn) Ointmentfor Wound Treatmentin Rabbits (Oryctolagus Cuniculus) Uji Efektivitas Sediaan Salep Ekstrak Daun Saga (Abrus precatorius Linn) Untuk Pengobatan Luka Pada Kelinci (Oryctolagus cuniculus) Rambe, Robiatun Paramitha, Ratih Ginting, Ernawaty Caniago, Mita Yusmira Lestari Saga leaf (abrus precatorius Linn) contained flavonoids, tannins, triterpenoids are able to provide an antibacterial effect. The purpose of the study was to made a balm extract from saga leaf (abrus precatorius Linn)and test the effectiveness of ointments against the treatment of wounds on rabbit skin. Proces of balm extract from saga leaf has qualified the standard and tested on rabbit with 5 treatment groups, is injuries without negative control, positive control, saga leaf ointment 10%, 20% and 30%. All the rabbit were sliced 1,5 cm long and given 0,2 mL of saga leaf extract ointment. The wounds were applied with ointment three times daily. Observations was conducted everyday for 8 days. The result shows differences that the saga leaf formulation meets the ointment test requirement according to farmakope Indonesia edition III, wounds were narrowed, scabs were formed and then wounds were closed. Daun saga (abrus precatorius Linn) memiliki kandungan flavonoid, tanin, triterpenoid yang mampu memberikan efek antibakteri.Penelitian ini bertujuan untuk membuat salep dari ekstrak daun saga (abrus precatorius Linn) dan uji efektivitas sediaan salep terhadap pengobatan luka pada kulit kelinci. Pembuatan salep ekstrak daun saga yang telah memenuhi syarat dan diujikan pada hewan uji kelinci sebanyak 5 ekor dengan perlakuan, dasar salep berlemak (kontrol negatif), gentamicin salep (kontrol positif), ekstrak daun saga 10%, 20% dan 30%. Semua kelinci disayat sepanjang 1,5cm dan diberikan sediaan salep ekstrak daun saga sebanyak 0,2 mL. Luka diolesi tiga kali sehari dengan salep yang diuji.Pengamatan luka dilakukan setiap hari selama 8 hari.Hasil penelitian menunjukkan formulasi salep ekstrak daun saga memenuhi persyaratan uji salep menurut Farmakope Indonesia edisi III.Luka sayat yang dioleskan salep ekstrak daun saga mengalami penyempitan luka, membentuk keropeng dan menutup luka mulai hari ke 3. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/56 10.36490/journal-jps.com.v5i1.56 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 111-116 2656-3088 10.36490/journal-jps.com.v4i2 ind https://www.journal-jps.com/index.php/jps/article/view/56/65 Copyright (c) 2021 Robiatun Rambe http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/57 2022-08-11T02:10:51Z jps:ART driver

ETHANOL EXTRACT ANALGESICS ACTIVITIES OF MAHKOTA DEWA LEAVES (Phaleria macrocarpa (Scheeff.) Boerl) FOR IN VIVO AKTIVITAS ANALGESIK EKSTRAK ETANOL DAUN MAHKOTA DEWA (Phaleria macrocarpa (Scheff.) Boerl) SECARA IN VIVO salman, salman Saputri, Muharni Mustika, Ika Pain is a feeling of discomfort caused by intense or destructive stimuli, which, if left untreated, can affect your daily routine. Pain can be treated with analgesics. One of the plants that are thought to have analgesic effects is the leaves of the mahkota dewa. The purpose of this study was to determine the analgesic effect and dosage of the ethanol extract of mahkota dewa leaves and to determine the effectiveness of the ethanol extract of the mahkota dewa leaves as an analgesic using the stretching method. The study began with the collection and processing of the leaves of the mahkota dewa into ethanol extract using the maceration method; then, the research was continued within in vivo analgesic activity testing of 25 mice that had been induced by pain using 1% acetic acid. The induced mice were divided into five treatment groups, where the mice in the first group served as a negative control group; in this group, they were given CMC at a dose of 0.5%. The second group of mice, which were positive controls, were given mefenamic acid at a dose of 500 mg. In contrast, in mice, the third, fourth, and fifth groups, which were the treatment group, were given ethanol extract of the leaves of mahkota dewa with consecutive doses of 0.25 g/kg BW, 0.50 g/kg BW, 0.75 g/kg BW. Parameters measuring the effectiveness of the extracts used in this study included the amount of stretching, the percentage of analgesic power, and analgesic effectiveness. The results showed that the positive control group had the highest percentage of analgesic power at 59.9%. At EEDMD 0.75 g/kg BW gained 55.5%. EEDMD at a dose of 0.25 g/kg BW obtained 46.33%. Furthermore, EEDMD at a dose of 0.50 g/kg BW amounted to 55.06%. Furthermore, the percent effectiveness showed that EEDMD 0.75 g/kg BW had the highest percentage effectiveness, namely 92.65%. Whereas at EEDMD 0.25 g/kg BW is 77.29% and in EEDMD 0.50 g/kg BW is 91.91%. Based on the results of statistical analysis using ANOVA, it was found that the ethanol extract of the leaves of the mahkota dewa dosage of 0.75 g / kg BW had analgesic activity close to 500 mg of mefenamic acid. Nyeri merupakan perasaan tidak nyaman yang disebabkan oleh rangsangan yang kuat atau merusak, jika dibiarkan dapat mempengaruhi rutinitas sehari-hari. Nyeri dapat ditangani dengan analgetika. Salah satu tumbuhan yang diduga mempunyai efek analgetik adalah daun mahkota dewa. Tujuan dari penelitian ini adalah untuk mengetahui efek analgesik dan dosis dari ekstrak etanol daun mahkota dewa, serta untuk mengetahui keefektifan Ekstrak Etanol Daun Mahkota Dewa sebagai analgesik dengan metode geliat. Penelitian dimulai dengan pengumpulan dan pengolahan daun mahkota dewa menjadi ekstrak etanol menggunakan metode maserasi, kemudian penelitian dilanjutkan dengan pengujian aktivitas analgesik secara in vivo pada 25 ekor mencit yang telah di induksi nyeri menggunakan asam asetat 1%. Mencit yang telah diinduksi tersebut dibagi menjadi lima kelompok perlakuan, dimana  kelompok pertama sebagai kontrol negatif diberikan CMC 0,5%, pada kelompok kedua sebagai kontrol positif diberikan asam mefenamat 500 mg, sedangkan pada kelompok ketiga, keempat dan kelima yang merupakan kelompok perlakuan ekstrak, diberikan ektrak etanol daun mahkota dewa dengan dosis berturut-turut sebesar 0,25 g/kgBB; 0,50 g/kgBB; 0,75 g/kgBB. Parameter pengukuran efektivitas dari ekstrak yang digunakan dalam penelitian ini meliputi jumlah geliat, persentase daya analgesik dan persentase efektivitas analgesik. Hasil penelitian menunjukkan kelompok kontrol positif memiliki persentase daya analgesik yang tertinggi dengan jumlah 59,9%. Pada EEDMD 0,75 g/kg BB memperoleh 55,5%. EEDMD dosis 0,25 g/kg BB memperoleh 46,33%. dan EEDMD dosis 0,50 g/kg BB jumlah 55,06%. Hasil persen efektivitas menunjukkan pada EEDMD 0,75 g/kgBB mempunyai persen efektivitas tertinggi yaitu 92,65%, sedangkan pada EEDMD 0,25 g/kg BB yaitu 77,29% dan pada EEDMD 0,50 g/kg BB yaitu 91,91%. Berdasarkan hasil analisis statistik menggunakan ANOVA didapatkan hasil ekstrak etanol daun mahkota dewa dosis 0,75 g/kg BB mempunyai aktivitas analgesik mendekati asam mefenamat 500 mg. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-06-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/57 10.36490/journal-jps.com.v4i1.57 Journal of Pharmaceutical And Sciences; Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021); 12-20 2656-3088 10.36490/journal-jps.com.v4i1 eng https://www.journal-jps.com/index.php/jps/article/view/57/41 Copyright (c) 2021 Salman, Muharni Saputri, Ika Mustika http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/58 2021-10-04T12:12:55Z jps:ART driver

Antimicrobial Activity Jangjingki (Oxalis corniculata L.) Against The Growth Of Staphylococcus Aureus, Escherichia Coli, and Candida Albicans Aktivitas Antimikroba Jangjingki (Oxalis corniculata L.) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus, Escherichia coli Dan Jamur Candida albicans Misrahanum, Misrahanum Almunawwarah, Syarifah Dhea Helwati, Hira Maysarah, Hilda Sadli, Sadli Jangjingki (Oxalis corniculata L.) is a plant from Oxalidaceae that has potential as a natural antimicrobial agent. The purpose of this research is to see the antimicrobial activity of methanol extract of jangjingki against the growth of Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231. The thick extract of jangjingki was obtained by the maceration method with methanol solvent. At the same time, the antimicrobial activity test on S. aureus and E. Coli bacteria was carried out using the hole diffusion method. The simplicia characterization showed 7.17% water, 9.68% of total ash, 11.67% water-soluble extract, and 9.17% of the ethanol-soluble section. At the same time, the methanol extract of jangjingki characterization showed 22.5% of water, 10.16% of total ash, 55.83% water-soluble extract, and 62.91% of the ethanol-soluble section. Phytochemical test results showed that the methanol extract of jangjingki contains alkaloids, saponins, flavonoids, tannins, and steroids. The results of the antimicrobial activity test with variations in the concentration of jangjingki methanol extract 15, 20, 30, and 40% on S. aureus and E. Coli bacteria showed growth inhibition activity of these two bacteria, the largest diameter of the inhibition zone was formed when the extract was given a concentration of 40% with a diameter of the area. Resistance of 8,07 mm and 11 mm, respectively. Meanwhile, the test results of inhibition of growth of the fungus C. Albicans by presenting variations in the concentration of jangjingki methanol extract of 5, 10, 15, and 20% could not inhibit the growth fungus C. Albicans. Jangjingki (Oxalis corniculata L.) salah satu tumbuhan dari famili Oxalidaceae yang berpotensi sebagai antimikroba alami. Tujuan dari penelitian adalah untuk melihat aktivitas antimikroba ekstrak metanol jangjingki terhadap pertumbuhan bakteri Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, dan jamur Candida albicans ATCC 10231. Ekstrak diperoleh melalui metode maserasi dan uji aktivitas antimikroba dengan metode difusi sumuran. Hasil karakterisasi simplisia menunjukkan kadar air sebesar 7,17%, kadar abu total 9,68%, kadar sari larut air 11,67%, dan kadar sari larut etanol 9,17% Sementara karakterisasi ekstrak menunjukkan kadar air sebesar 22,5%, kadar abu total 10,16%, kadar sari larut air 55,83%, dan kadar sari larut etanol 62,91%. Uji fitokimia ekstrak jangjingki mengandung senyawa alkaloid, saponin, flavonoid, tanin, dan steroid. Hasil uji aktivitas antimikroba dengan variasi konsentrasi ekstrak metanol jangjingki 15, 20, 30 dan 40% pada  bakteri S. Aureus dan E. Coli menunjukkan aktifitas penghambatan pertumbuhan kedua bakteri tersebut, diameter zona hambat terbesar terbentuk pada pemberian ekstrak dengan konsentrasi 40% dengan diameter zona hambat berturut-turut sebesar 8,07 mm dan 11 mm. Sedangkan hasil uji aktifitas penghambatan pertumbuhan jamur C. Albicans dengan pemberian variasi konsentrasi ekstrak metanol jangjingki  sebesar 5, 10, 15, dan 20% tidak dapat menghambat pertumbuhan jamur C. albicans. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-06-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/58 10.36490/journal-jps.com.v4i1.58 Journal of Pharmaceutical And Sciences; Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021); 1-11 2656-3088 10.36490/journal-jps.com.v4i1 eng https://www.journal-jps.com/index.php/jps/article/view/58/40 Copyright (c) 2021 Misrahanum Misrahanum, Syarifah Dhea Almunawwarah, Hira Helwati, Hilda Maysarah, Sadli Sadli http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/60 2021-10-04T12:12:55Z jps:ART driver

Formulation and Evaluation of Edible Film dosage form herbal combination used potatoes starch (Solanum tuberosum L) as a polymer with variance of sorbitol as a plasticizers Formulasi Dan Evaluasi Sediaan Edible Film Strips Jus Herbal Kombinasi Menggunakan Polimer Pati Kentang (Solanum Tuberosum L) Dengan Variasi Plasticizer Sorbitol Wahyuni, Yenni Sri Rikmasari, Yopi Maulidiah, Rizka Edible film strips are a thin layer easily placed on the tongue or oral mucosal tissue, which will immediately get wet because the saliva will quickly disintegrate and dissolve. Combination herbal juice is used as an active substance made in edible film strips to increase the juice's shelf life. Edible film strips need polymers as a filmmaker, one of which is potato starch (Solanum tuberosum L). Edible film strips from starch have the disadvantage of tearing, so it needs a sorbitol plasticizer. Sorbitol concentration variations used were 0.4%, 0.7%, and 1%. This preparation was carried out with an organoleptic evaluation, friability, drying losses, pH, and disintegration. The research results on combined herbal juice edible film strips using variations in the sorbitol concentration as a plasticizer gave results that could be made into edible film strips, and potato starch could be used as a polymer in making edible film strips for combination herbal juices. Edible film strips merupakan lapisan tipis oral yang mudah saja diletakkan di lidah atau jaringan mukosa mulut yang akan langsung basah karena air liur kemudian akan cepat terdisintegrasi dan larut. Jus herbal kombinasi digunakan sebagai zat aktif yang dibuat menjadi  bentuk sediaan padatan untuk meningkatkan masa simpan dari jus. Edible film strips membutuhkan polimer pembentuk film salah satunya yaitu pati kentang (Solanum tuberosum L). Edible film strips dari pati mempunyai kelemahan mudah sobek sehingga perlu penambahan plasticizer yaitu sorbitol. Variasi konsentrasi sorbitol yang digunakan yaitu 0,4%, 0,7%, dan 1%. Dilakukan evaluasi organoleptis, kerapuhan, susut pengeringan, pH, dan disintegrasi. Hasil penelitian edible film strips jus herbal kombinasi menggunakan variasi konsentrasi sorbitol sebagai plasticizer memberikan hasil dapat dibuat menjadi sediaan edible film strips serta pati kentang dapat dijadikan polimer dalam pembuatan edible film strips jus herbal kombinasi Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/60 10.36490/journal-jps.com.v4i1.60 Journal of Pharmaceutical And Sciences; Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021); 21-28 2656-3088 10.36490/journal-jps.com.v4i1 eng https://www.journal-jps.com/index.php/jps/article/view/60/42 Copyright (c) 2021 Yenni Sri Wahyuni; Yopi Rikmasari; Rizka Maulidiah; http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/61 2021-10-04T12:12:55Z jps:ART driver

Use of Combination Therapy in Malaria Treatment and Prevention in Indonesia Penggunaan Terapi Kombinasi Dalam Pengobatan dan Pencegahan Malaria di Indonesia Trasia, Reqgi First Malaria is still a health problem in Indonesia. Treatment of malaria often encounters obstacles. Resistance to various malaria drugs in some areas causes an increase in morbidity and mortality due to malaria. Rational use of malaria drugs that are still effective and available is important. Therefore, this article will review the use of combination therapy in the treatment of malaria in Indonesia. The purpose of using combination therapy is to increase the efficacy of treatment and slow down the occurrence of resistance to each component in the drug. From this article, it can be concluded that artemisinin-based combinations using artemisinin derivatives are still effective for use as combination therapy against malaria. This combination can be a fixed combination or co-administered. The drugs that can be combined are 4-aminoquinoline, antifolate, 4-quinoline-methanol, artemisinin and its derivatives, antibiotics, and atovaquone-proguanil. It is hoped that the combination of these drugs can still be used for a long period of time, remain safe, effective and affordable by the community. Malaria masih menjadi masalah kesehatan di Indonesia. Pengobatan terhadap malaria kerap kali menemukan kendala. Resistensi terhadap berbagai obat malaria di beberapa daerah menyebabkan peningkatan angka morbiditas dan mortalitas akibat penyakit malaria. Penggunaan obat malaria secara rasional yang masih efektif dan tersedia merupakan hal yang penting. Untuk itu, artikel ini akan meninjau penggunaan terapi kombinasi dalam pengobatan malaria di Indonesia. Tujuan penggunaan terapi kombinasi adalah untuk meningkatkan efikasi pengobatan dan memperlambat terjadinya resistensi setiap komponen dalam obat tersebut. Dari artikel ini, dapat disimpulkan bahwa kombinasi berbasis artemisinin yang menggunakan derivat artemisinin masih efektif untuk digunakan sebagai terapi kombinasi terhadap malaria. Kombinasi ini dapat berupa fixed combination maupun co-administered. Adapun obat yang dapat dikombinasikan yaitu golongan 4-aminokuinolin, golongan obat antifolat, 4 quinoline-methanol, artemisinin dan derivatnya, antibiotik, serta atovakuon-proguanil. Kombinasi antara obat-obat tersebut diharapkan masih dapat digunakan dalam jangka waktu yang cukup lama, tetap aman, efektif dan terjangkau oleh masyarakat. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/61 10.36490/journal-jps.com.v4i1.61 Journal of Pharmaceutical And Sciences; Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021); 29-33 2656-3088 10.36490/journal-jps.com.v4i1 eng https://www.journal-jps.com/index.php/jps/article/view/61/43 Copyright (c) 2021 Reqgi First Trasia http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/62 2021-10-04T12:12:55Z jps:ART driver

FORMULATION AND EVALUATION OF BALM STICK FROM RED GINGER (Zingiber officinale rosc) OLEORESIN AS MUSCLE AND HINGE PAIN RELIEF FORMULASI DAN EVALUASI SEDIAAN BALSEM STIK DARI OLEORESIN JAHE MERAH (Zingiber officinale rosc) SEBAGAI PEREDA NYERI OTOT DAN SENDI Athaillah, Athaillah Lianda, Sinta Okta Ginger develops rapidly and is widely used with appropriate processing systems. The main chemical compounds found in ginger are essential oils, oleoresin and starch. Extraction of oleoresin from ginger rhizome is increasingly being used as a raw material for medicine. This study aims to extract oleoresin from ginger and use it as a stick balm preparation. The extraction process was carried out at a temperature of 40◦c for 3 hours using 96% ethanol solvent with a ratio of 1: 5, namely ginger powder with a size of ± 40 mesh as much as 300 grams with 1500 ml solvent. The extraction results were separated using a rotary vacuum evaporator to obtain oleoresin. The result of standarization of red ginger simplicia powder meet the requirements. The result of the four formulas show that the stick balm meets the requirements for the evaluation of the stick balm preparation. Formula 3 with 10% (w/v) red ginger extract was chosen as the best formula because it produces a better warm taste. Jahe berkembang secara cepat dan pemanfaatan yang luas dengan sistem pengolahan  tepat guna. Kandungan senyawa kimia utama yang terdapat pada jahe adalah minyak atsiri, oleoresin dan pati. Ekstraksi oleoresin dari rimpang jahe semakin banyak dimanfaatkan sebagai bahan baku pembuatan obat. Penelitian ini bertujuan melakukan ekstraksi oleoresin dari jahe dan dimanfaatkan sebagai sediaan balsem stik. Proses ekstraksi dilakukan pada suhu 40◦c dengan waktu 3 jam menggunakan pelarut etanol 96% dengan perbandingan 1 : 5 yaitu serbuk jahe dengan ukuran ± 40 mesh sebanyak 300 gram dengan pelarut 1500 ml. Hasil ekstraksi dipisahkan menggunakan rotary vakum evaporator sehingga diperoleh ekstrak kental oleoresin. Hasil standarisasi serbuk simplisia jahe merah memenuhi persyaratan yang telah ditetapkan. Hasil dari ke 4 formula menunjukan bahwa balsem stik memenuhi persyaratan evaluasi sediaan balsem stik. Formula 3 dengan 10 %(b/v) ekstrak jahe merah dipilih sebagai formula terbaik karena menghasilkan rasa hangat yang lebih bagus. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/62 10.36490/journal-jps.com.v4i1.62 Journal of Pharmaceutical And Sciences; Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021); 34-40 2656-3088 10.36490/journal-jps.com.v4i1 ind https://www.journal-jps.com/index.php/jps/article/view/62/44 Copyright (c) 2021 Athaillah; Sinta Okta Lianda http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/64 2022-04-19T16:46:51Z jps:ART driver

THE EFFECT GIVING OF DUTCH TEAK LEAF KOMBUCHA TEA (Guazuma ulmifolia Lamk) AGAINST REDUCTION BLOOD TRIGLYCERIDE LEVELS OF WHITE RATS MALE (Rattus norvegicus) PENGARUH PEMBERIAN TEH KOMBUCHA DAUN JATI BELANDA (Guazuma ulmifolia Lamk ) TERHADAP PENURUNANAN KADAR TRIGLISERIDA DARAH TIKUS PUTIH JANTAN (Rattus norvegicus) Lubis, Salmah Handayani Saputri, Muharni Hasanah, Nikmatul Indriana, Meutia Kombucha tea is high in antioxidants and can help reduce triglyceride levels by increasing the lipoprotein lipase enzyme activity to break down triglycerides. Previous studies have shown that giving Guazuna ulmifolia can reduce blood lipid levels because the content of tannins and mucilage can reduce fat absorption. This study aimed to determine the effect of giving kombucha tea leaves of Dutch teak to reduce blood triglyceride (TGD) levels of white male rats. This research method is experimental, including material collection, simplicia, phytochemical screening, kombucha fermentation of Dutch teak leaves, evaluating the quality of the preparation, testing triglyceride levels in rats with Electrode Based Biosensor technique. A total of 25 rats were divided into five groups; there is simvastatin its positive control (P1); negative control its blank (P2); the treatment group for teak kombucha tea leaves are 100 ml consecutively (P3); 150ml (P4); 200 ml (P5) induced using 80% egg yolk and 0.2% propiniltiourasil (PTU). This research method is experimental, including material collection, making simplicia, phytochemical screening, kombucha fermentation of Dutch teak leaves, evaluation of the quality of preparations, testing of triglyceride levels in rats with Electrode-Based Biosensor technique. This study was divided into 5 (five) groups, namely: P1; P2; P3, P4 and P5, administered orally to 25 rats that had been induced using 80% egg yolk and propinylthiouracil (PTU 0.2%). This study was divided into 5 groups, namely positive control simvastatin 0.025% given 1.44 ml (P1); negative control its (blank) was given as much as 3.6 ml (P2); Dutch teak leaf kombucha tea treatment group was given 100 ml/gBW in a row as much as 1.8 ml (P3); 150 ml/gBW was given as much as 2.7 ml (P4); 200 ml/gBW was given as much as 3.6 ml (P5).The results showed that in the 200 ml treatment group (P5) on day 7 to day 15, there was a decrease in TGD levels from 246.8 mg/dL to 93 ml/dL where this result was close to the positive control number (P1) of 238.6 mg/dL to 84 mg/dL. The results of the Kruskal-Wallis statistical test were p=0.98 (p>0.05), meaning that there was no significant difference between the test groups on the triglyceride levels obtained. The results showed that in the 200 ml treatment group (P5) on day 7 to day 15, there was a decrease in the TGD levels from 246.8 mg/dL to 93 ml/dL with the percentage reduction in triglycerides obtained by 37.68%, where these results close to the positive control number (P1) from 238.6 mg/dL to 84 mg/dL with the percentage reduction in triglycerides obtained by 35.20%. In testing triglyceride levels in the experimental group, different results were obtained in each experimental group The results of testing the triglyceride levels obtained, then carried out statistical tests in the form of non-parametric using the Khurskal Wallis method, from the test results obtained p = 0.098 (p = 0.05) which indicates that the data is normally distributed Teh kombucha merupakan tinggi antioksidan dan mampu membantu menurunkan kadar trigliserida dengan cara meningkatkan aktivitas enzim lipoprotein lipase yang dapat bekerja memecah trigliserida. Studi sebelumnya mengatakan bahwa daun jati belanda (Guazuma ukmifolia, Lamrk) mampu menurunkan kadar lipid darah karena kandungan tanin dan mucilago yang mampu mengurangi absorpsi lemak. Tujuan Penelitian ini untuk mengetahui efek pemberian teh kombucha daun jati belanda mampu menurunkan angka trigliserida (TGD) darah tikus putih jantan. Metode penelitian ini berupa eksperimental meliputi pengumpulan bahan, pembuatan simplisia, skrining fitokimia, fermentasi kombucha daun jati belanda, evaluasi mutu sediaan, pengujian kadar trigliserida pada tikus dengan teknik Elektrode-Based Biosensor. Penelitian ini dibagi menjadi 5 (lima) kelompok yaitu: P1; P2; P3, P4 dan P5, pemberian obat dan  dilakukan secara oral kepada 25 ekor tikus yang telah diinduksi menggunakan kuning telur 80% dan propiniltiourasil (PTU 0,2%). Penelitian ini dibagi menjadi 5 kelompok yaitu kontrol positif simvastatin 0,025% diberikan sebanyak 1,44 ml  (P1); kontrol negatif  kombucha tanpa sampel (blanko) diberikan sebanyak 3,6 ml  (P2); kelompok perlakuan teh kombucha daun jati belanda berturut-turut 100 ml/gBB diberikan sebanyak 1,8 ml (P3); 150 ml/gBB diberikan sebanyak 2,7 ml (P4); 200 ml/gBB diberikan sebanyak 3,6 ml (P5). Hasil penelitian menunjukkan pada kelompok perlakuan 200 ml (P5) pada hari ke-7 sampai hari ke-15 terjadi penurunan angka TGD dari 246,8 mg/dL menjadi 93 ml/dL dengan persentase penurunan trigliserida diperoleh 37,68%, dimana hasil ini mendekati angka kontrol positif (P1) dari 238,6 mg/dL menjadi 84 mg/dL dengan persentase penurunan trigliserida diperoleh 35,20%. Pada pengujian kadar trigliserida pada kelompok percobaan, didapatkan hasil yang berbeda pada tiap kelompok percobaan. Hasil pengujian kadar trigliserida yang di dapatkan, selanjutnya dilakukan uji statistika berupa non parametrik dengan menggunakan metode khurskal wallis, dari hasil pengujian didapatkan hasil p=0.098 (p=0,05) yang menunjukan bahwa data terdistribusi secara normal Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-09-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/64 10.36490/journal-jps.com.v4i2.64 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 41-52 2656-3088 10.36490/journal-jps.com.v4i2 ind https://www.journal-jps.com/index.php/jps/article/view/64/45 Copyright (c) 2021 Salmah Handayani Lubis, Muharni Saputri, Nikmatul Hasanah http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/65 2022-03-14T11:06:09Z jps:ART driver

Drug of Choice in The Treatment of Protozoa Infection in Indonesia Pilihan Obat Dalam Tata Laksana Infeksi Protozoa di Indonesia Trasia, Reqgi First Protozoal infections are still reported to be widespread in several regions around the world, especially in areas with subtropical and tropical climates, where the environment is poor in hygiene. This disease is endemic in several areas in Indonesia, both on the island of Java and outside, especially in rural areas. So far, the treatment of protozoal infections still relies on nitroimidazole antibiotics. However, there are a number of reports of resistance and treatment failure with these antibiotics. In Indonesia, there are still few articles that discuss the treatment of parasitic infections. The purpose of writing this article is to review the therapeutic options that can be used in the management of protozoal infections in Indonesia. From this review, it can be concluded that in addition to the nitroimidazole group, clefamide, amphotericin-B, oxytetracycline, trimetoprim-sulfametoxazole, paramomycin, and nitazoxanide can also be used as alternative treatments. Infeksi protozoa masih dilaporkan tersebar luas di beberapa wilayah di seluruh dunia, khususnya di area dengan iklim subtropis dan tropis, dimana lingkungannya memiliki higienitas yang buruk. Penyakit ini menjadi endemi di beberapa daerah di Indonesia, baik di pulau Jawa maupun di luar, terutama di area pedesaan. Pengobatan infeksi protozoa sejauh ini masih mengandalkan antibiotik golongan nitroimidazole. Meski demikian, terdapat sejumlah laporan mengenai resistensi dan kegagalan pengobatan dengan antibiotik tersebut. Di Indonesia, masih sedikit artikel yang membahas mengenai pengobatan infeksi parasit. Tujuan dari penulisan artikel ini adalah untuk meninjau pilihan terapi yang dapat digunakan dalam tata laksana infeksi protozoa di Indonesia. Dari tinjauan tersebut, dapat disimpulkan bahwa selain golongan nitroimidazole, dapat pula clefamide, amfoterisin-B, oksitetrasiklin, trimetoprim-sulfametoxazole, paramomycin, dan nitazoxanide dijadikan sebagai alternatif pengobatan. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/65 10.36490/journal-jps.com.v4i2.65 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 101-104 2656-3088 10.36490/journal-jps.com.v4i2 eng https://www.journal-jps.com/index.php/jps/article/view/65/63 Copyright (c) 2021 Reqgi First Trasia http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/66 2022-03-14T11:06:09Z jps:ART driver

Study of Secondary Metabolites in Jeruk Sambal Juice (Citrus microcarpa Bunge) From Desa Kalimas, Kalimantan Barat Kajian Metabolit Sekunder dalam Air Perasan Jeruk Sambal (Citrus microcarpa Bunge) yang Berasal dari Desa Kalimas, Kalimantan Barat Yanti, R. S. A, Syarifah Nurul Chandra, Veren Evelyn -, Vanesa - Jeruk sambal (Citrus microcarpa Bunge) is a plant that is widely known by the people of Kalimantan Barat which has the potential to contain various secondary metabolites. The purpose of this study was to determine the content of secondary metabolites contained in the juice of Jeruk sambal from Desa Kalimas, Kalimantan Barat. The study began with making Jeruk sambal juice by washing the Jeruk sambal fruit under running water and drying it. Then the Jeruk sambal fruit was cut into two parts, squeezed manually using sterile gloves, and filtered twice using a plastic filter and sterile filter paper into a glass bottle. Phytochemical screening of Jeruk sambal juice was carried out qualitatively. The results of phytochemical screening showed that Jeruk sambal juice contains alkaloids, flavonoids, saponins, tannins, and saponins. The highest secondary metabolite content in Jeruk sambal juice is saponins (+++). Meanwhile, the test of steroids and terpenoids was found to be negative. The conclusion is that Jeruk sambal juice contains alkaloids, flavonoids, saponins, tannins, and saponins. Jeruk sambal (Citrus microcarpa Bunge) merupakan tanaman yang dikenal luas oleh masyarakat Kalimantan Barat yang berpotensi mengandung berbagai senyawa metabolit sekunder. Tujuan dari penelitian ini adalah mengkaji kandung senyawa metabolit sekunder yang terkandung dalam air perasan buah jeruk sambal dari Desa Kalimas, Kalimantan Barat. Penelitian diawali dengan pembuatan air perasan jeruk sambal dilakukan dengan mencuci buah jeruk sambal dibawah air mengalir dan dikeringkan. Kemudian buah jeruk sambal dipotong menjadi dua bagian, diperas secara manual menggunakan tangan yang telah memakai sarung tangan steril, dan disaring sebanyak dua kali menggunakan penyaring plastik serta kertas saring steril ke dalam botol kaca. Skrining fitokimia air perasan jeruk sambal dilakukan secara kualitatif. Hasil skrining fitokimia menunjukkan air perasan jeruk sambal mengandung alkaloid, flavonoid, saponin, tanin, dan saponin Kandungan metabolit sekunder terbanyak pada air perasan jeruk sambal adalah saponin (+++). Sedangkan pengujian steroid dan terpenoid didapati hasil negatif. Kesimpulan dari penelitian ini bahwa air perasan jeruk sambal mengandung alkaloid, flavonoid, saponin, tanin, dan saponin. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/66 10.36490/journal-jps.com.v4i2.66 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 105-110 2656-3088 10.36490/journal-jps.com.v4i2 ind https://www.journal-jps.com/index.php/jps/article/view/66/64 Copyright (c) 2021 Syarifah Nurul Yanti, R. S. A, Veren Evelyn Chandra, Vanesa - - http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/67 2022-03-08T18:06:33Z jps:ART driver

Analysis of the Presence of Aedes Aegypti Larvae and Eradication of Mosquito Nests on Percut Urban Village, Percut Sei Tuan Subdistrict, Deli Serdang District in 2021 Analisis Keberadaan Larva Nyamuk Aedes Aegypti dan Pemberantasan Sarang Nyamuk di Kelurahan Percut Kecamatan Percut Sei Tuan Kabupaten Deli Serdang Tahun 2021 Hutasuhut, Vina Anggina Percut Sei Tuan is district with the highest incidence of dengue fever in Deli Serdang Regency in 2020. The environment has an important role as the causes of the dengue hemorrhagic fever (WHO, 2009). This study was conducted the efforts to prevent dengue fever through the presence of larvae  in water containers and efforts to eradicate mosquito nests on percut urban village, subdistrict of percut. This research is descriptive. The research sample was 109 respondents with simple random sampling. Through the results of this study, it was found that larvae were found in 88 respondents' houses. the mosquito nest eradication considered that not actively implemented. recommended in next study to research correlation  implementation of mosquito nest eradication and the presence of larvae Percut sei tuan merupakan kecamatan dengan kejadian demam berdarah tertinggi di kabupaten Deli serdang pada tahun 2020. Lingkungan memiliki peranan penting sebagai faktor yang menyebabkan kejadian demam berdarah (WHO, 2009). Penelitian ini dilakukan dengan tujuan mengetahui upaya pencegahan demam berdarah melalui keberadaan larva jentik pada kontainer air dan upaya pemberantasan sarang nyamuk di kelurahan percut kecamatan percut sei tuan. Penelitian ini berjenis deskriptif. Sampel penelitian sebanyak 109 responden yang diambil berdasarkan teknik simple random sampling. Melalui hasil penelitian ini diketahui ditemukan larva jentik di 88 rumah responden. Untuk pelaksanaan pemberantasan sarang nyamuk dinilai belum dilaksanakan dengan aktif oleh responden. Disarankan kepada responden untuk menggalakkan kegiatan pemberantasan sarang nyamuk secara rutin. Pada penelitian berikutnya disarankan melihat korelasi pelaksanaan pemberantasan sarang nyamuk dan keberadaan larva jentik. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-12-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/67 10.36490/journal-jps.com.v4i2.67 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 53-55 2656-3088 10.36490/journal-jps.com.v4i2 ind https://www.journal-jps.com/index.php/jps/article/view/67/47 Copyright (c) 2021 Vina Anggina Hutasuhut http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/68 2022-08-09T23:16:02Z jps:ART driver

Appropriateness Analysis of Scabies Treatment toward Clinical Practice Guideline (CPG) in Songgon Public Health Center, Banyuwangi The Analisis Kesesuaian Terapi Skabies terhadap Panduan Praktik Klinis (PPK) di Puskesmas Songgon, Banyuwangi Budi Utami, Vika Habsari Wulan, I Gusti Ayu Kencana Introduction: Scabies is an infectious ectoparasitic disease that is still a public health problem in Indonesia. There are differences in the pattern of prescribing or therapy in various health facilities. .Aim of study: Knowing the suitability of scabies therapy against the Clinical Practice Guidelines (PPK) at the Songgon Health Center, Banyuwangi. Method: This study uses a descriptive analysis design with a retrospective study. This study looked at the medical record data of random patients with a diagnosis of scabies from February to May 2021 at the Songgon Health Center, Banyuwangi. Results and Discussions: Overall, there were 7 treatments given to patients with a diagnosis of scabies, which corresponded to PPK only 2 types of drugs (28%), with deviations from PPK, namely 5 types of drugs (72%). It was found that 22 respondents (56%) received 2-4 ointment therapy, 16 respondents (41%) received 5% permethrine therapy, 1 respondent (3%) did not receive definitive line therapy for scabies. The rate of non-adherence to therapy is 3% related to definitive treatment of scabies. Conclusions:  Scabies therapy at the Songgon Health Center, Banyuwangi has not been in accordance with the Clinical Practice Guidelines (CPG). Latar Belakang: Skabies merupakan penyakit infeksi ektoparasit menular yang masih menjadi masalah kesehatan masyarakat di Indonesia. Terdapat perbedaan pola peresepan atau terapi di berbagai fasilitas kesehatan. Tujuan Penelitian: Mengetahui kesesuaian terapi skabies terhadap Panduan Praktik Klinis (PPK) di Puskesmas Songgon, Banyuwangi. Metode: Penelitian ini menggunakan desain analisis deskriptif dengan studi retrospektif. Penelitian ini melihat data rekam medik pasien secara acak dengan diagnosis skabies dari bulan Februari sampai Mei 2021 di Puskesmas Songgon, Banyuwangi. Hasil Penelitian: Secara keseluruhan, terdapat 7 terapi yang diberikan pada pasien dengan diagnosis skabies, yang sesuai dengan PPK hanya 2 jenis obat (28%), dengan penyimpangan dari PPK yaitu 5 jenis obat (72%). Didapatkan 22 responden (56%) mendapatkan terapi salep 2-4, 16 responden (41%) mendapatkan terapi permethrine 5%, 1 responden (3%) tidak mendapatkan terapi lini definitif untuk skabies. Angka ketidaksesuaian terapi sebesar 3% terkait terapi definitif skabies. Kesimpulan: Terapi skabies di Puskesmas Songgon, Banyuwangi belum sesuai dengan Panduan Praktik Klinis (PPK). Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/68 10.36490/journal-jps.com.v5i1.68 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 101-107 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/68/75 Copyright (c) 2022 Vika Habsari Budi Utami, I Gusti Ayu Kencana Wulan http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/71 2022-08-09T23:16:02Z jps:ART driver

OTOTOXICITY IN MULTIDRUG-RESISTANT TUBERCULOSIS: A SCOPING REVIEW OF THE INDONESIAN STUDIES OTOTOKSISITAS PADA PASIEN TUBERKULOSIS RESISTEN OBAT: SCOPING REVIEW PADA STUDI DI INDONESIA Putra, Oki Nugraha N.H., Affan Yuniar Hidayat, Fariz Sagitha, I.G.E. A wide variation in ototoxicity or hearing loss due to injectable anti-tubercular drugs in patients with multidrug-resistant tuberculosis (MDR-TB) has been reported globally and in Indonesia. This scoping review assesses the ototoxicity of second-line injectable anti-tubercular drugs in Indonesian patients with MDR-TB. This review was conducted under the recommended PRISMA extension for scoping review (PRISMA-ScR). The Google Scholar and PubMed database were used to search the articles on MDR-TB in the Indonesian population. Seven studies were identified based on the inclusion criteria reporting kanamycin and capreomycin in the management of MDR-TB. Ototoxicity was observed in 39.3% (116/295) MDR-TB patients. Ototoxicity was observed in kanamycin, 38.7% (105/271 patients); capreomycin, 36,8% (7/19 patients); and kanamycin plus capreomycin, 80% (4/5 patients).  Only one study reported risk factors ototoxicity in MDR-TB patients. Ototoxicity was significantly associated with older age and the length of kanamycin therapy correlates with hearing loss. This review identified a high prevalence of ototoxicity in Indonesian patients with MDR-TB treated with second-line injectable drugs. Efforts were urgently needed to develop guidelines for monitoring ototoxicity, improving pharmacist and clinician awareness, and educating patients or caregivers to report hearing loss symptoms as a sign of ototoxicity.   Keywords: MDR-TB; Ototoxicity, Second-line injectable     Variasi yang luas dalam ototoksisitas atau gangguan pendengaran akibat obat antituberkulosis injeksi pada pasien dengan multidrug-resistant tuberculosis (MDR-TB) telah dilaporkan secara global dan di Indonesia. Scoping review ini mengulas ototoksisitas obat antituberkulosis injeksi lini kedua pada pasien MDR-TB di Indonesia. Tinjauan ini dilakukan menggunakan PRISMA extension for scoping review (PRISMA-ScR). Database Google Scholar dan PubMed digunakan untuk mencari artikel tentang MDR-TB pada penelitian di Indonesia. Tujuh penelitian diidentifikasi berdasarkan kriteria inklusi yang melaporkan kanamisin dan kapreomisin sebagai tatalaksana MDR-TB. Ototoksisitas ditemukan pada 39,3% (116/295) pasien TB-MDR. Ototoksisitas diamati pada kanamisin, 38,7% (105/271 pasien); kapreomisin, 36,8% (7/19 pasien); dan kanamisin ditambah kapreomisin, 80% (4/5 pasien). Hanya satu penelitian yang melaporkan faktor risiko ototoksisitas pada pasien TB-MDR. Ototoksisitas secara signifikan terkait dengan usia yang lebih tua dan lamanya terapi kanamisin berkorelasi dengan gangguan pendengaran. Review ini mengidentifikasi prevalensi tinggi ototoksisitas pada pasien MDR-TB Indonesia yang diobati dengan obat injeksi lini kedua. Upaya sangat diperlukan untuk mengembangkan pedoman untuk memantau ototoksisitas, meningkatkan kesadaran apoteker dan dokter, dan mendidik pasien untuk melaporkan gejala gangguan pendengaran sebagai tanda ototoksisitas. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/71 10.36490/journal-jps.com.v5i1.71 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 62-73 2656-3088 10.36490/journal-jps.com.v5i1 eng https://www.journal-jps.com/index.php/jps/article/view/71/70 Copyright (c) 2022 Oki Nugraha Putra; Affan Yuniar.N.H; Fariz Hidayat; I.G.E. Sagitha; http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/73 2022-08-09T23:16:02Z jps:ART driver

Evaluation of Anti-acne Gel Preparations Combination of Aloe Vera Leaf Extract (Aloe vera (L) Brum F.) And Betel Leaf Extract (Piper betle L.) Evaluasi Sediaan Gel Antijerawat Kombinasi Ekstrak Daun Lidah Buaya (Aloe vera (L) Brum F.) Dan Ekstrak Daun Sirih (Piper betle L.) Ginting, Ovalina Sylvia Br. Rahmah, Putri The use of natural ingredients as herbal medicines has been widely carried out by the community today. Besides being able to save costs, if it can be made easily and cheaply and people believe it has fewer side effects and savety. Aloe vera (Aloe vera (L) Burm.F.) and betel leaf (Piper betle L.) are popular and easy to obtain plants. This plant contains secondary metabolites in the form of flavonoids, tannins, saponins and alkaloids. Secondary metabolite compounds contained in aloe vera and betel leaf can help the occurrence of infections by various skin bacteria that cause itching and acne. To overcome one of the main problems of facial skin, namely acne, the most suitable and effective dosage form to use is gel preparation. In this study, a gel formulation was carried out with 5 formulas. Which is based on differences in the concentration of the active substance of aloe vera extract and betel leaf extract. This research was conducted experimentally and aims to determine the effect of variations in the concentration of the active substance on the physical and chemical stability of the preparation. The extraction process was carried out by maceration using 80% ethanol. The evaluations carried out included: organoleptic tests, pH tests, homogeneity tests and tests for the spreadability of gel preparations for 21 days. The results showed that the best formula was formula 2. This proves that changes in temperature and storage duration can affect the quality of the gel so that it can affect the physical and chemical properties of the gel produced. Pemanfaatan bahan alam sebagai obat-obat herbal telah banyak dilakukan oleh masyarakat saat ini. Selain dapat menghemat biaya, jika dapat dibuat dengan mudah dan murah serta dipercaya masyarakat memiliki efek samping yang lebih kecil dan lebih aman. Tanaman lidah buaya (Aloe vera (L) Burm.F.) dan daun sirih (Piper betle L.) merupakan salah satu tanaman yang populer dan mudah untuk di dapat. Tanaman ini memiliki kandungan metabolit sekunder berupa flavonoid, tanin, saponin dan alkaloid. Senyawa metabolit sekunder yang terkandung dalam tanaman lidah buaya dan daun sirih dapat membantu terjadinya infeksi oleh berbagai bakteri kulit penyebab gatal dan juga jerawat. Untuk mengatasi salah satu masalah utama kulit wajah yaitu timbulnya jerawat, maka bentuk sediaan yang paling sesuai dan efektif untuk digunakan adalah sediaan gel. Pada penelitian ini adakan dilakukan formulasi sediaan gel dengan 5 formula. Yang didasarkan pada perbedaan konsentrasi zat aktif ekstrak lidah buaya dan ekstrak daun sirih. Penelitian ini dilakukan secara eksperimental dan bertujuan untuk mengetahui pengaruh variasi konsentrasi zat aktif terhadap stabilitas fisika dan kimia sediaan. Proses pembuatan ekstrak dilakukan secara maserasi menggunakan etanol 80%. Evaluasi yang dilakukan antara lain: uji organoleptis, uji pH, uji homogenitas dan uji daya sebar sediaan gel selama 21 hari. Hasil penelitian menunjukkan bahwa formula yang terbaik adalah formula 2. Hal ini membuktikan bahwa perubahan suhu dan lamanya penyimpanan dapat mempengaruhi kualitas gel sehingga dapat mempengaruhi sifat fisika dan kimia gel yang dihasilkan. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-04-19 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/73 10.36490/journal-jps.com.v5i1.73 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 12-20 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/73/66 Copyright (c) 2022 Ovalina Sylvia Br. Ginting, Putri Rahmah http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/74 2022-03-08T18:06:33Z jps:ART driver

ANTIBACTERIAL ACTIVITY OF RESIDUE FRACTION FROM ETHANOL EXTRACT OF BAWANG SABRANG (Eleutherine palmifolia Merr.) BULBS AKTIVITAS ANTIBAKTERI FRAKSI SISA DARI EKSTRAK ETANOL UMBI BAWANG SABRANG (Eleutherine palmifolia Merr.) Mierza, Vriezka Nasution, M. Pandapotan Suryanto, Dwi Bacterial resistance to antibiotics causes the death rate to increase. In dealing with this problem, studies were carried out, one of which was by utilizing natural medicinal ingredients such as bawang sabrang (Eleutherine palmifolia Merr.) of the Iridaceae family. This study aims to determine the antibacterial activity of the residual fraction of the ethanolic extract of bawang sabrang bulbs (Eleutherine palmifolia Merr.) against gram-positive and gram-negative bacteria and to determine the class of chemical compounds. Extraction was carried out by maceration using ethanol as a solvent and continued by successive fractionation using n-hexane and ethylacetate solvents, so that the remaining fraction was obtained. Antibacterial activity testing was carried out in vitro using the agar diffusion method using metal rings at concentrations of 20 mg/ml, 10 mg/ml and 5 mg/ml against gram-positive bacteria (Bacillus pumilus ATCC 7061, Bacillus subtilis ATCC 6633, Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 25923, Micrococcus luteus ATCC 9341, Propionibacterium acne ATCC 6918, Staphylococcus aureus ATCC 29737, Staphylococcus epidermidis ATCC 12228) and gram-negative bacteria (Klebsiella pneumoniae ATCC 10031, Escherichia coli ATCC 10536, Salmonella thypi ATCC 29213). The analysis of the chemical compound group of the residual fraction was carried out using a phytochemical screening technique. The residual fraction of the ethanolic extract of bawang sabrang bulbs had antibacterial activity on all the tested bacteria. The chemical compounds contained in the remaining fraction of the ethanolic extract of bawang sabrang bulbs are alkaloids, flavonoids, glycosides, saponins, anthraquinone glycosides, tannins, triterpenoids, and steroids. Kekebalan bakteri terhadap antibiotik menyebabkan angka kematian semakin meningkat. Dalam menghadapi masalah tersebut, dilakukan penelitian-penelitian, salah satunya dengan memanfaatkan bahan-bahan obat alam seperti umbi bawang sabrang (Eleutherine palmifolia Merr.) famili Iridaceae. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri fraksi sisa dari ekstrak etanol umbi bawang sabrang (Eleutherine palmifolia Merr.) terhadap bakteri gram positif dan bakteri gram negatif serta mengetahui golongan senyawa kimianya. Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut etanol dan dilanjutkan dengan fraksinasi secara berturut-turut menggunakan pelarut n-heksan dan etilasetat, sehingga diperoleh fraksi sisa. Pengujian aktivitas antibakteri dilakukan secara in vitro dengan metode difusi agar menggunakan pencadang logam pada konsentrasi 20 mg/ml, 10 mg/ml dan 5 mg/ml terhadap bakteri gram positif (Bacillus pumilus ATCC 7061, Bacillus subtilis ATCC 6633, Methicillin-resistant Staphylococcus aureus (MRSA) ATCC 25923, Micrococcus luteus ATCC 9341, Propionibacterium acne ATCC 6918, Staphylococcus aureus ATCC 29737, Staphylococcus epidermidis ATCC 12228) dan bakteri gram negatif (Klebsiella pneumoniae ATCC 10031, Escherichia coli ATCC 10536, Salmonella thypi ATCC 29213). Analisis golongan senyawa kimia fraksi sisa dilakukan dengan teknik skrining fitokimia. Fraksi sisa dari ekstrak etanol umbi bawang sabrang memiliki aktivitas antibakteri pada seluruh bakteri uji. Golongan senyawa kimia yang terdapat pada fraksi sisa ekstrak etanol umbi bawang sabrang adalah alkaloid, flavonoid, glikosida, saponin, antrakuinon glikosida, tanin, triterpenoid, steroid. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-12-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/74 10.36490/journal-jps.com.v4i2.74 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 60-68 2656-3088 10.36490/journal-jps.com.v4i2 ind https://www.journal-jps.com/index.php/jps/article/view/74/48 Copyright (c) 2021 Vriezka Mierza http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/75 2022-03-09T15:09:07Z jps:ART driver

ANTI-BACTERIAL ACTIVITY OF ETHANOL EXTRACT FROM THE FLOWER OF KECOMBRANG (Etlingera elatior Jack.) IN VITRO AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DARI BUNGA TUMBUHAN KECOMBRANG (Etlingera elatior Jack.) SECARA IN VITRO salman, salman Indriana, Meutia Traditionally, kecombrang flowers have been used to treat various diseases, including colds, earaches, blood purifiers, treat festering wounds and eliminate body odor. Various bacteria may cause ear diseases, purulent wounds, and body odor, so the kecombrang flower, which has been used traditionally to treat this disease, maybe due to its anti-bacterial activity against both Gram-positive and Gram-negative, so it is necessary to do research with the aim of ensuring the presence of anti-bacterial activity. This research includes collecting kecombrang flowers, plant identification, making Simplicia, phytochemicals, making kecombrang flower extracts by percolation with 96% ethanol extract. Testing anti-bacterial activity in vitro by diffusion method with punch holes on Mueller Hinton Agar medium, and used Ampicillin sulfate 20 g/ml as a control against Staphylococcus aureus, Streptococcus pneumonia, Escherichia coli, and Pseudomonas aeruginosa bacteria. Phytochemical screening showed the presence of the same group of compounds, namely alkaloids, flavonoids, steroids, glycosides, and essential oils. The results of the anti-bacterial activity test of the ethanol extract of the excellent kecombrang flower against Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, and less suitable for Pseudomonas aeruginosa. Secara tradisional bunga kecombrang telah digunakan untuk mengobati berbagai penyakit, di antaranya masuk angin, sakit telinga, pembersih darah, mengobati luka yang bernanah dan menghilangkan bau badan. Penyakit telinga, luka bernanah dan bau badan ada kemungkinan disebabkan oleh berbagai bakteri, sehingga ada kemungkinan bunga kecombrang yang telah digunakan secara tradisional untuk mengobati penyakit ini dikarenakan mempunyai aktivitas sebagai anti bakteri balk terhadap Gram positif maupun Gram negatif, sehingga perlu dilakukan penelitian dengan tujuan untuk memastikan adanya aktivitas sebagai antibakteri. Penelitian ini meliputi pengumpulan bunga kecombrang, identifikasi tumbuhan, pembuatan simplisia, fitokimia, pembuatan ekstrak bunga kecombrang secara perkolasi dengan penyari etanol 96%, dan pengujian aktivitas antibakteri secara in vitro dengan metode difusi dengan cetak lubang (punch hole) pada medium Mueller Hinton Agar, clan digunakan Ampisilin sulfat 20 µg/ml sebagai kontrol terhadap bakteri Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli dan Pseudomonas aeruginosa. Skrining fitokimia menunjukkan adanya golongan senyawa yang sama yaitu alkaloid, flavonoida, steroida, glikosida dan minyak atsiri. Hasil uji aktivitas antibakteri ekstrak etanol bunga kecombrang yang sangat balk terhadap bakteri Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, dan kurang balk terhadap bakteri Pseudomonas aeruginosa. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-12-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/75 10.36490/journal-jps.com.v4i2.75 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 69-73 2656-3088 10.36490/journal-jps.com.v4i2 eng https://www.journal-jps.com/index.php/jps/article/view/75/49 Copyright (c) 2021 salman salman, Meutia Indriana http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/76 2022-03-14T10:44:09Z jps:ART driver

THE USE OF KESUMBA (Bixa orellana L.) FRUIT EXTRACT AS LIPSTICK COLORS PENGGUNAAN EKSTRAK BIJI BUAH KESUMBA (Bixa orellana L.) SEBAGAI PEWARNA LIPSTIK Indriana, Meutia salman, salman Recently, there have been hundreds of lip color cosmetics on the market in various colors. However, not all lip colors are safe to use. Without realizing it, there are lip dyes that contain dyes that are dangerous and are prohibited because they can cause irritation to the skin and respiratory tract. Therefore, it is better to use natural dyes. One of the sources of natural dyes is the fruit of kesumba. Extracts from simplicia of kesumba seeds were made by percolation using 96% ethanol as a solvent. The lipstick formulation formula consists of Cera alba, vaseline alba, lanolin, carnauba wax, cetyl alcohol, oleum ricini, propylene glycol, titanium dioxide, butylhydroxytoluene, tween 80, rose oil (oleum rosae), and nipagin, as well as the addition of kesumba seed extract with concentrations of 15%, 17.5%, 20%, 22.5%, and 25%. Tests on the preparations made included examination of the melting point, homogeneity, lipstick strength, stability test against changes in shape, color, and odor during 30 days of storage at room temperature, smear test, and pH examination, and irritation test preference test (Hedonic test). The results of the research that the extract of the kesumba fruit seed can be formulated in lipstick preparations with a light yellow to dark maroon color. The formulation of the kesumba seed extract in the lipstick preparation shows that the preparation is relatively stable homogeneous, the melting point is 58°C, has a good lipstick strength, the pH ranges from 6.3 to 5.7 (according to the pH of the skin) easy to apply with an even color. , does not irritate, so it is safe to use; the pretty preferred preparations are preparations 2, 3, and 4, namely the formula with extracts of kesumba seeds with concentrations of 17.5%, 20%, and 22.5%. Akhir-akhir ini terdapat ratusan kosmetik pewarna bibir yang beredar di pasaran dengan berbagai jenis warna. Akan tetapi, tidak semua pewarna bibir tersebut aman untuk digunakan. Tanpa disadari pewarna bibir ada yang mengandung pewarna yang berbahaya dan dilarang, karena dapat menyebabkan iritasi pada kulit dan saluran pernapasan, oleh karena itu, lebih baik digunakan bahan pewarna alami. Salah satu sumber pewarna alami adalah buah kesumba. Pembuatan ekstrak dari simplisia biji buah kesumba dilakukan secara perkolasi menggunakan penyari etanol 96%. Formula sediaan lipstik terdiri dari cera alba, vaselin alba, lanolin, carnauba wax, setil alkohol, oleum ricini, propilenglikol, titanium dioksida, butil hidroksi toluen, tween 80, minyak mawar (oleum rosae), dan nipagin serta penambahan ekstrak biji buah kesumba dengan konsentrasi 15%, 17,5%, 20%, 22,5% dan 25%. Pengujian terhadap sediaan yang dibuat meliputi pemeriksaan titik lebur, homogenitas, kekuatan lipstik, uji stabilitas terhadap perubahan bentuk, warna dan bau selama penyimpanan 30 hari pada suhu kamar, uji oles dan pemeriksaan pH, serta uji iritasi dan uji kesukaan (Hedonic test). Hasil penelitian ekstrak biji buah kesumba dapat diformulasi pada sediaan lipstik dengan warna kuning terang sampai merah maroon gelap. Formulasi ekstrak biji buah kesumba dalam sediaan lipstik menunjukkan sediaan yang dibuat cukup stabil, homogen, titik lebur 58°C, memiliki kekuatan lipstik yang balk, pH berkisar 6,3-5,7 (sesuai dengan pH kulit) mudah dioleskan dengan warna yang merata, tidak menyebabkan iritasi sehingga aman untuk digunakan, sediaan yang cukup disukai adalah sediaan 2, 3 dan 4 yaitu formula dengan ekstrak biji buah kesumba konsentrasi 17,5%, 20% dan 22,5%. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-12-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/76 10.36490/journal-jps.com.v4i2.76 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 74-80 2656-3088 10.36490/journal-jps.com.v4i2 eng https://www.journal-jps.com/index.php/jps/article/view/76/50 Copyright (c) 2021 Meutia Indriana, salman salman http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/78 2022-03-08T18:06:33Z jps:ART driver

Making Formulation of Tea Bags Combination of Kecibeling Leaves (Strobilanthes crispa (L.) Blume), Salam Leaves (Syzygium polyanthum (Wight.) Walp.) and Meniran Herbs (Phyllanthus niruri L.) As Antioxidants Siahaan, Desy Natalia Lubis, Salmah Handayani Fujiko, Muflihah Ginting, Ernawaty Purba, Pian Alatas The more incessantly the motto "back to nature" various types of plants in Indonesia are used by the community as traditional medicine. Kecibeling plants, salam and meniran herbs are one of the traditional medicinal ingredients that are often used. The potential development of the combination of kecibeling leaves, bay leaves and meniran herbs was chosen as a tea bag preparation because it is simple, cheap, and practical. The purpose of this study was to formulate a combination of kecibeling leaves, salam and meniran herbs as an antioxidant. This research was conducted by collecting fresh leaves of the kecibeling plant, salam and meniran herbs from Pematangsiantar, then used as simplicia and then formulated in teabags with varying weights. Then the formula is tested for characteristics which include water content test, pH test of the preparation, organoleptic test including hedonic test and antioxidant activity test.The results of testing the water content in each formula are 3.72%; 5.07% and 6.81%. The results of the pH test of teabag preparations from each formula were 6.7-7.Based on the results of the Hedonic test, Formula II with a weight of 0.95g was preferred by the panelists, so it was continued to be tested for activity as an antioxidant. The results of the antioxidant activity test showed that in Formula II (0.95 g) has antioxidant activity with the category "Medium". Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-12-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/78 10.36490/journal-jps.com.v4i2.78 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 81-92 2656-3088 10.36490/journal-jps.com.v4i2 eng https://www.journal-jps.com/index.php/jps/article/view/78/51 Copyright (c) 2022 Desy Natalia Siahaan, Salmah Handayani Lubis, Muflihah Fujiko, Ernawaty Ginting, Pian Alatas Purba http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/80 2022-03-08T18:06:33Z jps:ART driver

SEDATIVE EFFECT TEST OF ETHANOL EXTRACT OF RAMBUSA (Passiflora foetida L.) LEAVES TO MALE MICE (Mus musculus) UJI EFEKTIVITAS SEDATIF EKSTRAK ETANOL DAUN RAMBUSA (Passiflora foetida L.) TERHADAP MENCIT JANTAN (Mus musculus) saputri, muharni Sudewi, Sudewi Karimah, Nurul Nadia, Syarifah A common sleep disorder is insomnia, which occurs when a person has difficulty sleeping. One way to deal with insomnia is by giving sedative-hypnotic drugs. One of the plants used as ingredients in traditional medicine is the Rambusa (Passiflora foetida L.) plant. The ethanol extract of rambusa leaves contains alkaloid compounds, saponins, tannins, and steroids. These compounds can provide a sedative effect. This research was conducted to determine the sedative effect of rambusa leaf extract (Passiflora foetida L.) on mice (Mus musculus). This research is an experimental study with a maceration extraction method using 30 mice and divided into 5 groups. Group I (negative control) CMC 0.5%, group II (positive control) Diazepam, groups III, IV, V (treatment) of ethanol extract of rambusa leaves with a dose of 0.16 g / kgBB, 0.34 g / kgBB, 0, 68 g / kgBB. Giving to mice orally and observing body turning reflex, turning time and falling time using the Traction Test. The sedative effect test for each group was statistically analyzed using the SPSS 18.0 Post-Hoc Duncan test method. The results of the One Way ANOVA statistical test showed a significant difference between the treatment groups and the value P=0.000 (P<0.05). In Duncan's Post-Hoc test, doses II and III were not significantly different from diazepam. Doses II and III had the same sedative effect as diazepam. So it can be concluded that the ethanol extract of Rambusa leaves has a sedative effect.   Gangguan tidur yang umum terjadi adalah insomnia, yang terjadi saat seseorang mengalami kesulitan tidur. Salah satu cara untuk mengatasi insomnia adalah dengan memberikan obat sedatif-hipnotik. Salah satu tumbuhan yang digunakan sebagai bahan obat tradisional adalah tumbuhan Rambusa (Passiflora foetida L.). Ekstrak etanol daun rambusa mengandung senyawa alkaloid, saponin, tanin, dan steroid. Senyawa tersebut dapat memberikan efek sedatif. Penelitian ini dilakukan untuk mengetahui efek sedatif  ekstrak daun rambusa (Passiflora foetida L.) terhadap mencit (Mus musculus). Penelitian ini merupakan penelitian eksperimental dengan metode ekstraksi secara maserasi menggunakan 30 ekor mencit dan dibagi menjadi 5 kelompok. Kelompok I (kontrol negatif) CMC 0,5%, kelompok II (kontrol positif) Diazepam, kelompok III, IV, V (perlakuan) ekstrak etanol daun rambusa dosis 0,16 g/kgBB, 0,34 g/kgBB, 0,68 g/kgBB. Pemberian pada mencit secara oral dan mengamati reflek balik badan, waktu balik badan dan waktu jatuh menggunakan alat Traction Test. Uji efek sedatif tiap kelompok dianalisis secara statistik menggunakan metode uji Post-Hoc Duncan SPSS 18.0. Pada hasil uji statistik One Way ANOVA menunjukkan hasil perbedaan yang signifikan antara kelompok perlakuan dengan nilai P=0.000 (P<0.05). Pada uji Post-Hoc Duncan dosis II dan III tidak berbeda nyata dengan diazepam, dosis II dan III mempunyai efek sedatif yang sama dengan diazepam. Sehingga dapat disimpulkan bahwa Ekstrak Etanol daun Rambusa memberikan efek sedatif. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-12-18 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/80 10.36490/journal-jps.com.v4i2.80 Journal of Pharmaceutical And Sciences; Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021); 93-100 2656-3088 10.36490/journal-jps.com.v4i2 ind https://www.journal-jps.com/index.php/jps/article/view/80/52 Copyright (c) 2022 muharni saputri http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/83 2022-04-19T16:40:28Z jps:ART driver

ACTIVITY ETHANOL EXTRACT OF MANGGA (Curcuma mangga Val.) FEET UDEM RAT WHITE ACTIVITY ETHANOL EXTRACT OF MANGGA (Curcuma mangga Val.) FEET UDEM RAT WHITE salman, salman Indriana, Meutia The rhizome of mango Curcuma is empirically used as a traditional medicine for the treatment of gastric pain, pain, and inflammation due to hemorrhoids, sore throat, bronchitis, and asthma. The aim of this study was to determine the chemical compound content of secondary metabolites and the activity of the ethanol extract of Temu Mango (Curcuma mangga Val.) on the reduction of carrageenan-induced rat paw edema. The results of a preliminary examination of the chemical content of the rhizome of Intersection mango (Curcuma mango Val.) showed the presence of glycosides, flavonoids, saponins, essential oils, and steroids. In general, the suspension of the ethanol extract of Temu Mango at doses of 50, 100, 200 mg/kg BW gave an anti-inflammatory effect that began to appear in the first half-hour and continued to increase with increasing time. An increase of 2 times the dose of the ethanol extract of Temu Mango showed an anti-inflammatory effect that was not significantly different, but with an increased dose of 4 times, it showed a significant difference. Even the ethanol extract of Intersection mango at a dose of 200 mg/kg BW gave almost the same effect as indomethacin. Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-08-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/83 10.36490/journal-jps.com.v2i2.83 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 41-46 2656-3088 10.36490/journal-jps.com.v2i2 eng https://www.journal-jps.com/index.php/jps/article/view/83/54 Copyright (c) 2022 salman salman, Meutia Indriana http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/84 2022-03-09T10:19:26Z jps:ART driver

DETERMINATION OF DILTIAZEM HCI LEVELS IN TABLETS ULTRAVIOLET SPECTROPHOTOMETRY PENETAPAN KADAR DILTIAZEM HCI DALAM SEDIAAN TABLET SECARA SPEKTROFOTOMETR ULTRAVIOLET salman, salman Indriana, Meutia The rhizome of mango Curcuma is empirically used as a traditional medicine for the treatment of gastric pain, pain, and inflammation due to hemorrhoids, sore throat, bronchitis, and asthma. The aim of this study was to determine the chemical compound content of secondary metabolites and the activity of the ethanol extract of Temu Mango (Curcuma mangga Val.) on the reduction of carrageenan-induced rat paw edema. The results of a preliminary examination of the chemical content of the rhizome of Intersection mango (Curcuma mango Val.) showed the presence of glycosides, flavonoids, saponins, essential oils, and steroids. In general, the suspension of the ethanol extract of Temu Mango at doses of 50, 100, 200 mg/kg BW gave an anti-inflammatory effect that began to appear in the first half-hour and continued to increase with increasing time. An increase of 2 times the dose of the ethanol extract of Temu Mango showed an anti-inflammatory effect that was not significantly different, but with an increased dose of 4 times, it showed a significant difference. Even the ethanol extract of Intersection mango at a dose of 200 mg/kg BW gave almost the same effect as indomethacin. Diltiazem adalah obat yang dikenal sebagai derivat benzothiazepin yang termasuk dalam kelompok antagonis kalsium, digunakan dalam pengobatan hipertensi, angina pektoris dan aritmia. Tujuan dari penetian ini adalah mengaplikasikan metode spektrofotometri dan menentukan kadar diltiazem dalam sedian tablet generik dan nama dagang yang terdapat di pasaran. Metode yang digunakan yaitu secara spektrofotometri ultraviolet dalam pelarut HCI 0,1 N pada panjang gelombang 236 nm. Metode ini memiliki beberapa keuntungan antara lain dapat digunakan untuk analisis suatu zat dalam jumlah kecil, pengerjaannya cepat dan relatif lebih murah dibandingkan dengan metode Kromatografi Cair Kinerja Tinggi (KCKT). Dan hasil penentuan kadar tablet yang ferdapat di pasaran diperoleh kadar untuk tablet diltiazem generik (Kimia Farma) 107,69 ± 0,31%, tablet diltiazem generik (Indofarma) 96,97 ± 0,26%, tablet nama dagang Farmabes®(Fahrenheit) 92,20 ± 0,86%., Herbesser®(Tanabe)gg 06 $, 0,33% dan Dilmen® (Sanbe) 100,96± 0,52%. Semua tablet yang ditentukan memenuhi persyaratan kadar menurut Farmakope Indonesia edisi IV tahun 1995 yaitu tidak kurang dari 90,0% dan tidak lebih dari 110,0% dari jumlah yang tertera pada etiket. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-06-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/84 10.36490/journal-jps.com.v3i1.84 Journal of Pharmaceutical And Sciences; Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020); 58-61 2656-3088 10.36490/journal-jps.com.v3i1 eng https://www.journal-jps.com/index.php/jps/article/view/84/55 Copyright (c) 2020 salman salman, Meutia Indriana http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/85 2022-03-09T10:17:21Z jps:ART driver

DETERMINATION OF PARACETAMOL LEVELS IN TABLETS AND ORAL SOLUTIONS BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) PENENTUAN KADAR PARASETAMOL DALAM SEDIAAN TABLET DAN LARUTAN ORAL SECARA KROMATOGRAFI CAIR KINERJA TINGGI (KCKT) salman, salman Indriana, Meutia According to RI Law no. 36 of 2009, determining the level of efficacious substances from a drug preparation is one of the requirements that must be carried out to ensure the quality of the drug preparation. Drug preparations of good quality will provide the expected effect and one of the parameters is the level of the active substance of the drug must meet the level requirements listed in the Indonesian Pharmacopeia or other standard books. The purpose of this study was to determine the levels of Paracetamol in tablet preparations and oral solution by high-performance liquid chromatography. The determination of the concentration was carried out by the HPLC method using a 2.5 mm x 25 cm VP-ODS shim pack column with water-methanol as a mobile phase (3:1), a flow rate of approximately 1.5 ml/minute, and the detection was carried out at a wavelength of 243 nm. The advantage of the HPLC method is the separation system with high speed and efficiency because it is supported by advances in column technology, high-pressure pump systems, and highly sensitive and diverse detectors so that they are able to analyze various samples qualitatively and quantitatively, back in single or mixed components. The results showed that all the specified samples met the content requirements according to the Indonesian Pharmacopeia IV edition 1995, namely not less than 90.0% and not more than 110.0% of the amount stated on the label. The results of the Validation test method carried out obtained a recovery percent of 99.96% with an RSD (Relative Standard Deviation) of 1.81% so that it can be concluded that this method has good sensitivity and accuracy, with a LOD (limit of detection) 0.76 g/ml and LOQ (limit of quantitation) 2.56 g/ml. Menurut undang-undang RI No. 36 tahun 2009, penentuan kadar zat berkhasiat dari suatu sediaan obat merupakan salah satu persyaratan yang harus dilakukan untuk menjamin mutu dari sediaan obat tersebut. Sediaan obat yang mutunya baik akan memberikan efek yang diharapkan dan salah satu parameternya adalah kadar zat aktif dari obat tersebut harus memenuhi persyaratan kadar yang tercantum dalam Farmakope Indonesia atau buku standar Lainnya. Tujuan penelitian ini adalah untuk menetapkan kadar Parasetamol dalam sediaan tablet dan larutan oral secara kromatografi cair kinerja tinggi. Penentuan kadar dilakukan dengan metode KCKT menggunakan kolom shim pack VP-ODS 2,5 mm x 25 cm) dengan fase gerak air - metanol (3:1), laju alir lebih kurang 1,5 ml/menit, dan deteksi dilakukan pada panjang gelombang 243 nm. Keuntungan metode KCKT yaitu sistem pemisahan dengan kecepatan dan efisiensi yang tinggi karena didukung oleh kemajuan dalam teknologi kolom, sistem pompa tekanan tinggi, dan detektor yang sangat sensitif dan beragam sehingga mampu menganalisis berbagai cuplikan secara kualitatif maupun kuantitatif, balik dalam komponen tunggal maupun campuran. Hasil penelitian menunjukkan bahwa semua sampel yang ditentukan memenuhi persyaratan kadar menurut Farmakope Indonesia edisi IV 1995, yaitu tidak kurang dari 90,0% dan tidak lebih dari 110,0% dari jumlah yang tertera pada etiket. Hasil uji Validasi Metode yang dilakukan diperoleh persen Recovery 99,96% dengan RSD (Relatif Standar Deviasi) 1,81 % sehingga dapat disimpulkan metode ini memiliki kepekaan dan ketelitian yang baik, dengan LOD (limit of detection) 0,76 µg/ml dan LOQ (limit of quantitation) 2,56 µg/ml.   Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-11-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/85 10.36490/journal-jps.com.v3i2.85 Journal of Pharmaceutical And Sciences; Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020); 106-113 2656-3088 10.36490/journal-jps.com.v3i2 eng https://www.journal-jps.com/index.php/jps/article/view/85/56 Copyright (c) 2020 salman salman, Meutia Indriana http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/86 2022-04-19T16:41:05Z jps:ART driver

PATTERNS OF USING GARLIC AS A TRADITIONAL MEDICINE IN HELPING TREAT THE FLU IN SUMUR VILLAGE PATTERNS OF USING GARLIC AS A TRADITIONAL MEDICINE IN HELPING TREAT THE FLU IN SUMUR VILLAGE Indriana, Meutia salman, salman The purpose of this study was to determine the pattern of use of garlic in the Sumur Village community and know the effectiveness of garlic as a traditional medicine in helping treat flu: non-experimental/observational research. Data analysis used a descriptive cross-sectional design by measuring LL The use of garlic in treating flu. The study was carried out from July 25 to September 12. This study indicates that the people in Sumur Village are still inseparable from their traditions, including very traditional methods of treating flu. Garlic contains sulfur which gives it a distinctive smell and taste that can increase and speed up the activity of the mucous membranes in the respiratory tract. Garlic is better and safer if before. In consumption, garlic is burned or heated first because the nutritious sulfur content has been released and the ester and protein bonds are in this situation, it will be more practical, and garlic which can disrupt the stomach atmosphere, will be safer for garlic users who have a history of ulcers. Garlic contains essential sulfur compounds and 17 amino acids, including eight amino acids and minerals such as calcium, iron, potassium, germanium, selenium, and zinc. One of these sulfur compounds is Alliin. Alliin is easy to turn into Allicin when fresh garlic is chopped, chopped, or chewed directly. The conversion of Alliin to Allicin is assisted by a particular enzyme called allinase. Allicin has the potential as an anti-bacterial; the workings of Allicin are similar to penicillin antibiotics and their derivatives, for example, Amoxicillin: The way it works is by inhibiting the formation of proteins in the bacterial cell wall so that later it can cause defects in the bacterial cell wall which eventually makes the bacteria die because its metabolic system is disrupted. However, one thing to note is that sprouted garlic is not suitable for consumption because the shoots contain the poison HCN (cyanide).   Fakultas Farmasi Universitas Tjut Nyak Dhien 2019-08-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/86 10.36490/journal-jps.com.v2i2.86 Journal of Pharmaceutical And Sciences; Vol 2 No 2 (2019): JPS Volume 2 Nomor 2 (2019); 47-55 2656-3088 10.36490/journal-jps.com.v2i2 eng https://www.journal-jps.com/index.php/jps/article/view/86/57 Copyright (c) 2019 Meutia Indriana, salman salman http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/87 2022-03-09T10:17:21Z jps:ART driver

PHYTOCHEMICAL SCREENING AND EFFICACY AS AN ANTIOXIDANT FROM GUAVA LEAVES SKRINING FITOKIMIA DAN UJI KEMAMPUAN SEBAGAI ANTIOKSIDAN DARI DAUN JAMBU BIJI salman, salman Indriana, Meutia Free radicals are molecules that have free electrons, very harmful to health. One of the efforts to overcome it is with antioxidants. Naturally, in the body, there are antioxidants, namely superoxide dismutase, glutathione, and catalase, but depending on food intake, especially containing phenolics and flavonoids. Traditionally, guava leaves are used to treat diarrhea, dysentery, lower cholesterol, irregular menstruation, wounds, and canker sores. Judging from these various properties, it is possible that guava leaves contain chemical compounds that have the potential as antioxidants, especially phenolic compounds, the authors tested the ability of guava leaves as antioxidants. Guava leaves were prepared into ethanol extract, fractionated with n-hexane, ethyl acetate, and water, and phytochemical screening was carried out on the ethanol extract and each fraction. Antioxidant testing was carried out using the Radical Scavenger using 1,1-diphenyl-2-picrylhydrazyl. The test results showed that the ethanol extract contained alkaloids, tannins, flavonoids, steroids, saponins, and glycosides. The n-hexane fraction contains alkaloids and glycosides. the ethyl acetate fraction contains tannins. the water fraction contains tannins and glycosides. As antioxidants, ethanol extract and water fraction were categorized as strong with IC50 ethanol = 42.06 g/ml, water fraction = 49.41 g/mL, n-hexane and ethyl acetate fractions were categorized as medium with IC50 fraction n-hexane = 58.15 g /mL, ethyl acetate fraction = 51.60 g/ml. Radikal bebas merupakan molekul yang mempunyai elektron bebas, sangat mengganggu kesehatan. Salah satu upaya penanggulangannya dengan antioksidan. Secara alamiah di dalam tubuh terdapat antioksidan yaitu superoksida dismutase, glutation dan katalase, tetapi tergantung pada asupan makanan terutama mengandung fenolik dan flavonoid. Secara tradisional daun jambu biji digunakan untuk mengobati diare, disentri, menurunkan kolesterol, haid tidak teratur, luka, dan sariawan. Dilihat dari berbagai khasiat ini kemungkinan daun jambu biji mengandung senyawa kimia yang berpotensial sebagai antioksidan, terutama senyawa fenolik, maka penulis menguji kemampuan daun jambu biji sebagai antioksidan. Daun jambu biji disiapkan menjadi ekstrak etanol, difraksinasi dengan n-heksan, etil asetat dan air, dilakukan skrining fitokimia terhadap ekstrak etanol dan masing-masing fraksi. Pengujian antioksidan dilakukan dengan metode Radical Scavenger menggunakan 1,1-diphenyl-2-picrylhydrazyl. Hasil pengujian menunjukkan ekstrak etanol mengandung alkaloid, tanin, flavonoid, steroid, saponin, dan glikosida. fraksi n-heksan mengandung alkaloid dan glikosida. fraksi etil asetat mengandung tanin. fraksi air mengandung tanin dan glikosida. Sebagai antioksidan ekstrak etanol dan fraksi air berkategori kuat dengan IC50 etanol =42,06 g/ml, fraksi air = 49,41 g/mI, fraksi n-heksan dan etil asetat berkategori sedang dengan IC50 fraksi n-heksan = 58,15 g/ml, fraksi etil asetat =51,60 g/ml. Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-06-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/87 10.36490/journal-jps.com.v4i1.87 Journal of Pharmaceutical And Sciences; Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021); 41-47 2656-3088 10.36490/journal-jps.com.v4i1 eng https://www.journal-jps.com/index.php/jps/article/view/87/58 Copyright (c) 2021 salman salman, Meutia Indriana http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/89 2022-03-09T10:19:26Z jps:ART driver

POTENTIAL ANTI-BACTERIAL POWDER BOOTING WATER, n-HEXANA EXTRACT AND EARTHWORM CHLOROFORM EXTRACT (Peryonix sp.) AGAINST Salmonella typhosa BACTERIA POTENSI ANTIBAKTERI AIR REBUSAN SERBUK, EKSTRAK n-HEKSANA DAN EKSTRAK KLOROFORM CACING TANAH ( Perionyx sp.) TERHADAP BAKTERI Salmonella typhosa Indriana, Meutia salman, salman Earthworms are animals that have many benefits and are easy to find—results of information from people consume boiled water of earthworms three times a day for 7 days is used as a typhus medicine, other information is obtained from electronic media, many people also consume earthworms as a typhoid medicine in powder form which is filled into capsules Which can be found in Chinese drug stores, but until now scientific research on earthworms (Perionyx sp.) as an anti-bacterial has not been done. Extraction is done by maceration. Multilevel maceration using chloroform and n-hexane as solvent. The class of chemical compounds was determined on the ethyl acetate extract and the n-hexane extract of the earthworm Perionyx sp.), including alkaloids, glycosides, steroids/triterpenoids, flavonoids, saponins, and tannins. Testing of antibacterial activity of chloroform extract and n-hexane extract against Salmonella typhosa was carried out in vitro by agar diffusion method using metal buffer at a concentration of 500 mg/ml; 400 mg/ml; 300 mg/ml; 200 mg/ml; 100 mg/ml and 50 mg/ml. The results of determining the class of chemical compounds from the chloroform extract of earthworms (Perionyx sp.) showed the presence of chemical compounds belonging to the alkaloid group, while the n-hexane extract did not indicate the presence of chemical compounds detected. The n-hexane extract of tar h (Perionyx sp.) had an inhibitory effect on the growth of Salmonella typhosa at a minimum inhibitory concentration of 400 mg/ml of 10.9mm, while the chloroform extract had a minimum inhibitory concentration of 300 mg/ml with an inhibitory diameter of 12.87 mm. Cacing tanah adalah hewan yang mempunyai banyak khasiat dan mudah untuk ditemukan. Hasil informasi dari masyarakat bahwa, mengkonsumsi air rebusan cacing tanah tiga kali sehari selama 7 hari digunakan sebagai obat tifus, informasi lain diperoleh dari media elektronik, banyak masyarakat Juga mengkonsumsi cacing tanah sebagai obat tifus dalam bentuk serbuk yang diisi kedalam kapsul Yang dapat dijumpai di toko obat Cina, namun sampai sekarang penelitian secara ilmiah mengenai Cacing tanah (Perionyx sp.) sebagai antibakteri belum dilakukan. Ekstraksi dilakukan dengan cara maserasi. maserasi bertingkat menggunakan pelarut kloroform dan pelarut n-heksana. Penentuan golongan senyawa kimia dilakukan terhadap ekstrak etil asetat dan ekstrak n-heksana cacing tanah Perionyx sp.) meliputi golongan senyawa alkaloid, glikosida, steroida/triterpenoida, flavonoid, saponin dan tannin. Pengujian aktivitas antibakteri ekstrak kloroform dan ekstrak n-heksana terhadap bakteri Salmonella typhosa dilakukan secara in vitro dengan metode difusi agar menggunakan pencadang logam pada konsentrasi 500 mg/ml; 400 mg/ml; 300 mg/ml; 200 mg/ml; 100 mg/ml dan 50 mg/ml. Hasil penentuan golongan senyawa kimia dari ekstrak kloroform cacing tanah (Perionyx sp.) menunjukan adanya senyawa kimia golongan alkaloid, sedang ekstrak n-heksana tidak ada menunjukkan adanya senyawa kimia yang terdeteksi. Ekstrak n-heksana cacing tar h (Perionyx sp.) memiliki daya hambat terhadap pertumbuhan bakteri Salmonella typhosa pada konsentrasi hambat minimum 400 mg/ml sebesar 10,9mm, sedang ekstrak kloroform memiliki konsentrasi hambat minimum 300 mg/ml dengan diameter hambat 12,87 mm. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-06-03 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/89 10.36490/journal-jps.com.v3i1.89 Journal of Pharmaceutical And Sciences; Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020); 62-68 2656-3088 10.36490/journal-jps.com.v3i1 eng https://www.journal-jps.com/index.php/jps/article/view/89/59 Copyright (c) 2020 Meutia Indriana, salman salman http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/90 2022-08-09T23:16:02Z jps:ART driver

SKIN EXTRACT OF GRAPE (Vitis vinifera L) AS DYES IN LIPSTICK FORMULATION EKSTRAK KULIT BUAH ANGGUR (Vitis vinifera L) SEBAGAI PEWARNA PADA FORMULASI LIPSTIK salman, salman Indriana, Meutia Grapes (Vitis vinifera L.) belong to the family Vitaceae. The color of the fruit varies. There are red, green and purple. The color of this wine contains anthocyanin dyes that can be used as natural dyes to replace synthetic dyes, the colors they contain are pretty intensive, so the researchers aimed to make lipstick formulations using natural dyes from grape skins. The lipstick formulation consisted of Cera alba, lanolin, vaseline alba, cetyl alcohol, oleum ricini, carnauba wax, propylene glycol, titanium dioxide, oleum rosae, butylhydroxytoluene, tween 80, and nipagin, as well as the addition of grape skin extract with a concentration of 15 %, 20%, 25%, 30%, and 35%. Tests on the preparations made include inspection of homogeneity, melting point, lipstick strength, stability test against changes in shape, color, and odor during 30 days of storage at room temperature, smear test, pH examination, and irritation test preference test (Hedonic test). From the research results, grape skin extract can be formulated into lipstick preparations with pink to dark red colors. Lipstick preparations with grape skin extract as a dye are pretty stable, homogeneous, melting point 59°C, have good lipstick strength, pH ranges from 3.7 to 3.9 (close to the pH of the lip skin) are easy to apply with an even color, and do not irritate. Irritation the preparation preferred by 30 panelists was preparation with a concentration of 25%. Buah anggur (Vitis vinifera L.) termasuk famili Vitaceae. Warna buahnya beraneka ragam. Ada yang merah, hijau dan ungu. Warna anggur ini mengandung zat warna antosianin yang dapat digunakan sebagai bahan pewarna alami pengganti pewarna sintetik, warna yang dikandungnya cukup intensif, sehingga peneliti bertujuan membuat formulasi sediaan lipstik dengan menggunakan pewarna alami dari kulit buah anggur. Formulasi sediaan lipstik terdiri dari cera alba, lanolin, vaselin alba, setil alkohol, oleum ricini, carnauba wax, propilen glikol, titanium dioksida, oleum rosae, butil hidroksi toluen, tween 80, dan nipagin, serta penambahan ekstrak kulit buah anggur dengan konsentrasi 15%, 20%, 25%, 30%, dan 35%. Pengujian terhadap sediaan yang dibuat meliputi pemeriksaan homogenitas, titik lebur, kekuatan lipstik, uji stabilitas terhadap perubahan bentuk, warna dan bau selama penyimpanan 30 hari pada suhu kamar, uji oles, dan pemeriksaan pH, serta uji iritasi dan uji kesukaan (Hedonic test). Dari hasil penelitian, ekstrak kulit anggur dapat diformulasi menjadi sediaan lipstik dengan warna merah muda sampai merah tua. Sediaan lipstik dengan ekstrak kulit anggur sebagai pewarna cukup stabil, homogen, titik lebur 59°C, memiliki kekuatan lipstik yang baik, pH berkisar 3,7-3,9 (mendekati pH kulit bibir) mudah dioleskan dengan warna yang merata, serta tidak menyebabkan iritasi. Sediaan yang disukai oleh 30 orang panelis adalah sediaan dengan konsentrasi 25%.   Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-01-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/90 10.36490/journal-jps.com.v5i1.90 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 1-11 2656-3088 10.36490/journal-jps.com.v5i1 eng https://www.journal-jps.com/index.php/jps/article/view/90/60 Copyright (c) 2022 salman salman, Meutia Indriana http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/91 2022-03-09T10:17:21Z jps:ART driver

THE EFFECT OF BEEF FAT INTERESTERIFICATION ON THE GUINEA PIG'S LIPID PROFILE PENGARUH INTERESTERIFIKASI LEMAK SAPI TERHADAP PROFIL LIPIDA MARMUT Indriana, Meutia salman, salman Properties of fats are determined by the composition and position (sn-1,2,3) of fatty acids in the fat molecule. Palmitic acid is one of the most atherogenic fatty acids in the sn-2. Interesterification will change the position of palmitic acid in the fat molecule. This study aimed to determine the effect of interesterification on the atherogenic properties of fat. The fat used was beef, extracted by dry rendering, and chemically interesterified using a Na-methoxide catalyst for 20, 30, 60, 90, and 120 minutes. The melting point of the fat was measured using a melting point apparatus then given to guinea pigs. For 21 days, the propyl lipid was measured using the enzymatic method using a micro lab 300 spectrophotometers. The melting point of beef fat from interesterification for 60 minutes was constant, meaning the reaction was complete. Interesterification of beef fat showed an increase in atherogenicity seen from the increase in total cholesterol, triglyceride, LDL and decreased HDL levels after interesterification, respectively 69.20 ± 20.24; 68.60 ± 18.81; 40.43 ± 15.18; 14.33 ± 3.01 mg/dl compared with no interesterification 62.27 ± 16.02; 62.87 ± 14.08; 37.84 ± 13.41; 11.80 ± 2.15 mg/dl (ANOVA, P < 0.05). Sifat aterogenik lemak ditentukan oleh komposisi dan posisi (sn-1,2,3) asam lemak dalam molekul lemak Asam palmitat merupakan salah satu asam lemak yang paling bersifat aterogenik jika berada pada posisi sn-2. Interesterifikasi akan mengubah posisi asam palmitat dalam molekul lemak. Tujuan penelitian ini adalah untuk mengetahui pengaruh interesterifikasi terhadap sifat aterogeniklemak. Lemak yang digunakan adalah lemak sapi yang diekstraksi dengan cara dry rendering dan diinteresterifikasi secara kimia dengan menggunakan katalisator Na-metoksida selama 20, 30, 60, 90, dan 120 menit, kemudian titik lebur lemak diukur dengan menggunakan melting point apparatus, kemudian diberikan pada marmut secara oral selama 21 hari lalu dilakukan pengukuran propil lipida dengan metode enzimatis menggunakan spektrofotometer mikrolab 300. Hasil pengukuran titik lebur lemak sapi hasil interesterifikasi selama 60 menit sudah konstan artinya reaksi sudah sempurna. Interesterifikasi lemak sapi menunjukkan adanya peningkatan aterogenisitas dilihat dari peningkatan kadar kolesterol total, trigliserida, LDL dan penurunan kadar HDL setelah interesterifikasi berturut-turut sebesar 69,20 ± 20,24; 68,60 ± 18,81; 40,43 ± 15,18; 14,33 ± 3,01 mg/dl dibandingkan dengan tanpa interesterifikasi 62,27 ± 16,02; 62,87 ± 14,08; 37,84 ± 13,41; 11,80 ± 2,15 mg/dl (ANOVA, P < 0,05). Fakultas Farmasi Universitas Tjut Nyak Dhien 2021-06-26 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/91 10.36490/journal-jps.com.v4i1.91 Journal of Pharmaceutical And Sciences; Vol 4 No 1 (2021): JPS Volume 4 Nomor 1 (2021); 48-54 2656-3088 10.36490/journal-jps.com.v4i1 eng https://www.journal-jps.com/index.php/jps/article/view/91/61 Copyright (c) 2021 Meutia Indriana, salman salman http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/92 2022-03-09T10:17:21Z jps:ART driver

UTILIZATION OF NEMBA STEM AS AN ANTITUBERCULOSIS COMPARED WITH RIFAMPICIN AND ETAMBUTOL PEMANFAATAN KULIT BATANG MIMBA SEBAGAI ANTITUBERKULOSIS DIBANDINGKAN DENGAN RIFAMPISIN DAN ETAMBUTOL Indriana, Meutia salman, salman Indonesia ranks third in the number of tuberculosis, after India and China. Treatment of tuberculosis takes a long time, and the lack of discipline in taking medication has caused the Mycobacterium tuberculosis to be resistant to many synthetic drugs that have been used so far. In contrast, the discovery of new synthetic drugs is very slow. Traditionally, neem bark (Azadirachta indica JUSS.) has been used to treat coughing up blood and phlegm, and the results of previous studies show that ethanol extract of neem bark in vitro can inhibit the growth of Mycobacterium tuberculosis. This study was conducted to determine the toxicity of neem bark extract, formulation of neem bark ethanol extract into tablet preparations, and the potential of this tablet preparation as anti-tuberculosis in vivo in animals. Neem bark extract was made by percolation using an ethanol extractor. Toxicity test was carried out in the form of an acute toxicity test on mice to calculate the LD50 value and histopathological observations of the liver, lungs, and intestines. The tablets were made by wet granulation. The potential test of tablet preparations as anti-tuberculosis was performed in vivo on animals infected with Mycobacterium tuberculosis H37Rv using a nebulizer. The results showed LD 50 = 11.85 ± 0.571, including mild toxic. The ethanolic extract of neem bark can be formulated into tablets using a 6% gelatin binder, Manihot starch and primojel as a binder, and a mixture of starch and lactose as a filler. Neem bark extract tablets can cure tuberculosis of experimental animals that have been infected with Mycobacterium tuberculosis H37RV, which is given a dose of 3 times a day two tablets (50 mg/tablet) for six weeks seen tuberculosis bacteria from +3 to negative, and a dose of 3 times a day once a day. Tablet looks from +3 to +1. Indonesia menduduki urutan ketiga dalam jumlah penderita tuberkulosis, setelah India dan Cina. Pengobatan tuberkulosis membutuhkan waktu yang panjang, dan kurangnya disiplin makan obat menyebabkan bakteri Mycobacterium tuberculosis sudah banyak yang resisten terhadap obat sintetis yang telah digunakan selama ini, sementara penemuan obat sintetis baru sangat lambat. Secara tradisional kulit batang mimba (Azadirachta indica JUSS.) telah digunakan untuk mengobati batuk berdarah dan berdahak, dan hasil penelitian sebelumnya bahwa ekstrak etanol kulit batang mimba secara in vitro dapat menghambat pertumbuhan bakteri Mycobacterium tuberculosis. Penelitian ini dilakukan untuk mengetahui toksisitas ekstrak kulit batang mimba, formulasi ekstrak etanol kulit batang mimba menjadi sediaan tablet, dan potensi sediaan tablet ini sebagai anti tuberkulosis secara in vivo pada hewan. Ekstrak kulit batang mimba dibuat secara perkolasi menggunakan penyari etanol. Uji toksisitas dilakukan berupa uji toksisitas akut pada hewan mencit dengan perhitungan harga LD50 dan pengamatan histopatologi organ hati, paru dan usus. Pembuatan tablet dilakukan dengan cara granulasi basah, dan uji potensi sediaan tablet sebagai antituberkulosis dilakukan secara in vivo pada hewan yang diinfeksikan dengan Mycobacterium tuberculosis H37Rv menggunakan nebulizer. Hasil penelitian menunjukkan LD 50 = 11.85 ± 0.571, termasuk kategori toksik ringan. Ekstrak etanol kulit batang mimba dapat diformulasikan menjadi tablet menggunakan bahan pengikat gelatin 6 %, pengembang amilum manihot dan primojel, pengisi campuran amilum dan laktosa sama banyak. Tablet ekstrak kulit batang mimba dapat menyembuhkan tuberkulosis hewan percobaan yang telah diinfeksikan dengan Mycobacterium tuberculosis H37RV, yaitu pemberian dosis 3 kali sehari 2 tablet (50 mg/tablet) selama 6 minggu terlihat bakteri tuberkulosis dari +3 menjadi negatif, dan dosis 3 kali sehari satu tablet terlihat dari +3 menjadi +1. Fakultas Farmasi Universitas Tjut Nyak Dhien 2020-11-11 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/92 10.36490/journal-jps.com.v3i2.92 Journal of Pharmaceutical And Sciences; Vol 3 No 2 (2020): JPS Volume 3 Nomor 2 (2020); 114-119 2656-3088 10.36490/journal-jps.com.v3i2 eng https://www.journal-jps.com/index.php/jps/article/view/92/62 Copyright (c) 2020 Meutia Indriana, salman salman http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/93 2022-08-09T23:16:02Z jps:ART driver

Adsorption of Naphtol Blue Black (NBB) Dye over Immobilized Chitosan from Shrimp Shells onto Glass Plate Adsorpsi Zat Warna Naphtol Blue Black (NBB) Menggunakan Kitosan dari Cangkang Udang yang Terimobilisasi pada Pelat Kaca sheilatina, sheilatina Fathurrahmi, Fathurrahmi Robbani, Fathur The adsorption of naphtol blue black (NBB) dye using immobilized chitosan on the glass plates had been investigated. The chitosan is derived from chitin deacetylation shrimp shells waste with the degree of deacetylation of chitosan is 75.7%. The produced chitosan were analyzed using FTIR and SEM. The effects of different reaction parameters such as mass of adsorbent, initial pH of solution and initial dye concentration were studied for the adsorption NBB dye. The results from this research showed that 30 mg of adsorbent mass at initial pH 6.0 yielded the optimum conditions for the adsorption of 30 mg/L NBB dye solution at the immobilized chitosan interface with the percentage removal of the dye is 97.187%. The equilibrium adsorption data of this research were analyzed by Langmuir and Freundlich isotherm models.  The maximum adsorption capacity is obtained by using Freundlich isotherm with a correlation coefficient (R2) for 0,989 is greater than the value (R2) 0.968 of Langmuir isotherm which the nF and Kf values were 3.56 and 41.78 L/g respectively. The maximum adsorption capacity (qmax) calculated from the Langmuir model is found to be 45,45 mg/g. The kinetics of the NBB dye adsorption nicely followed the pseudo-first rate which demonstrates that physisorption is the possible rate-limiting step controlling the adsorption process in this research. Adsorpsi zat warna Naphtol Blue Black (NBB) Menggunakan khitosan terimobilisasi pada pelat kaca telah diteliti. Khitosan diperoleh dari deasetilasi khitin pada kulit udang dengan derajat deaasetilasi khitosan sebesar 75,7%. Khitosan yang dihadlikan dianalisis menggunakan FTIR dan SEM. Pengaruh perbedaan parameter reaksi seperti massa adsorben, pH awal larutan dan konsnetrasi awal zat warna dipelajari untuk adsorpsi zat warna NBB. Hadil dari penelitian ini menunjukkan bahwa 30 mg massa adsorben pada pH awal 6,0 menghadilkan kondisi optimum untuk adsorpsi 30 mg/L larutan zat warna NBB pada khitosan terimobilisasi dengan persentase penyerapan zat warna sebesar 97,187%. Kesetimbangan data adsorpsi dari penelitian ini dianalisis dengan model isotherm Langmuir dan Freundlich. Kapasitas adsorpsi maksimum diperoleh menggunakan isoterm Freundlich dengan nilai koefisien korelasi (R2) 0,989 lebih besar dibandingkan nilai (R2) 0,968 dari isoterm Langmuir dimana nilai nF dan Kf masing-masing 3,56 dan 41,78 L/g. Kapasitas adsorpsi maksimum (qmax) dihitung menggunakan model Langmuir yaitu 45,45 mg/g. Kinetika dari adsorpsi zat warna NBB baik mengikuti laju kinetika ode satu semu yang menunjukkan bahwa fisisorpsi kemungkinan sebagai laju pembatas yang mengontrol proses adsorpsi pada penelitian ini. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-05-23 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/93 10.36490/journal-jps.com.v5i1.93 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 21-32 2656-3088 10.36490/journal-jps.com.v5i1 eng https://www.journal-jps.com/index.php/jps/article/view/93/67 Copyright (c) 2022 sheilatina sheilatina http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/96 2022-08-09T23:16:02Z jps:ART driver

IDENTIFICATION OF FORMALDEHYDE IN PROCESSED MEAT AT THE TRADITIONAL MARKET OF MEDAN CITY USING UV-VIS SPECTROPHOTOMETRY METHOD IDENTIFIKASI KANDUNGAN FORMALDEHIDA YANG TERDAPAT PADA DAGING OLAHAN YANG BEREDAR DIPASAR TRADISIONAL KOTA MEDAN DENGAN METODE SPEKTROFOTOMETRI UV-VIS maulina, syarifah nadia Ginting, Ernawati Processed meat is a ready-to-eat food that is very popular, so many food producers are competing to produce food that is in great demand by the public, especially among children. Nugget is one of the processed meat products made from ground beef that requires preservatives in it so that it can last for a long time. Nuggets are widely consumed because they have an interesting taste and texture. Formaldehyde is a preservative that is prohibited from being used as a food preservative because it can cause cancer in humans, but formaldehyde is widely used by the public as a preservative without knowing the dangers of formaldehyde itself. This study was conducted to determine the level of formaldehyde contained in processed meat circulating in the traditional market of Medan City. This research is a descriptive study using UV-VIS spectrophotometry method measured at a wavelength of 585 nm with operating time at 29 minutes and 30 minutes using Schiff reagent. The results of the analysis showed that the levels of formaldehyde contained in some processed meat circulating in the traditional market had levels (0.3050 ± 0.0241 g/g) and (0.6543 ± 3.2353 g/g). From the results of the study, it can be concluded that some processed meats circulating in traditional markets contain formaldehyde. Daging olahan merupakan makanan siap saji yang sangat disukai, sehingga banyak produsen makanan yang berlomba-lomba menghasilkan makanan yang banyak diminati oleh masyarakat terutama dI kalangan anak-anak. Nugget merupakan salah satu produk daging olahan yang terbuat dari daging giling yang memerlukan bahan pengawet didalamnya agar dapat bertahan dalam waktu yang lama. Nugget banyak dikonsumsi karena memiliki rasa dan tekstur yang menarik. Formaldehid merupakan pengawet yang dilarang pemakaiannya sebagai pengawet makanan karena dapat menyebabkan kanker pada manusia, namun formaldehida banyak digunakan oleh masyarakat sebagai bahan pengawet tanpa mengetahui bahaya dari formaledhida itu sendiri. Penelitian ini dilakukan untuk mengetahui kadar formaldehida yang terdapat dalam daging olahan yang beredar dipasar tradisional Kota Medan. Penelitian ini merupakan penelitian deskriptif dengan metode spektrofotometri UV-VIS yang diukur pada panjang gelombang 585 nm dengan operating time pada menit ke-29 dan menit ke-30 menggunakan pereaksi Schiff. Hasil analisis menunjukkan bahwa kadar formaldehida yang terdapat dalam beberapa daging olahan yang beredar dipasar tradisional memiliki kadar (0,3050 ± 0,0241 µg/g) dan (0,6543 ± 3,2353 µg/g). Dari hasil penelitian dapat disimpulkan bahwa beberapa daging olahan yang beredar di pasar tradisional mengandung formaldehid.   Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/96 10.36490/journal-jps.com.v5i1.96 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 108-112 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/96/76 Copyright (c) 2022 syarifah nadia maulina, Ernawati Ginting http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/99 2022-08-09T23:16:02Z jps:ART driver

In silico study of compounds in sea cucumber as an imunomodulator Studi In Silico Senyawa Dalam Teripang Sebagai Imunomodulator Siagian, Josafin Immanuel Purnomo, Hari Sasmito, Ediati An immunomodulator is used to normalize body conditions when the immune system is getting weaker. It is believed that sea cucumbers can increase endurance, improve the immune system, increase disease resistance, reduce chronic fatigue syndrome, and reduce stress. This is an experimental study, conducted in in-silico through molecular docking by using the PLANTS application. This study aimed to examine the structures of Holotoxins A and Cucumarioside A2-2 compounds that were broken down into some sea-cucumbers structures, including a non-sugar Stichopus japonicus, a non-sugar Cucumaria japonica, 3 sugar units of Stichopus japonicus, 3 sugar units of Cucumaria japonica, 6 sugar units of Stichopus japonicus, and 5 sugar units of Cucumaria japonica. Further, this study intended to find out the effectiveness of these structures as immunomodulators and their bioinformatics study. Routine and levamisole were used as a comparison. The code of receptor protein used was 5UO1 on the PDB. In the comparison of positive control of Rutin, several tested compounds have a same effect when compared to Rutin.  These compounds included  3 sugar units of Stichopus japonicus with a calculated value of 2,37, and 3 sugar units of Cucucmaria japonica with a calculated value of 0,37. The resulting value of the three compounds was T-count < T-table. Hence, there was a meaningful not difference between the three compounds and Rutin as an immunomodulatory medicine Penggunaan imunomodulator digunakan pada keadaan tubuh yang sistem imunnya turun dengan harapan kembali normal. Teripang dipercaya dapat meningkatkan daya tahan tubuh, memperbaiki sistem kekebalan, meningkatkan ketahan terhadap penyakit, merendahkan sindrom kelelahan kronis, dan dapat menurunkan stres. Desain Penelitian ini bersifat eksperimental dengan pengujian secara In Silico dengan molecular docking menggunakan aplikasi PLANTS. Tujuan dari penelitian menguji senyawa Holotoxins A dan Cucumarioside A2-2 yang strukturnya dipecah kembali menjadi struktur non gula teripang Stichopus japonicus, non gula teripang Cucumaria japonica, 3 gula teripang Stichopus japonicus, 3 gula teripang Cucumaria japonica, 6 gula teripang Stichopus japonicus, 5 gula teripang Cucumaria japonica untuk dilihat efektivitasnya sebagai imunomodulator serta kajian bioinformatikanya, sebagai pembanding digunakan rutin dan levamisol. Protein reseptor yang digunakan dengan kode 5UO1 pada PDB. Pada perbandingan kontrol positif Rutin, ada beberapa senyawa uji yang memiliki efektivitas sama baiknya apabila dibandingkan dengan Rutin, adapun senyawanya yaitu senyawa 3 gula teripang Stichopus japonicus dengan nilai Thitung 2,37 dan senyawa 3 gula teripang Cucumaria japonica dengan nilai Thitung 0,37. Kedua senyawa memiliki nilai Thitung < Ttabel sesehingga tidak ada perbedaan bermakna antara kedua senyawa dan rutin sebagai obat imunomodulator Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/99 10.36490/journal-jps.com.v5i1.99 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 33-41 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/99/68 Copyright (c) 2022 Josafin Immanuel Siagian, Hari Purnomo, Ediati Sasmito http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/100 2022-08-09T23:16:02Z jps:ART driver

FORMULATION AND EVALUATION OF SHEET MASK CONTAINING GREEN APPLE FRUIT (Malus domestica) EXTRACT AS ANTIOXIDANT FORMULASI DAN EVALUASI SEDIAAN MASKER SHEET MENGANDUNG EKSTRAK BUAH APEL HIJAU (Malus domestica) SEBAGAI ANTIOKSIDAN Athaillah, Athaillah Sitorus, Anisa Safira Rambe, Robiatun Pangondean, Aswan Chandra, Putra Green apples (Malus domestica) contain antioxidants which are very good for skin health. Skin is the most important part of the body that needs to be considered in skin beauty. An understanding of the anatomy and physiology about the skin will help facilitate skin care to get fresh, moist, smooth, supple and clean facial skin. The purpose determined the green apple peel extraction (Malus domestica) can be formulated as a sheet mask preparation and to determine the antioxidant test content of the green apple peel extraction with sheet mask (Malus domestica). The extraction method used is the maceration method with 70% ethanol as solvent. The green apple extraction with sheet mask formula is glycerin, butylene glycol, PEG Hydrogenate catsoroil, Xanthan gum, Nipagin, 70% ethanol, Parfum, Aquades and variations of apple fruit extract 2, 4, 6, 8, and 10% (w/v). Evaluation of the preparations carried out was homogeneity, stability, organoleptic test, measurement of pH, and antioxidant content using the DPPH (2,2-diphenyl-1-picrylhydrazil) method. The results show the concentration of green apple peel extraction (Malus domestica) was homogeneous and stable. The result of the pH test which is below the skin limit is F5, pH is 4, so F4 ​​is used as the optimum formula because it has the highest extract content. The results of the antioxidant activity test obtained an IC50 value of 128.09 ppm with a medium level category. Buah  apel  hijau (Malus domestica) mengandung senyawa antioksidan yang bagus dalam menjaga Kesehatan kulit. Kulit adalah bagian tubuh yang paling penting untuk diperhatikan dalam hal kecantikan kulit. Memahami anatomi dan fisiologi dari kulit memudahkan perawatan kulit untuk menjaga kulit wajah tetap segar, lembab, halus, kenyal dan bersih. Tujuan dari penelitian adalah untuk mengetahui apakah hasil ekstraksi kulit buah apel hijau (Malus domestica) dapat diformulasikan sebagai sediaan masker sheet serta mengetahui kandungan uji antioksidan pada masker sheet ekstrak kulit buah apel hijau (Malus domestica). Ekstrak diperoleh dengan cara metode maserasi menggunakan larutan etanol 70% sebagai pelarut. Formula masker sheet ekstrak buah apel hijau adalah gliserin, butilen glikol, PEG Hydrogenate catsoroil, Xanthan gum, Nipagin, Etanol 70%, Parfum, Aquades dan variasi ekstrak buah apel 2, 4, 6, 8, dan 10 % (b/v). Evaluasi sediaan yang dilakukan adalah uji homogenitas, stabilitas, organoleptis, pengukuran pH, dan kandungan antioksidan dengan metode DPPH (2,2-difenil-1-pikrilhidrazil). Hasil penelitian menunjukkan konsentrasi sediaan ekstrak kulit buah apel hijau (Malus domestica) homogen dan stabil. Hasil uji pH yang berada di bawah batas kulit adalah F5 yaitu pH 4, sehingga F4 digunakan sebagai sediaan optimum dengan kandungan ekstrak tertinggi. Hasil pengujian aktivitas antioksidan diperoleh nilai IC50 sebesar 128.09 ppm dengan kategori tingkat sedang. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/100 10.36490/journal-jps.com.v5i1.100 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 54-61 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/100/69 Copyright (c) 2022 Athaillah Athaillah, Anisa Safira Sitorus, Robiatun Rambe, Aswan Pangondean, Putra Chandra http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/101 2022-08-09T23:16:02Z jps:ART driver

DETERMINATION OF S-ALLYL CYSTEINE (SAC) COMPOUNDS IN SOLO BLACK GARLIC EXTRACT BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY PENETAPAN KADAR SENYAWA S-ALLYL CYSTEINE (SAC) PADA EKSTRAK SOLO BLACK GARLIC SECARA KROMATOGRAFI CAIR KINERJA TINGGI Romsiah, Romsiah Ayu, Jeshi Gecka Fatoni, Ahmad The research has been regarding of method validation and determination S-allyl cisteine coumpound from solo black garlic extract by high perfomance liquid chromatography. The stationary phase used is ODS C-18 and the mobile phase is acetonitril : aquabidest (50:50 v/v) at a flow rate of 1,0 ml/min and detected at wavelength 195 nm for S-allyl cysteine. Before determination should be qualitative test determinant a maximum wavelength of sample. Standard solution S-allyl cysteine (SAC) with concentration 50, 100, 150, and 200 ppm wich is measured at a maximum wavelength of 195 nm, the value of regression line equation is y = 4,818x + 46,5 with the value of the correlation coefficient is (r) = 0,998. Obtained result sample wavelength 194 nm near to maximum wavelength of standard solution. The result of determination solo black garlic extract show for solo black garlic extract contain S-allyl cysteine 52,055 % with category high antioxidant activity 50-90 %. Based on the result it can be concluded that a HPLC is valid and the sample solo black garlic still show high S-allyl cysteine coumpound.  Telah dilakukan penelitian mengenai penetapan kadar senyawa S-allyl sistein pada ekstrak solo black garlic secara kromatografi cair kinerja tinggi. Fase diam yang digunakan yaitu ODS C-18 dan fase gerak asetonitril : aquabidest (50:50 v/v) pada laju alir 1,0 ml/menit dengan panjang gelombang 195 nm untuk S-allil sistein. Sebelum melakukan penetapan kadar harus dilakukan uji kualitatif penentuan panjang gelombang pada sampel. Larutan baku standar S-allyl sistein dengan konsentrasi 50, 100, 150, dan 200 ppm yang diukur pada panjang gelombang maksimum 195 nm didapatkan nilai persamaan garis regresi y = 4,818x + 46,5 dengan nilai koefisien relasi (r) = 0,998. Diperoleh hasil panjang gelombang sampel 194 nm mendekati panjang gelombang maksimum pada baku standar. Hasil penetapan kadar dalam ekstrak solo black garlic menunjukkan hasil yaitu pada sampel ekstrak solo black garlic mengandung kadar S-allil sistein 52,055 % dengan kategori aktivitas antioksidan tinggi 50-90 %. Berdasarkan hasil penelitian dapat disimpulkan bahwa metode KCKT pada sampel solo black garlic masih menunjukkan adanya senyawa S-allil sistein yang tinggi. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/101 10.36490/journal-jps.com.v5i1.101 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 74-80 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/101/71 Copyright (c) 2022 Romsiah, Jeshi Gecka Ayu, Ahmad Fatoni http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/102 2022-08-09T23:16:02Z jps:ART driver

THE DESCRIPTION OF K3RS PROGRAM IMPLEMENTATION IN NORTH SUMATERA LUNG HOSPITAL GAMBARAN PELAKSANAAN PROGRAM K3RS DI UPT. RSK PARU PROVINSI SUMATERA UTARA Sinuraya, Laura Natalia Christin Hospital is one of the workplaces of the healthcare sector which includes many aspects and human resources which are certainly at risk of causing occupational disease and work accidents. North Sumatera Lung Hospital is one of the high risk hospital, therefore the implementation of health and safety (K3RS)  programs is essential. This study aims to describe the health and safety programs at North Sumatera Lung Hospital. This study used a cross sectional approach which samples were 35 employees taken by using random sampling method. The results of this study indicate that the implementation of the health and safety programs at North Sumatera Lung Hospital consists of occuoational health and  safety programs. The program has been implemented but has not been maximized because there are still sub-programs that have not been running effectively. The conclusion of this study is the programs has been implemented, but there are still need a program development and evaluation, so the implementation of the health and safety programs at North Sumatera Lung Hospital can work optimally Rumah sakit adalah salah satu tempat kerja sektor pelayanan kesehatan yang banyak meliputi banyak aspek dan sumber daya manusia yang tentunya berisiko berisiko terjadinya penyakit akibat kerja dan kecelakaan kerja. UPT. RSK Paru Provinsi Sumatera Utara adalah rumah sakit yang berisiko tinggi, sehingga diperlukan pelaksanaan program K3RS. Penelitian ini bertujuan untuk menggambarkan pelaksanaan program K3RS di UPT. RSK Paru Provinsi Sumatera Utara. Penelitian ini menggunakan pendekatan cross sectional. Sampel diambil dengan menggunakan metode random sampling yaitu pengambilan 35 pegawai. Hasil penelitian ini menunjukkan bahwa pelaksanaan program K3RS di UPT. RSK Paru Provinsi Sumatera Utara terdiri dari program kesehatan kerja dan keselamatan kerja. Program K3RS sudah berjalan dengan baik, namun belum maksimal karena masih ada sub program yang belum berjalan dengan efektif. Kesimpulan dari penelitian ini adalah seluruh program K3RS sudah berjalan dan di tinjau ulang setiap tahunnya, namun masih ada sub program yang masih belum efektif, sehingga masih diperlukan pengembangan dan evaluasi program agar pelaksanaan program K3RS di UPT. RSK Paru Provinsi Sumatera Utara dapat berjalan dengan optimal. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/102 10.36490/journal-jps.com.v5i1.102 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 81-85 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/102/72 Copyright (c) 2022 Laura Natalia Christin Sinuraya http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/103 2022-08-09T23:16:02Z jps:ART driver

INSULIN THERAPY COMPLIANCE OVERVIEW OF DIABETES MELLITUS PATIENTS ON AN OUTPATIENT BASIS BAITURRAHIM HOSPITAL YEAR 2022 GAMBARAN KEPATUHAN TERAPI INSULIN PASIEN DIABETES MELITUS DI RAWAT JALAN RUMAH SAKIT BAITURRAHIM TAHUN 2022 Halimatussa'diyah, Halimatussa'diyah Agusriani, Agusriani Pane, Nurul Hidayati Diabetes mellitus is a serious, long-term (or "chronic") condition that occurs when an increase in blood glucose levels occurs because the body cannot produce one or enough of the hormone insulin or cannot use insulin effectively. One way that can be done is to be obedient in undergoing insulin therapy to achieve the success of therapy. The purpose of this study was to determine the picture of insulin therapy compliance of diabetes mellitus patients in the Outpatient Baiturrahim Hospital based on gender, age, and level of education. The type of research carried out is descriptive observational research with a cross-sectional approach model. The sampling technique used Purposive Sampling in 35 patients. The research instrument used was the Morisky Medication Adherence MMAS-8 questionnaire. The results showed that insulin therapy adherence of diabetes mellitus patients in outpatient hospitals had high compliance of 14 patients (40%), moderate adherence of 11 patients (31%), and low compliance of 10 patients (29%). Diabetes melitus adalah kondisi serius, jangka panjang (atau “kronis”) yang terjadi ketika peningkatan kadar glukosa darah terjadi karena tubuh tidak dapat memproduksi salah satu atau cukup hormon insulin atau tidak dapat menggunakan insulin secara efektif. Salah satu cara yang dapat dilakukan adalah patuh dalam menjalani terapi insulin agar tercapainya keberhasilan terapi. Tujuan penelitian ini untuk mengetahui gambaran kepatuhan terapi insulin pasien diabetes melitus di Rawat Jalan Rumah Sakit Baiturrahim berdasarkan jenis kelamin, usia, dan tingkat pendidikan. Jenis penelitian yang dilakukan adalah penelitian observasional deskriptif dengan model pendekatan cross sectional. Teknik pengambilan sampel menggunakan Purposive Sampling pada 35 pasien. Instrument penelitian yang digunakan adalah kuesioner Morisky Medication Adherence MMAS-8. Hasil penelitian menunjukkan bahwa kepatuhan terapi insulin pasien diabetes melitus di Rawat Jalan Rumah Sakit Baiturrahim memiliki kepatuhan tinggi sebanyak 14 pasien (40%), kepatuhan sedang sebanyak 11 pasien (31%), kepatuhan rendah sebanyak 10 pasien (29%). Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/103 10.36490/journal-jps.com.v5i1.103 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 113-119 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/103/77 Copyright (c) 2022 Halimatussa'diyah Halimatussa'diyah, Agusriani Agusriani, Nurul Hidayati Pane http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/104 2022-08-09T23:16:02Z jps:ART driver

The Potency Of Extract Karamunting Leaf (Rhodomyrtus Tomentosa) As Analgesic On Mice (Mus Musculus L.) By Chemical Induction Method POTENSI ANALGESIK EKSTRAK ETANOL DAUN KARAMUNTING (Rhodomyrtus tomentosa) PADA MENCIT JANTAN (Mus musculus L.) DENGAN METODE INDUKSI KIMIA Sianturi, Sister Butarbutar, Maria Elvina Tresia Simanjuntak, Servis Karamunting (Rhodomyrtus tomentosa is one of  traditional medicinal plants used for treating headaches. The purpose of this study was to examine the analgetic effect karamunting leaves ethanol exktract. The karamunting leaves  was obtained from the region village Batunabolom Toba samosir, North Sumatra. The extract was Prepared  by macerating karamunting leaves powder in 70% ethanol. The analgesic effect test of karamunting leaves ethanol exktract  was carried out by chemical induction method used 25 male white mice which divided in five treatment groups.  The treatment groups consisted negative control ofCMC 0.5%, positive control of acetosal  1.3 mg / 20g mice body weight andthe karamunting leaves ethanol extract treatment groups with dose variation of 200, 400, and 800 mg/ 20 g mice body weight . The results showed that the karamunting leaves ethanol extract had analgesic effect at 200, 400, and 800 mg / 20 kg mice body weight  withanalgesic strength respectivelly of 46.87%, 54.54%, and 64.20%. Karamunting (Rhodomyrtus tomentosa) merupakan salah satu tanaman yang secara tradisional dimanfaatkan sebagai tanaman obat, seperti mengobati sakit kepala. Tujuan penelitian ini untuk menguji efek analgetik ekstrak etanol daun karamunting diperoleh dari desa Batunabolon,Toba Samosir, Sumatera Utara. Ekstrak dibuat dengan cara maserasi serbuk daun karamunting dalam etanol 70%. uji analgetik ekstrak daun karamunting dilakukan dengan metode induksi kimia pada 25 ekor mencit jantan yang dibagi dalam 5 kelompok perlakuan yaitu kontrol negatif menggunakan CMC 0,5%, kontrol positif diberikan asetosal dengan dosis 1,3 mg/20 g BB mencit dan kelompok perlakuan ekstrak daun karamunting dengan variasi dosis sebesar 200, 400, dan 800 mg/20 kg BB mencit. Hasil penelitian menunjukan bahwa ektrak etanol daun karamunting pada mencit dengan dosis 200, 400, dan 800 mg/20 kg BB mencit mempunyai daya analgetik sebesar 46,87 %, 54,54 %, dan 64,20 %. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/104 10.36490/journal-jps.com.v5i1.104 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 86-93 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/104/73 Copyright (c) 2022 Sister Sianturi, Maria Elvina Tresia Butarbutar, Servis Simanjuntak http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/106 2022-08-09T23:16:02Z jps:ART driver

EVALUATION OF THE LEVEL OF PATIENT SATISFACTION WITH PHARMACEUTICAL SERVICES AT APOTEK X EVALUASI TINGKAT KEPUASAN PASIEN TERHADAP PELAYANAN KEFARMASIAN DI APOTEK X Sinaga, Clara Ritawany Leswana, Nurillahi Febria Diversity and easy access to health enables people to choose health facilities that can provide quality and quality health services. Service quality is related to satisfaction, that is, everything that someone feels. If you want to improve the quality of service, a patient satisfaction level survey is needed. There are five dimensions of service quality to see customer or patient satisfaction known as ServQual. The five dimensions include reliability, responsiveness, assurance, empathy and tangible evidence. This study aims to evaluate customer satisfaction with pharmaceutical services at the AJ Berkah Pharmacy. This research is a non-experimental research type with a descriptive survey design. The research method used is cross sectional. The sampling technique used was purposive sampling. The sample used was 100 patients buying drugs and redeeming drugs at the Apotek X. The results of the measurement of the level of satisfaction are the dimensions of reliability 82,92% responsiveness 83,75% assurance 83,25% empathy 84%, tangible 79,92%. So it can be concluded that the results of the study show the average percentage of score interpretation is 82,77% which means in the category very satisfied. Keberagaman dan kemudahan akses kesehatan menjadikan masyarakat dapat memilih fasilitas kesehatan yang dapat memberikan pelayanan kesehatan yang bermutu dan berkualitas.Jika ingin melakukan peningkatan kualitas pelayanan maka diperlukan survei tingkat kepuasan pasien. Ada lima dimensi kualitas jasa untuk melihat kepuasan konsumen atau pasien yang dikenal dengan nama ServQual. Kelima dimensi tersebut meliputi kehandalan (reliability), ketanggapan (responsiveness), jaminan (assurance), empati (emphaty) dan bukti langsung (tangible). Penelitian ini bertujuan untuk mengevaluasi kepuasan pelanggan terhadap pelayanan kefarmasian di Apotek X. Penelitian ini merupakan jenis penelitian non eksperimen dengan rancangan survei deskriptif. Metode penelitian yang dilakukan yaitu cross sectional. Teknik pengambilan sampel yang dilakukan yaitu purposive sampling. Sampel yang digunakan yaitu 100 pasien membeli obat dan menebus obat di Apotek X.         Hasil dari pengukuran tingkat kepuasan dimensi kehandalan 82,92%, daya tanggap 83,75%, jaminan 83,25%, empati 84%, bukti langsung 79,92%. Maka dapat disimpulkan hasil penelitian menunjukan rata-rata presentase interpretasi skor sebesar 82,77% yang artinya dalam kategori sangat puas.        Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/106 10.36490/journal-jps.com.v5i1.106 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 94-100 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/106/74 Copyright (c) 2022 Clara Ritawany Sinaga, Nurillahi Febria Leswana http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/107 2022-08-09T23:16:02Z jps:ART driver

FORMULATION OF RED BETEL LEAF EXTRACT SERUM (Piper crocatum Ruiz & Pav.) AS ANTIOXIDANT FORMULASI SEDIAAN SERUM EKSTRAK DAUN SIRIH MERAH (Piper crocatum Ruiz & Pav.) SEBAGAI ANTIOKSIDAN Febriani, Yessi salman, salman Lubis, Salmah Handayani Annisa, Fara Red betel leaf (Piper crocatum Ruiz & Pav.) is a plant that has medicinal and cosmetic properties. One of the cosmetics used by society today is facial serum. The purpose of this study was the formulation of facial serum from red betel leaf water extract. The water extract was obtained by means of the Pressurized Hot Water Extraction method using distilled water as a solvent, then phytochemical screening was carried out. Serum is made in several concentrations, namely 1.5% (F1); 2% (F2);3%;(F3) and blank (F0). The quality inspection of the preparation includes homogeneity test, pH, viscosity, stability, irritation test, hedonic test, and antioxidant activity test. The results of phytochemical screening of red betel leaf water extract contained alkaloids, flavonoids, tannins, saponins and triterpenoids. Red betel leaf is formulated into a homogeneous serum preparation with a temporary pH range of 6.1-6.2 after testing has a pH of 5.8-6.1 and does not irritate the skin. The results of the antioxidant activity test showed that the water extract of red betel leaf (Piper crocatum Ruiz & Pav.) was included in the "strong" antioxidant category with an IC50 value of 38.30 g/ml. The IC50 values ​​for serum preparations F0, F1, F2 and F3 were 430.3689 g/ml (weak), 252.03 g/ml (moderate), 115.6 g/ml (moderate) and 58.13 g/ml (strong). Based on this study, it was concluded that all facial serum formulas were homogeneous, stable and did not irritate the skin and serum preparations with 3% red betel leaf water extract (F3) had the best activity in the category of strong antioxidants. Daun sirih merah (Piper crocatum Ruiz & Pav.) merupakan salah satu tanaman yang mempunyai khasiat sebagai obat dan kosmetika. Salah satu kosmetika yang digunakan masyarakat saat ini adalah serum wajah. Tujuan penelitian ini adalah formulasi sediaan serum wajah dari ekstrak air daun sirih merah. Ekstrak air diperoleh dengan cara metode ekstraksi Pressurized Hot Water Extraction menggunakan pelarut  akuades, kemudian dilakukan skrining fitokimia. Serum dibuat dalam beberapa konsentrasi yaitu 1,5% (F1); 2% (F2);3%;(F3) dan blanko (F0). Pemeriksaan mutu sediaan meliputi uji homogenitas, pH, viskositas, stabilitas, uji iritasi, uji hedonik, serta pengujian aktivitas antioksidan. Hasil skrining fitokimia ekstrak air daun sirih merah terdapat senyawa alkaloid, flavonoid, tanin, saponin dan triterpenoid. Daun sirih merah diformulasikan kedalam sediaan serum yang homogen dengan rentang pH sesaat dibuat 6,1-6,2 setelah pengujian memiliki pH 5,8-6,1 dan tidak mengiritasi kulit. Hasil pengujian aktivitas antioksidan menunjukkan bahwa ekstrak air daun sirih merah (Piper crocatumRuiz & Pav.) masuk dalam kategori antioksidan “kuat” dengan nilai IC50 38,30 µg/ml. Nilai IC50 sediaan serum F0, F1, F2 dan F3 berturut turut dengan kategori aktivitasnya adalah  430,3689 µg/ml (lemah), 252,03 µg/ml (sedang) , 115,6 µg/ml ( sedang) dan 58,13 µg/ml (kuat). Berdasarkan penelitian ini disimpulkan bahwa semua formula serum wajah homogen, stabil dan tidak mengiritasi kulit dan sediaan serum dengan  ekstrak air daun sirih merah 3 % (F3) mempunyai aktvitas paling baik dengan kategori antioksidan kuat, Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/107 10.36490/journal-jps.com.v5i1.107 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 120-127 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/107/78 Copyright (c) 2022 Yessi Febriani, salman salman, Salmah Handayani Lubis, Fara Annisa http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/108 2022-08-09T23:16:02Z jps:ART driver

ANTIBACTERIAL ACTIVITY TEST OF BIDARA (Ziziphus mauritiana Lam) ETHANOL EXTRACT ON GROWTH OF Streptococcus mutans UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN BIDARA (Ziziphus mauritiana Lam) TERHADAP PERTUMBUHAN Streptococcus mutans Shufyani, Fahma Dominica, Dwi Streptococcus mutans, one of the normal microflora in the mouth. Bidara leaves have antimicrobial activity against Streptococcus mutans, because bidara leaves contain various compounds including alkaloids, flavonoids, tannins, saponins. This research method is experimental using disc diffusion method. The sample of this study was Streptococcus mutans, the dilution of bidara leaf extract consisted of 4 concentrations, namely: 20%, 40%, 60%, 80%. Amoxicillin was used for positive control. The results showed that the average diameter of the inhibition zone of bidara leaf extract at a concentration of 20% with a diameter of 11.50 mm, at a concentration of 40% and 60% with a diameter of 12.50 mm and 16.06 mm, at a concentration of 80% with a diameter of 17.50mm. The conclusion is that the higher the concentration of bidara leaf extract, the more the inhibition zone formed will increase. So that bidara leaves are good for use in treating infections caused by Streptococcus mutans bacteria. Streptococcus mutans, salah satu mikroflora normal yang berada didalam mulut. Daun bidara mempunyai aktivitas antimikroba terhadap Streptococcus mutans, karena daun bidara mengandung berbagai senyawa diantaranya adalah alkaloid, flavonoid, tannin, saponin. Metode penelitian ini experimental menggunakan metode difusi cakram. Sampel penelitian ini adalah Streptococcus mutans, pengenceran ekstrak daun bidara terdiri dari 4 konsentrasi diantaranya adalah : 20%, 40%, 60%, 80%. Untuk  kontrol positif digunakan amoxicillin. Hasil pengamatan menunjukan bahwa rata-rata diameter zona hambat ekstrak daun bidara pada konsentrasi 20% dengan diameter 11,50 mm, pada konsentrasi 40% dan 60% dengan diameter 12,50 mm dan 16,06 mm, pada konsentrasi 80% dengan diameter 17,50 mm. Kesimpulan bahwa semakin tinggi konsentrasi ekstrak daun bidara maka zona hambat yang terbentuk pun akan semakin meningkat. Sehingga daun bidara baik untuk digunakan dalam mengobati infeksi yang disebabkan bakteri Streptococcus mutans. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/108 10.36490/journal-jps.com.v5i1.108 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 128-135 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/108/79 Copyright (c) 2022 Fahma Shufyani, Dwi Dominica, http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/109 2022-08-09T23:16:02Z jps:ART driver

FORMULATION JELLY CANDY FROM KALIMANSI ORANGE (Citrofotunella microcarpa ) AS AN INCREASE IN BODY ENDURANCE FORMULASI PERMEN JELLY DARI JERUK KALIMANSI (Citrofotunella microcarpa ) SEBAGAI PENINGKATAN DAYA TAHAN TUBUH Dominica, Dwi Shufyani, Fahma Background : In facing a lifestyle during a pandemic, endurance is one of the most important things to keep away from all kinds of diseases. The body's immune system has a very important role to keep the body healthy and able to support various activities. One of the pharmaceutical preparations that can be consumed by both children and adults in binding their immune system is jelly candy which is rich in vitamin C content. against white male mice (Mus musculus). Methodology: the method used in this study was experimental and continued with the swimming test. Results: after testing for 4 weeks on jelly candy, all jelly candy preparations had no significant changes, and after the one-way Anova test showed a significant difference in each group (p<0.5), which was continued by Duncan's test. then FIII with a concentration of 45% kalimansi orange is the best with swimming endurance time after treatment in group F III which consists of 3 data, the average value (mean) is 86.56 (95% CI: 79.77 – 93.35) , the standard deviation is 2.73, the lowest value is 84.10 and the highest value is 89.50. Then continued with FII and FI. Conclusion : Kalimansi orange juice can be made jelly candy and the best formulation of FIII Dalam menghadapi gaya hidup selama pandemic, daya tahan tubuh menjadi salah satu hal yang sangat diperhatikan guna menjauhi segala macam penyakit. Sistem imunitas tubuh memiliki peran yang sangat penting agar tubuh tetap sehat dan mampu menunjang berbagai aktivitas. Salah satu sediaan farmasi yang bisa dikonsumsi baik anak-anak ataupun dewasa dalam mengikatkan daya tahan tubuh adalah permen jelly yang kaya akan kandungan vitamin C. Penelitian ini bertujuan untuk memformulasi sediaan permen jelly dari jeruk kalimansi (Citrofotunella macrocarpa) dan mengetahui efek tonikum dari permen jelly terhadap mencit putih jantan (Mus musculus). Metodologi : metode yang digunakan pada penelitian ini ada experimental dan dilanjutkan uji renang. Hasil : setelah dilakukan pengujian selama 4 minggu terhadap permen jelly maka semua sediaan permen jelly tidak ada perubahan yang signifikan, dan setelah dilakukan pengujian Anova satu arah menunjukkan perbedaan yang bermakna pada masing-masing kelompok (p<0,5), dimana dilanjutkan uji Duncan maka FIII dengan konsentrasi jeruk kalimansi 45% lah yang terbaik dengan waktu ketahanan renang setelah perlakuan kelompok F III yang terdiri dari 3 data diperoleh nilai rata-rata (mean) sebesar 86,56 (95% CI : 79,77 – 93,35), standar deviasi sebesar 2,73, nilai terendah sebesar 84,10 dan nilai tertinggi sebesar 89,50. Kemudian dilanjutkan dengan FII dan FI. Kesimpulan : perasan jeruk kalimansi dapat dibuat permen jelly dan formulasi FIII yang terbaik Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/109 10.36490/journal-jps.com.v5i1.109 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 136-145 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/109/80 Copyright (c) 2022 Dwi Dominica, Fahma Shufyani http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/110 2022-08-09T23:16:02Z jps:ART driver

LITERATURE REVIEW ANALYSIS OF COST EFFECTIVENESS OF ANTIBIOTIC USE IN PEDIATRIC TYPHOID FEVER PATIENTS IN INDONESIA REVIEW : ANALISIS EFEKTIFITAS BIAYA PENGGUNAAN ANTIBIOTIK PADA PASIEN DEMAM TIPHOID ANAK DI INDONESIA Siahaan, Desy Natalia Hasanah, Fenny Dasopang, Eva Sartika Ndruru, Rini Agnesia Indonesia is one of the endemic areas for typhoid fever with the majority of the incidents occurring in the age group 3-19 years (91% cases) (Cammie F. L. 2005; Brusch, J.L.,2010; IDAI, 2008). The high incidence of typhoid fever requires a pharmacoeconomic evaluation to get the best therapy in terms of economic value. One of the methods used is the method of Cost-Effectiveness Analysis. The purpose of this research is to find out which antibiotic has the most cost-effectiveness based on the ACER value obtained from various sources of articles published in 2016- 2021. This method is used related to the current pandemic period were preventing the transmission of COVID-19 activities is increasingly being limited, one of which is avoiding face-to-face meetings in research. The results showed that typhoid fever was more common in boys with an age range of under 12 years. The antibiotics most commonly used are chloramphenicol, thiamphenicol, ceftriaxone, cefixime, cefotaxime, ampicillin, and amoxicillin. The most Cost Effectiveness based on ACER value (Rp. /day free of fever) is Ceftriaxone. Indonesia merupakan salah satu wilayah endemis demam tifoid dengan mayoritas angka kejadian terjadi pada kelompok umur 3-19 tahun (91% kasus) (Cammie F. L.,2005; Brusch, J.L.,2010 IDAI, 2008). Tingginya angka kejadian demam tifoid, memerlukan evaluasi farmakoekonomi untuk mendapatkan terapi yang paling terbaik dari segi nilai ekonomisnya. Salah satu metode yang digunakan adalah metode Analisis Efektitivitas Biaya. Tujuan dari penelitian ini untuk mengetahui Antibiotik yang paling Cost Effectiveness berdasarkan nilai ACER yang diperoleh dari berbagai sumber artikel terbitan tahun 2016-2021. Metode ini digunakan terkait masa pandemic saat ini dimana untuk mencegah penularan COVID-19 kegiatan semakin dibatasi salah satunya dengan menghindari pertemuan tatap muka dalam penelitian. Hasil penelitian menunjukkan bahwa penyakit demam tifoid lebih banyak diderita anak laki-laki dengan rentang usia dibawah 12 tahun. Antibiotik yang paling sering digunakan adalah Kloramfenikol, Tiamfenikol, Seftriakson, Sefiksim, Sefotaksim, Ampisislin dan Amoksilin. Terapi yang paling Cost Effectiveness berdasarkan nilai ACER (Rp./hari bebas demam) adalah Seftriakson. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-06-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/110 10.36490/journal-jps.com.v5i1.110 Journal of Pharmaceutical And Sciences; Vol 5 No 1 (2022): JPS Volume 5 Nomor 1 (2022); 146-155 2656-3088 10.36490/journal-jps.com.v5i1 ind https://www.journal-jps.com/index.php/jps/article/view/110/81 Copyright (c) 2022 Desy Natalia Siahaan, Fenny Hasanah, Eva Sartika Dasopang, Rini Agnesia Ndruru http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/111 2022-08-11T02:54:17Z jps:ART driver

THE EFFECT OF COFFEE LEATHER FERMENTATION BY Aspergillus niger WITH THE ADDITION OF TWO VARIATIONS OF THE CONCENTRATION OF UREA AND AMMONIUM SULPHATE USING TWO FERMENTATION TECHNIQUES ON CRUDE FIBER PENGARUH FERMENTASI TEPUNG KULIT KOPI OLEH Aspergillus niger DENGAN PENAMBAHAN DUA VARIASI KONSENTRASI UREA DAN AMONIUM SULFAT MENGGUNAKAN DUA TEKNIK FERMENTASI TERHADAP SERAT KASAR Salman, Salman Sinaga, Kurniawan Indriana, Meutia Maharani, Sri The volume of waste coffee's extensive remains has not been used optimally by farmers. All the time coffee has skied has just been wasted in the garbage and pollution. Innovation is needed to process waste to be valuable and worthwhile research aims to lose the fermented rough fibres of the coffee (Coffea sp.) using Aspergillus niger mushroom. It is hoped that the research results may be helpful for fodder, fish feed, and prebiotic drink and improve the nutritional value. This study used experimental and crude fibre testing methods using the Wendee method with fermentation times of 24, 48, and 72 hours and placing the fermentation medium in a solid and wet place, observing the growth of fungus test sample was carried out visually. After the fermentation, a crude fibre reduction test was created using The Wendee method. Based on the study results, fermentation of coffee husk flour (Coffea sp.) using Aspergillus niger with urea, ammonium sulphate, and mineral can reduce crude fibre. Differences in fermentation media on wet resulted in decreasing crude fibre than fermentation with solid media. Solid state fermentation of coffee husks can reduce natural fibre at N1 by 0.23 grams (23%) and N2 by 0.21 grams (21%), while on wet media, it results in a decrease in crude fibre by) 0.15 grams (15%). The results showed that the more Aspergillus niger inoculum used, the faster the degradation process of lignocellulose and the more fibres formed. Meanwhile, differences in test media and humidity levels significantly affect the lag-time phase. Volume ampas kopi yang sangat besar belum terolah oleh petani secara optimal. Selama ini kulit kopi hanya terbuang begitu saja menjadi sampah berserakan dan polutan. Inovasi dibutuhkan untuk mengolah limbah kopi agar dapat bermanfaat dan tidak terbuang. Penelitian bertujuan menurunkan serat kasar kulit kopi (Coffea sp.) yang difermentasi menggunakan jamur Aspergillus niger sehingga diharapkan hasil penelitian dapat bermanfaat sebagai bahan pakan ternak, pakan ikan, minuman prebiotik dan meningkatkan mutu nilai nutrisinya. Penelitian dilakukan dengan metode eksperimental, memakai bahan uji tepung kulit kopi (Coffea sp.), jamur Aspergillus niger, urea, amonium sulfat dan mineral. Dengan cara difermentasi pada media padat dan media basah pada suhu kamar selama 24 jam, 48 jam dan 72 jam pengamatan pertumbuhan jamur pada sampel uji dilakukan secara visual. Setelah fermentasi, dilakukan uji penurunan serat kasar pada sampel menggunakan uji metode Wendee. Hasil penelitian menunjukkan bahwa fermentasi tepung kulit kopi (Coffea sp.) menggunakan Aspergillus niger dengan penambahan urea, amonium sulfat dan mineral dapat menurunkan jumlah serat kasar. Perbedaan media fermentasi menunjukkan bahwa fermentasi pada media basah memberikan hasil penurunan serat kasar yang lebih baik dibandingkan fermentasi pada media padat. Hasil serat kasar pada N1 sebesar 0,23 gram (23%) dan pada N2 sebesar 0,21 gram (21%), sedangkan hasil serat kasar pada media basah sebesar 0,15 gram (15%). Hasil penelitian menunjukkan semakin banyak inokulum Aspergillus niger yang dipakai maka, mempercepat proses degradasi lignoselulosa dan serat yang terbentuk semakin banyak. Sedangkan perbedaan media uji dan tingkat kelembapan sangat mempengaruhi fase lag-time. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-07-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/111 10.36490/journal-jps.com.v5i2.111 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 156-169 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/111/82 Copyright (c) 2022 Salman Salman, Kurniawan Sinaga, Meutia Indriana, Sri Maharani http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/112 2022-08-10T19:37:55Z jps:ART driver

Identification Retinoic Acid Content in Online Whitening Cream Sold in Samarinda City Using Thin Layer Chromatography (TLC) and Spectrophotometry UV-Visible Methods Identifikasi Kandungan Asam Retinoat pada Krim Pemutih yang diperjual Belikan Secara Online di Kota Samarinda dengan Metode Kromatografi Lapis Tipis dan Spektrofotometri UV-Visible Leswana, Nurillahi Febria Sinaga, Clara Ritawany Whitening creams are cosmetic preparations that are very often traded in the market because they are able to reduce skin brightness and black spot on the face. Whitening creams can contain chemicals that are harmful to the skin, such as, mercury, hydroquinone, and retinoic acid. Retinoic acid is prohibited from being used in whitening creams because it can cause dry, burning, and teratogenic (defects in the fetus) skin. The purpose of this study was to identify whether the whitening creams traded online in Samarinda City contained retinoic acid and to determine the level of retinoic acid in the face whitening cream. The samples studied were 5 samples each of sample A, sample B, sample C, sample D, and sample E. Qualitative analysis was carried out by the thin layer chromatography method using the n-hexane-acetone (6:4) and observed under 254 nm UV light. Based on qualitative analysis, sample B and Sample D were positive containing retinoic acid with rf values of sample B (Rf 0.48), sample D (Rf 0.47). The results of quantitative analysis using UV Visible spectrophotometry showed that all five samples contained retinoic acid with levels of 0.003%-0.024%. Krim pemutih adalah sediaan kosmetika yang sering diperjual belikan di pasaran karena dapat mengembalikan kecerahan kulit juga mengurangi warna hitam pada wajah. Krim pemutih dapat mengandung bahan kimia yang berbahaya bagi kulit, seperti, merkuri, hidrokuinon, dan asam retinoat. Asam retinoat dilarang digunakan dalam krim pemutih karena dapat menyebabkan kulit kering, rasa terbakar, dan teratogenik (cacat pada janin). Tujuan penelitian ini adalah mengidentifikasi apakah krim pemutih yang diperjual belikan secara online di Kota Samarinda mengandung asam retinoat dan untuk mengetahui kadar asam retinoat dalam krim pemutih wajah tersebut. Sampel yang diteliti adalah 5 sampel masing-masing sampel A, sampel B, sampel C, sampel D, dan sampel E. Analisis kualitatif dilakukan dengan metode kromatografi lapis tipis menggunakan fase gerak n-heksan-aseton (6:4) dan diamati di bawah sinar UV 254 nm. Berdasarkan analisis kualitatif diperoleh sampel B dan Sampel D positif mengandung asam retinoat dengan nilai Rf sampel B (Rf 0,48), sampel D (Rf 0,47). Hasil analisis kuantitatif menggunakan spektrofotometri UV Visible menunjukkan bahwa kelima sampel mengandung asam retinoat dengan kadar 0,003%-0,024% . Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-07-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/112 10.36490/journal-jps.com.v5i2.112 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 174-180 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/112/84 Copyright (c) 2022 Nurillahi Febria Leswana, Clara Ritawany Sinaga http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/113 2022-08-10T19:37:55Z jps:ART driver

THE QUALITY OF LIFE IN FEMALES WITH DIABETES MELLITUS GAMBARAN KUALITAS HIDUP PADA WANITA DENGAN DIABETES MELLITUS Rahmawati, Reza Nurlita, Septia Putri Widiyati, Eni Latar belakang: Salah satu tujuan utama dalam terapi pengobatan adalah untuk memperbaiki kualitas hidup pasien. Kebanyakan pasien diabetes mellitus memiliki kualitas hidup yang rendah terutama pada pasien Wanita. Oleh karena itu, penelitian ini bertujuan untuk mengidentifikasi gambaran kualitas hidup pasien wanita dengan diabetes mellitus.  Metodologi: Penelitian dilakukan secara deskriptif dan cross sectional. Metode pengambilan sampel dilakukan secara accidental sampling pada responden yang memenuhi kriteria inklusi penelitian. Gambaran kualitas hidup diukur menggunakan kuisioner WHOQOL-BREF yang terdiri dari 26 buah pertanyaan. Hasil:  Dalam penelitian ini diperoleh sampel sebesar 58 orang responden wanita dengan diabetes mellitus. Sebagian besar responden berusia 41-60 tahun (60,34%), menderita diabetes mellitus selama < 5 tahun (58,62%), dan tanpa komplikasi (67,24%). Hasil gambaran kualitas hidup responden sebagian besar memiliki kualitas hidup sedang sebanyak 38%, kualitas hidup buruk sebanyak 34%, kualitas hidup baik sebanyak 24%, dan kualitas hidup sangat baik sebesar 4%. Kesimpulan: Gambaran kualitas hidup pada wanita dengan diabetes mellitus adalah sedang. Background: The main goal of therapeutic treatment is improved the patient quality of life. Most diabetes mellitus patient have low quality of life especially in female. Therefore this study aims to identify the quality of life among female with diabetes mellitus. Methodology: the method of this sudy was descriptive and cross sectional. Respondent who meets inclusion criteria were included in this study. Quality of life were analyzed using WHOQOL-BREF questionnaire. Results: there were 58 female respondent include in this study. Majority of female respondent were 41-60 years old (60,34%), diagnosed with diabetes mellitus for less than 5 years (58,62%) with no complication (67,24%). According to WHOQOL-BREF questionnaire majority female respondent have moderate quality of life (38%), followed by low quality of life (34%), good quality of life (24%) and very good quality of life (4%). Conclusion: Majority of female respondent with diabetes mellitus have moderate quality of life. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-07-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/113 10.36490/journal-jps.com.v5i2.113 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 170-173 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/113/83 Copyright (c) 2022 Reza Rahmawati, Septia Putri Nurlita, Eni Widiyati http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/114 2022-08-10T19:41:55Z jps:ART driver

HEDONIC TEST AND pH EVALUATION OF JELLY CANDY FROM KALAMANSI (Citrofortunella microcarpa) EVALUASI UJI HEDONIK DAN UJI pH SEDIAAN PERMEN JELLY JERUK KALAMANSI (Citrofortunella microcarpa) Sari, Delia Komala dominica, dwi Background : Kalamansi (Citrofortunella microcarpa) is one of the agricultural commodities that has been widely developed in Bengkulu Province. Kalimansi which contain high levels of Vitamin C of 3.863 mg/100 g but have a sour taste so that they are not good for direct consumption. This prompted researchers to make Kalamansi in the form of jelly candy which is one type of product that is favored by various ages, especially children. This study aims to evaluate the pH and perform a hedonic test on the preparation of kalamansi jelly candy. The methodology used in this study is experimental. The pH test results on the 3 formulas obtained that the pH of the preparations was 3.6 (F1), 3.4 (F2) and 3.7 (F3). The hedonic test on the three formulas tested on 10 panelists showed the hedonic value of the dosage form, respectively, namely F1 (76%), F2 (84%) and F3 (70%); color hedonic test F1(70%), F2 (84%) and F3 (74%); taste hedonic test F1 (82%), F2 (86%); and F3 (66%) and texture hedonic test F1 (80%), F2 (90%) and F3 (68%). The conclusion of the hedonic evaluation of the Kalamansi jelly candy preparation showed that F2 was the most preferred with a pH value of 3.2. Jeruk Kalamansi (Citrofortunella microcarpa) merupakan salah satu komoditi pertanian yang telah banyak dikembangkan di Provinsi Bengkulu. Jeruk Kalimansi yang mengandung kadar Vitamin C tinggi sebesar 3,863 mg/100 g namun memiliki rasa yang asam sehingga kurang enak dikonsumsi langsung. Hal ini mendorong peneliti untuk membuat Jeruk Kalamansi dalam bentuk permen jelly yang merupakan salah satu jenis produk yang digemari oleh berbagai kalangan usia, khususnya anak-anak. Penelitian ini bertujuan untuk mengevaluasi pH dan melakukan uji hedonik terhadap sediaan permen jelly jeruk kalamansi. Metodologi yang digunakan pada penelitian ini adalah experimental. Hasil pengujian pH pada 3 formula diperoleh pH sediaan berturut – turut  yaitu 3,6 (F1), 3,4 (F2) dan 3,7 (F3). Uji hedonic pada ketiga formula yang diujikan kepada 10 orang panelis menunjukkan nilai hedonic bentuk sediaan berturut – turut yaitu F1 (76%), F2 (84%) dan F3 (70%); uji hedonik warna F1(70%), F2 (84%) dan F3 (74%); uji hedonic   rasa F1 (82%), F2 (86%), dan F3 (66%) dan uji hedonic tekstur F1 (80%), F2(90%) dan F3 (68%). Kesimpulan hasil evaluasi hedonic sediaan permen jelly jeruk kalamansi menunjukkan F2 paling disukai dengan nilai pH 3,2. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-07-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/114 10.36490/journal-jps.com.v5i2.114 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 181-186 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/114/85 Copyright (c) 2022 Delia Komala Sari, Dwi Dominica http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/115 2022-08-11T22:21:00Z jps:ART driver

PROFILE OF USE OF ANTIPSYCHOTIC MEDICINES IN PATIENTS WITH MENTAL DISORDERS AT UPT. PUSKESMAS HELVETIA CITY OF MEDAN PROFIL PENGGUNAAN OBAT ANTIPSIKOTIK PADA PASIEN ORANG DENGAN GANGGUAN JIWA (ODGJ) DI UPT. PUSKESMAS HELVETIA KOTA MEDAN Surbakti, Cristica Ilsanna Sinaga, Tetty Agustinar Sianipar, Artha Y. Schizophrenia is one of the psychosis disorders that mess with a person's psyche in the form of deviations in attitudes, thoughts, and behaviors. One treatment of schizophrenia is pharmacological therapy using antipsychotics to cope with symptoms that arise. The study aimed to find out the profile of antipsychotic use in schizophrenia patients in UPT. Puskesmas Helvetia Kota Medan. This research was conducted with cross-sectional descriptive methods. Method of data collection by collecting medical record data of patients with schizophrenia diagnoses who received typical and atypical antipsychotic therapy and who sought treatment at UPT. Puskesmas Helvetia Kota Medan period January 2021-June 2021 which meets the criteria of inclusion in the form of patient identity (gender, age). The number of study subjects was 204 patients. The results of the study based on characteristics of schizophrenia patients showed the number of male patients was 123 (60.3%)) more than women (81 patients (39.7%). The age group of patients in the adult age group of 36- 45 years is 45.1%. The most common antipsychotic uses were the single atypical antipsychotic group of risperidone in as many as 20 patients [9.8%], and clozapine 1 patient (0.5%). The most widely used combination antipsychotic group is the atypical antipsychotic risperidone-clozapine of 147 patients (72 %). The conclusion of the picture of the most antipsychotic use is the atypical antipsychotic group. Skizofrenia merupakan salah satu gangguan psikosis yang mengacaukan kejiwaan seseorang berupa penyimpangan sikap, pikiran, dan perilaku. Salah satu penanganan skizofrenia adalah dengan terapi farmakologi menggunakan antipsikotik untuk mengatasi gejala yang timbul. Penelitian ini bertujuan untuk mengetahui profil penggunaan antipsikotik pada pasien skizofrenia di UPT. Puskesmas Helvetia Kota Medan. Penelitian ini dilakukan dengan metode deskriptif cross sectional. Metode pengumpulan data dengan cara mengumpulkan data rekam medik pasien dengan diagnosa Skizofrenia yang mendapat terapi antipsikotik tipikal dan atipikal yang berobat di UPT. Puskesmas Helvetia Kota Medan periode Januari 2021-Juni 2021 yang memenuhi kriteria inklusi berupa identitas pasien (jenis kelamin, umur). Jumlah subjek penelitian adalah 204 pasien. Hasil penelitian berdasarkan karakteristik pada pasien skizofrenia menunjukan jumlah pasien laki-laki 123 (60,3%) lebih banyak dibandingkan perempuan 81 pasien (39,7 %). Kelompok usia pasien terbanyak pada kelompok usia dewasa 36 – 45 tahun yaitu sebesar 45,1%. Penggunaan antipsikotik terbanyak adalah golongan antipsikotik atipikal tunggal risperidone sebanyak 20 pasien [9,8%], clozapine 1 pasien (0,5%). Dan antipsikotik kombinasi yang paling banyak digunakan adalah golongan antipsikotik atipikal yaitu risperidone- clozapin sebanyak 147 pasien [72 %]. Kesimpulan dari gambaran penggunaan antipsikotik terbanyak adalah golongan antipsikotik atipikal. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-07-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/115 10.36490/journal-jps.com.v5i2.115 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 187-192 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/115/86 Copyright (c) 2022 Christica Ilsanna Surbakti, Tetty Agustinar Sinaga, Artha Y. Sianipar http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/117 2022-11-28T23:45:46Z jps:ART driver

Inhibitory Test of Ointment Kalanchoe pinnata leaf Extract And Aloe vera Extract Agusriani, Agusriani Halimatussa'diyah, Halimatussa'diyah Research that uses a combination of two plants is still very rarely done here, researchers are interested in conducting tests to see how the inhibitory ability of the ointment combination of Kalanchoe pinnata leaf extract (Kalanchoe pinnata) and aloe vera leaf extract (Aloe vera) is grown and cultivated in the yard of the Department of Pharmacy, Poltekkes, Ministry of Health. Jambi. The research design used is Quasy Experimental research, that is, this design has control, but cannot function fully to control external variables that affect the experiment. This study uses the Disc Diffusion method. Where it is known that the combination of Kalanchoe pinnata leaf extract ointment and Aloe Vera (Aloe Vera .L.) leaf extract obtained an average measurement of the clear zone of Staphylococcus aureus bacteria with a percentage of F1 is 29.6 mm, F2 is 30.2 mm, F3 is 30.8 , F4 is 31.6 and F5 is 33.8 mm. The different methods can affect the optimization of the withdrawal of the active substance in the leaves of Kalanchoe pinnata and Aloe Vera leaf obtained. So it can be concluded that the combination of Kalanchoe pinnata leaf extract and Aloe Vera leaf extract has an inhibitory effect on Staphylococcus Aureus bacteria. The best formula for the formula is F5 with an inhibition zone of 33.8 mm, which is categorized as very strong. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-11-20 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/117 10.36490/journal-jps.com.v5i2.117 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 240-249 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/117/93 Copyright (c) 2022 Agusriani, Halimatussa’diyah http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/118 2023-06-22T01:16:55Z jps:ART driver

PREPARATION AND CHARACTERIZATION SUBMICRO PARTICLE CHITOSAN AND ALGINATE SODIUM AS CAPTOPRIL BARRIER WITH CHITOSAN VARIATION PREPARASI DAN KARAKTERISASI SUBMIKRO PARTIKEL KITOSAN DAN NATRIUM ALGINAT SEBAGAI PEMBAWA CAPTOPRIL DENGAN VARIASI KITOSAN Wahyuni, Yenni Sri Melinda, Risya Rasyad, Ade Arinia Research has been carried out on submicroparticles of chitosan and sodium alginate as captopril carriers. This study aims to overcome the problem of permeability and improve the absorption of a macromolecular compound. Captopril preparation into submicroparticles with chitosan adsorption polymer, sodium alginate and CaCl2 crosslinking by ionic gelation method can improve the permeability problem of captopril. The concentration of chitosan which was varied against the three formulas was 0.1%; 0.2% and 0.3% resulted in the percent entrapment efficiency (EE) of 69.69% ± 0.292, 76.86% ± 0.535, and 79.26% ± 0.178, respectively. The results of the submicroparticle characterization of each formula such as diameter, particle distribution (PDI) and zeta potential using a particle size analyzer (PSA) were 232.0 nm; 0.259; -29.1 mV (F1), 333.8 nm; 0.290; +32.4 mV (F2), and 426.3 nm; 0.321; +55.6 mV (F3). The best captopril submicro particle formula was achieved in formula 3 (chitosan 0.3%). The polymer concentration has an important influence on the percent entrapment efficiency (EE), particle size, particle distribution, and the zeta potential of the captopril submicroparticles. Telah dilakukan penelitian mengenai submikro partikel kitosan dan natrium alginat sebagai pembawa kaptopril. Penelitian ini bertujuan untuk mengatasi permasalahan permeabilitas dan memperbaiki absorbsi suatu senyawa makromolekul. Preparasi kaptopril menjadi submikro pertikel dengan polimer penjerap kitosan, natrium alginat dan crosslinking CaCl2 dengan metode gelasi ionik dapat memperbaiki masalah permeabilitas kaptopril. Konsentrasi kitosan yang divariasikan terhadap formula F1, F2 dan F3 berturut-turut adalah 0,1%; 0,2% dan 0,3% menghasilkan persen entrapment efficiency (EE) masing-masing sebesar 69,69%; 76,86% dan 79,2%, distribusi partikel (PDI) dan zeta potensial yaitu 232,0 nm; 0,259; -29,1 mV (F1), 333,8 nm; 0,290; +32,4 mV (F2), dan 426,3 nm; 0,321; +55,6 mV (F3).  Formula submikro partikel dapat diperoleh pada formula 3 (kitosan 0,3%). Konsentrasi polimer mempunyai pengaruh penting terhadap persen entrapment efficiency (EE), ukuran pertikel, distribusi partikel, dan zeta potensial dari submikro partikel captopril. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-12-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/118 10.36490/journal-jps.com.v5i2.118 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 409-146 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/118/114 Copyright (c) 2022 Yenni Sri Wahyuni, Risya Melinda, Ade Arinia Rasyad http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/119 2022-08-24T08:16:55Z jps:ART driver

FACTORS RELATING TO DIET IN IMPLEMENTING DIET IN DIABETES MELLITUS PATIENTS IN THE ERA OF THE COVID 19 PANDEMIC IN PANTAI GEMI VILLAGE FAKTOR-FAKTOR YANG BERHUBUNGAN POLA MAKAN DALAM MELAKSANAKAN DIET PADA PASIEN DIABETES MELLITUS DI ERA PANDEMI COVID 19 DI DESA PANTAI GEMI Mulidan, Mulidan Kaban, Ani Rahmadhani Lubis, Afina Muharani Syaftriani Bakti, Agus Surya Diabetes mellitus type 2 is a degenerative disease that is closely related to diet. A diet that has an overview of the amount, composition, and types of food eaten by each person a day. High knowledge will improve the health status of patients by carrying out appropriate treatment according to the patient's condition, if family support is not available then DM patients do not adhere to their diet if family support is good then DM patients will adhere to their diet. Factors related to diet in carrying out the diet of patients with type 2 diabetes mellitus inpatients in Pantai Gemi Village. This research is an analytic observational with a Cross Sectional approach. Sampling technique using Accidental Sampling. Data analysis in this study consisted of univariate and bivariate data analysis using the chi-square test. The sample population is 60 people. The sample is 53 people. Dietary regulation in patients with type 2 diabetes mellitus can improve health status with the presence of health workers, patients can avoid complications. Penyakit diabetes mellitus tipe 2 penyakit degeneratif yang sangat berkaitan dengan pola makan. Pola makan yang mempunyai gambaran mengenai jumlah, komposisi, macam-macam makanan yang dimakan sehari oleh setiap orang. Pengetahuan yang tinggi akan meningkatkan derajat kesehatan bagi pasien dengan melaksanakan perawatan yang tepat sesuai dengan kondisi pasien, jika dukungan keluarga tidak ada maka pasien DM tidak patuh menjalankan dietnya apabia dukungan keluarga baik maka pasien DM akan patuh menjalankan dietnya.Tujuan penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan pola makan dalam melaksanakan diet pasien diabetes mellitus tipe 2 rawat di Desa Pantai Gemi. Penelitian ini bersifat analitik observasional dengan pendekatan Cross Sectional. Teknik pengambilan sampel dengan menggunakan Accidental Sampling. Analisis data dalam penelitian ini terdiri dari analisis data univariat dan bivariat dengan menggunakan Uji Chi-Square. Populasi sampel sebanyak 60 orang. Sampel sebanyak 53 orang. Pengaturan pola makan pada pasien diabetes melitus tipe 2 dapat meningkatkan derajat kesehatan dengan adanya tenaga kesehatan pasien dapat menghindari untuk terjadinya komplikasi. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-07-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/119 10.36490/journal-jps.com.v5i2.119 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 193-200 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/119/87 Copyright (c) 2022 Mulidan Mulidan, Ani Rahmadhani Kaban, Afina Muharani Syaftriani Lubis, Agus Surya Bakti http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/120 2022-08-24T23:56:02Z jps:ART driver

FAMILY SUPPORT WITH MEDICINE COMPLIANCE IN PSYCHONEUROTIC PATIENTS DUKUNGAN KELUARGA DENGAN KEPATUHAN MINUM OBAT PADA PASIEN JIWA Butarbutar, Maria Haryanti Lasmawanti, Sri Purba, Ingkai Krisdayanti Bangun, Herianto Health is an important part of human life, because if the body is healthy then a person can live a productive and quality life. This study aims to determine the relationship between family support and medication adherence in mental patients in mental hospitals. This study uses an analytical survey research design with a cross-sectional approach, using the chi-square test. The population in this study was all families of schizophrenic patients, totaling 118 respondents. The sample used was accidental sampling with as many as 54 respondents. The type of data used is primary data. The data analysis used is the univariate analysis and bivariate analysis. The results showed that there was a relationship between family support and medication adherence in mental patients (p-value = 0.001) The conclusion of this study is that there is a relationship between family support and medication adherence in mental patients in mental hospitals. It is hoped that the patient's family always pays attention to accuracy and compliance in giving medication and can be used as input and information to the family, that family support is important to improve medication adherence in mental patients at the Bina Karsa Mental Hospital. Kesehatan merupakan bagian yang penting bagi kehidupan manusia, karena bila tubuh sehat maka seseoarang dapat menjalani kehidupan secara produktif dan berkualitas. Penelitian ini bertujuan untuk mengetahui hubungan dukungan keluarga dengan kepatuhan minum obat pada pasien jiwa di rumah sakit jiwa. Penelitian ini menggunakan desain penelitian survey analitik dengan pendekatan cross sectional, menggunakan uji chi-square. Populasi dalam penelitian ini adalah semua keluarga pasien skizofrenia yang berjumlah 118 responden. Sampel yang digunakan accidental sampling dengan sebanyak 54 responden.  Jenis data yang digunakan adalah data primer. Analisa data yang digunakan yaitu analisa univariat dan analisa bivariat. Hasil penelitian menujukkan bahwa terdapat hubungan dukungan keluarga dengan kepatuhan minum obat pada pasien jiwa (p value = 0,001). Kesimpulan penelitian ini adalah terdapat hubungan dukungan keluarga dengan kepatuhan minum obat pada pasien jiwa di rumah sakit jiwa. Diharapkan kepada keluarga pasien selalu memperhatikan ketepatan dan kepatuhan dalam memberi minum obat dan dapat digunakan sebagai masukan dan informasi kepada keluarga, bahwa dukungan keluarga penting untuk meningkatkan kepatuhan minum obat pada pasien jiwa di rumah sakit jiwa Bina Karsa Medan Tahun 2020. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-07-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/120 10.36490/journal-jps.com.v5i2.120 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 201-204 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/120/88 Copyright (c) 2022 Maria Haryanti Butarbutar, Sri Lasmawanti, Ingkai Krisdayanti Purba, Herianto Bangun http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/122 2022-12-09T23:14:42Z jps:ART driver

TILAPIA (Oreochromis niloticus) BONE CREAM CREAM FORMULATION AS ANTI-AGING FORMULASI SEDIAAN KRIM KOLAGEN TULANG IKAN NILA (Oreochromis niloticus) SEBAGAI ANTI-AGING GINTING, ERNAWATY Zebua, Nilsya Febrika Khalisa, Khalisa Tilapia (Oreochromis niloticus) is a freshwater fish that has the highest production volume in Indonesia. Tilapia fish is exported in the form of fresh whole, frozen whole, fresh filet frozen filet. Collagen is one of the many protein derivatives found in bones. This study aims to determine whether tilapia bone collagen can be formulated in the form of a cream which in certain concentrations can provide an anti-aging effect and not irritate the skin. This study used an experimental method, using tilapia (Oreochromis niloticus) bones as test material. The stages of this study included sampling, determination of animals, isolation of collagen from tilapia bones, testing the characteristics of collagen with infrared spectrophotometry, selecting the basic cream formula, determining the modified cream formula, making tilapia bone collagen cream with concentrations of 1%, 1.5%, 2.5% and 3.5% and evaluation of cream preparations and anti-aging effectiveness tests using the Skin analyzer checker (aramo®) where the results were statistically tested using the ANOVA test with the SPSS 26 Free trial. The results showed that tilapia bone collagen (Oreochromis niloticus) can be formulated into cream preparations, is a homogeneous and stable preparation with an oil-in-water (O/A) emulsion type, with a pH range immediately after being made 6.1-6.5 and after cycling test 6.0-6.4. Tilapia fish bone collagen cream (Oreochromis niloticus) with a concentration of 3.5% (F4) showed the best anti-aging effectiveness in terms of providing moisture of 50.2%, included in the "moist" category with a percent recovery of 24.7%, more higher compared to the comparison cream which provides moisture of 47.0% including the "moisturizing" category with a recovery percentage of 16.14%, 21.5% reduction in pore size, 22.1% reduction in the number of blemishes and 22.2% reduction in the number of wrinkles . The results of the probability statistical test were smaller than (p<0.05) statistically showing a significant difference with the comparison cream. All preparations of tilapia bone collagen cream (Oreochromis niloticus) do not irritate the skin. Ikan nila (Oreochromis niloticus) merupakan ikan air tawar yang memiliki volume produksi terbanyak di Indonesia. Ikan nila diekspor dalam bentuk utuh segar, utuh beku, filet segar filet beku. Kolagen merupakan salah satu turunan protein yang banyak terdapat pada tulang. Penelitian ini bertujuan untuk mengetahui apakah kolagen tulang ikan nila dapat diformulasikan dalam bentuk krim yang dalam konsentrasi tertentu mampu memberikan efek anti-aging dan tidak mengiritasi kulit. Penelitian ini memakai metode eksperimental, menggunakan bahan uji tulang ikan nila (Oreochromis niloticus). Tahapan penelitian ini meliputi pengambilan sampel, determinasi hewan, isolasi kolagen dari tulang ikan nila, uji karateristik kolagen dengan spektrofotometri inframerah, pemilihan formula dasar krim, penetapan formula modifikasi krim, pembuatan krim kolagen tulang ikan nila dengan konsentrasi 1%, 1,5%, 2,5% dan 3,5% dan evaluasi sediaan krim serta uji efektivitas anti-aging menggunakan alat Skin analyzer checker (aramo®) dimana hasilnya di uji secara statistik memakai uji ANOVA dengan SPSS 26 Free trial. Hasil penelitian menunjukkan bahwa kolagen tulang ikan nila (Oreochromis niloticus) dapat di formulasikan kedalam sediaan krim, merupakan sediaan homogen dan stabil dengan tipe emulsi minyak dalam air (M/A), dengan rentang pH sesaat setelah dibuat 6,1-6,5 dan setelah cycling test 6,0-6,4. Sediaan krim kolagen tulang ikan nila (Oreochromis niloticus) dengan konsentrasi 3,5% (F4) menunjukkan efektivitas anti-aging yang paling baik dalam hal memberikan kelembaban sebesar 50,2% termasuk kategori “lembab” dengan persen pemulihan 24,7%, lebih tinggi dibandingkan dengan krim pembanding yang memberikan kelembaban sebesar 47,0% termasuk kategori “lembab” dengan persen pemulihan 16,14%, pengecilan besar pori 21,5%, pengurangan jumlah noda 22,1% dan pengurangan jumlah keriput sebesar 22,2% . Hasil uji statistik probabilitas lebih kecil dari (p<0,05) secara statistik menunjukkan perbedaan signifikan dengan krim pembanding. Seluruh sediaan krim kolagen tulang ikan nila (Oreochromis niloticus) tidak mengiritasi kulit. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-12-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/122 10.36490/journal-jps.com.v5i2.122 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 329-337 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/122/105 Copyright (c) 2022 Ernawaty Ginting, Nilsya Febrika Zebua, Khalisa http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/124 2023-06-22T01:16:56Z jps:ART driver

CREAM PREPARATION FORMULATION USING COLLAGEN BROILER CHICKEN BONE (Gallus gallus domestica) AS ANTI-AGING FORMULASI SEDIAAN KRIM MENGGUNAKAN KOLAGEN TULANG AYAM BROILER (Gallus gallus domestica) SEBAGAI ANTI-AGING GINTING, ERNAWATY Zebua, Nilsya Febrika Ridara, Rina Chicken bones are one type of solid waste that contains a source of protein in the form of collagen. Collagen is one of the main connective tissues of animal protein and is widely used as a biomedical material, and has anti-aging. Anti-aging in cream preparations can prevent aging of the skin. This study aims to determine whether broiler bone collagen can be formulated in cream preparations which at certain concentrations can provide anti-aging and do not irritate the skin. This research uses an experimental method, using broiler chicken bone test material. The stages of this research include isolation of collagen from broiler bones, characteristics of collagen with infrared spectrophotometry, manufacture of cream of broiler bone collagen with concentrations of 1%, 1.5%, 2.5% and 3.5% and evaluation of cream and testing the effectiveness of anti-aging agents. -aging using a skin analyzer (aramo) where the results are statistically tested using the ANOVA test with SPSS 26 free trial.  The results showed that broiler bone collagen can be formulated in cream anti-aging with an oil-in-water (O/W) emulsion type. Statistical test results show the probability is less than 0.05. The formulation of broiler chicken bone collagen cream with a concentration of 3.5% showed the best anti-aging by increasing moisture by 25.2%, reducing pores 22.2%, reducing blemishes 22.9% and reducing wrinkles 22.3%. Keywords : Broiler chicken, bone, collagen, anti-aging, cream Tulang ayam merupakan salah satu jenis limbah padat yang mengandung sumber protein berupa kolagen. Kolagen merupakan salah satu dari jaringan ikat utama protein hewani dan banyak digunakan sebagai bahan biomedis, dan memiliki efektivitas sebagai anti-aging. Anti-aging dalam sediaan krim mampu mencegah penuaan pada kulit. Penelitian ini bertujuan untuk mengetahui apakah kolagen tulang ayam broiler dapat diformulasikan dalam sediaan krim yang pada konsentrasi tertentu dapat memberikan efek anti-aging dan tidak mengiritasi kulit. Penelitian ini memakai metode eksperimental, menggunakan bahan uji tulang ayam broiler. Tahapan penelitian ini meliputi isolasi kolagen dari tulang ayam broiler, karakteristik kolagen dengan spektrofotometri inframerah, pembuatan krim kolagen tulang ayam broiler dengan konsentrasi 1%, 1,5%, 2,5% dan 3,5% dan evaluasi sediaan krim serta uji efektivitas anti-aging menggunakan alat skin analyzer (aramo) dimana hasilnya diuji secara statistik memakai uji ANOVA dengan SPSS 26 free trial. Hasil penelitian menunjukkan bahwa kolagen tulang ayam broiler dapat diformulasikan dalam sediaan krim anti-aging dengan tipe emulsi minyak dalam air (M/A) hasil evaluasi sediaan merupakan sediaan yang homogen, stabil dan tidak mengiritasi kulit dengan rentang pH 6,1-6,4. Hasil uji statistik menunjukkan probabilitas lebih kecil dari 0.05. Formulasi krim kolagen tulang ayam broiler dengan konsentrasi 3,5% menunjukkan efektivitas anti-aging yang terbaik dengan meningkatnya kelembaban 25,2%, mengurangi pori 22,2%, mengurangi noda 22,9% dan mengurangi keriput 22,3%. Kata Kunci : Ayam broiler, tulang, kolagen, anti-aging, krim Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-12-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/124 10.36490/journal-jps.com.v5i2.124 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 381-393 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/124/111 Copyright (c) 2022 Ernawaty Ginting, Nilsya Febrika Zebua, Rina Ridara http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/126 2022-09-13T09:52:13Z jps:ART driver

THE RELATIONSHIP BETWEEN NURSE THERAPEUTIC COMMUNICATIONS WITH BPJS PATIENT SATISFACTION ON INPATIENT INSTALLATIONS DURING THE COVID-19 PANDEMIC AT WULAN WINDY GENERAL HOSPITAL HUBUNGAN KOMUNIKASI TERAPEUTIK PERAWAT DENGAN KEPUASAN PASIEN BPJS DI INSTALASI RAWAT INAP SELAMA MASA PANDEMI COVID-19 DI RUMAH SAKIT UMUM WULAN WINDY Ilham, Muhammad Adiul Suharto, Teguh Therapeutic communication is communication in the health sector, one of which is in the field of nursing. Therapeutic communication is carried out by nurses and aims to help patients heal. Nursing services are basically aimed at providing satisfaction to patients. During the Covid-19 pandemic, patient safety in hospitals is a system where hospitals make patient care safer. Aim: to determine the relationship between nurse therapeutic communication and BPJS patient satisfaction on inpatient installations during the Covid-19 pandemic at Wulan Windy General Hospital in 2022. Methods: The research method used was quantitative with a cross-sectional approach. The research location is at Wulan Windy General Hospital. The study population was all inpatient BPJS patients at Wulan Windy General Hospital and a sample of 95 respondents. Sampling was done by accidental sampling. Results: It showed that the orientation stage variable has a p-value of 0.000 <0.05, the working stage with a p-value of 0.000 <0.05, and the termination stage with a p-value of 0.002 <0.05. Conclusion: there is a relationship between the variables of the orientation stage, work stage and termination stage with BPJS patient satisfaction during the Covid-19 pandemic with p sig < 0.05. It is recommended that nurses improve therapeutic communication with patients so that they can improve the quality of health services. Komunikasi terapeutik adalah komunikasi dalam bidang kesehatan salah satunya bidang keperawatan. Komunikasi terapeutik dilakukan oleh perawat dan bertujuan dalam membantu penyembuhan pasien. Pelayanan keperawatan pada dasarnya ditujukan untuk memberikan kepuasan kepada pasien. Pada masa pandemi Covid-19, keselamatan pasien (patient safety) di Rumah sakit adalah suatu sistem dimana Rumah Sakit membuat asuhan pasien lebih aman. Tujuan: untuk mengetahui hubungan komunikasi terapeutik perawat dengan kepuasan pasien BPJS di instalasi rawat inap selama masa pandemi Covid-19 di RSU Wulan Windy Tahun 2022. Metode: Metode penelitian yang digunakan adalah kuantitatif dengan pendekatan cross sectional. Lokasi penelitian di RSU Wulan Windy. Populasi penelitian seluruh pasien BPJS rawat inap di RSU Wulan Windy dan sampel sebanyak 95 orang. Penarikan sampel dilakukan dengan accidental sampling. Hasil: Menunjukkan bahwa variabel tahap orientasi memiliki nilai p-value 0,000<0,05, tahap kerja dengan p-value 0,000<0,05 dan tahap terminasi dengan p-value 0,002<0,05.  Kesimpulan: ada hubungan variabel tahap orientasi, tahap kerja dan tahap terminasi dengan kepuasan pasien BPJS selama masa pandemi Covid-19 dengan p sig < 0,05. Disarankan agar perawat lebih meningkatkan komunikasi terapeutik kepada pasien sehingga dapat meningkatkan kualitas pelayanan kesehatan Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-08-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/126 10.36490/journal-jps.com.v5i2.126 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 205-213 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/126/89 Copyright (c) 2022 Muhammad Adiul Ilham, Teguh Suharto http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/127 2022-09-13T09:52:13Z jps:ART driver

THE USE OF ORAL ANTIDIABETIC DRUGS IN OUTPATIENT TYPE 2 DIABETES MELLITUS AT A PRIVATE HOSPITAL, SAMARINDA. TERAPI PENGGUNAAN OBAT ANTIDIABETIK ORAL PADA PASIEN DIABETES MELITUS TIPE 2 RAWAT JALAN DI RUMAH SAKIT SWASTA, SAMARINDA. Linden, Susana Erwina, Wiwi Diabetes Mellitus is one of the most common conditions. Therefore, the management and selection of antidiabetic treatment should be a concern in installations providing therapy as primary health care providers, such as hospitals. This study was designed to examine the choice of using oral antidiabetic drugs (ADO) in general patients in the outpatient clinic of a private hospital in Samarinda. This study was conducted using a descriptive design in which data were collected retrospectively. Data were taken from general patient prescriptions in outpatient clinic of private hospitals in Samarinda in June 2022. The results showed that in June 2022 there were 8.30% single ADO therapy and 91.70% combined therapy. From the results of the study, it was found that the ADO drugs prescribed were the biaguanida (Metformin); sulfonylureas (glimepiride, gliclazide, gliquidone); acarbose; and a DPP-4 inhibitor (Vidagliptin). Overall, combination ADO therapy using two (2) drugs was found to be the most common in this study, as many as 182 cases (75.52%). The dominating combination was the combination of metformin and glimepiride, as many as 140 cases (58.09%). Diabetes Melitus merupakan salah satu kondisi yang sering ditemukan. Oleh karena itu, hendaklah tatalaksana dan pemilihan pengobatan antidiabetes menjadi perhatian di instalasi-instalasi pengadaan terapi sebagai penyedia layanan kesehatan primer, seperti rumah sakit. Penelitian ini disusun untuk mengkaji pemilihan penggunaan obat antidiabetik oral (ADO) pada pasien umum di instalasi rawat jalan rumah sakit swasta di Samarinda. Penelitian ini dilakukan dengan menggunakan rancangan deskriptif dimana data dikumpulkan secara retrospektif. Data diambil dari resep pasien umum di instalasi rawat jalan RS swasta di Samarinda pada bulan Juni 2022. Hasil penelitian menunjukkan pada bulan Juni 2022 terdapat 8,30% penggunaan terapi ADO tunggal dan 91,70% merupakan terapi kombinasi. Dari hasil penelitian diperoleh obat ADO yang diresepkan adalah golongan biaguanida (Metformin); sulfonilurea (glimepiride, gliclazide, gliquidone); acarbose; dan penghambat DPP-4 (Vidagliptin). Secara keseluruhan, terapi ADO dengan kombinasi menggunakan dua (2) obat ditemukan paling banyak dalam penelitian ini, sebanyak 182 kasus (75,52%). Kombinasi yang mendominasi adalah kombinasi antara metformin dan glimepiride, sebanyak 140 kasus (58,09 %). Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-08-31 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/127 10.36490/journal-jps.com.v5i2.127 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 2014-226 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/127/90

oai:ojs2.journal-jps.com:article/129 2023-06-22T01:16:56Z jps:ART driver

ANTIOXIDANT ACTIVITY TESTING OF MANGGOST (Garcinia mangostana L.) SKIN EXTRACT IN SERUM PREPARATION WITH DPPH METHOD UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL KULIT BUAH MANGGIS (Garcinia mangostana L.) DALAM SEDIAAN SERUM DENGAN METODE DPPH maulina, syarifah nadia Zebua, Nilsya Febrika salsabila, dafitri Mangosteen rind has antioxidant compounds that can counteract free radicals. Serum is a liquid enriched with active ingredients such as antioxidants that are able to penetrate into the facial skin. This research used experimental method, using mangosteen rind test material (Garcinia mangostana L.) which was obtained by extraction method using ethanol pa. The stages of this research include the manufacture of extracts from mangosteen rind and formulated into serum preparations in several concentrations, namely 3%, 4%, 5%, blank and continued with physical quality examination of the preparation. The results of the homogeneity test showed that all serum preparations were homogeneous. The pH test results showed a pH of 6.0-6.4. Viscosity test results show 1268-1870 mPa's. The results of the stability test showed that all preparations were stable. The results of the irritation test showed that all preparations were not irritating. The results of the preference test showed that the F2 preparation with a concentration of 4% was the most preferred. The preparation with the best concentration was 5% (F3) with an IC50 value of 31.92 ppm. This proves that the antioxidant activity of the mangosteen rind extract serum is very strong. Keywoard : Mangosteen Peel, Serum, Antioxidants Kulit buah manggis memiliki senyawa antioksidan yang dapat menangkal radikal bebas. Serum adalah cairan yang diperkaya bahan aktif seperti antioksidan yang mampu menembus kedalam kulit wajah. Penelitian ini menggunakan metode eksperimental, dengan menggunakan bahan uji kulit buah manggis (Garcinia mangostana L.) yang diperoleh dengan cara metode ekstraksi menggunakan etanol pa. Tahapan penelitian ini meliputi pembuatan ekstrak dari kulit buah manggis dan diformulasikan kedalam sediaan serum dalam beberapa konsentrasi yaitu 3%, 4%, 5%, blanko dan dilanjutkan dengan pemeriksaan mutu fisik sediaan. Hasil uji homogenitas menunjukkan bawa semua sediaan serum homogen. Hasil uji pH menunjukkan pH 6,0-6,4. Hasil uji viskositas menunjukkan 1268-1870 mPa’s. Hasil uji stabilitas menunjukkan bahwa semua sediaan stabil. Hasil uji iritasi menunjukkan bahwa semua sediaan tidak mengiritasi. Hasil uji kesukaan menunjukkan bahwa sediaan F2 konsentrasi 4% paling banyak disukai. Sediaan dengan konsentrasi paling baik adalah 5% (F3) dengan nilai IC50 sebesar 31,92 ppm. Hal ini membuktikan bahwa aktifitas antioksidan dari sediaan serum ekstrak kulit buah manggis tergolong sangat kuat. Kata kunci : Kulit Buah Manggis, Serum, Antioksidan Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-12-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/129 10.36490/journal-jps.com.v5i2.129 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 372-380 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/129/110 Copyright (c) 2022 syarifah nadia maulina, Nilsya Febrika Zebua, dafitri salsabila http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/131 2023-06-22T01:16:56Z jps:ART driver

ANTIOXIDANT ACTIVITY TEST OF TELANG FLOWER (Clitoria ternatea L.) IN SERUM PREPARATION WITH DPPH METHOD UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL BUNGA TELANG (Clitoria ternatea L.) DALAM SEDIAAN SERUM DENGAN METODE DPPH maulina, syarifah nadia sihotang, supran hidayat mukharomah, SITI ABSTRACT Telang flower (Clitoria ternatea L.) is a plant that contains flavonoid compounds with very high antioxidant activity. Antioxidants have small molecular weights that are able to counteract the formation of free radicals in the body so that they can inhibit cell damage. This study used an experimental method, using the test material of telang flower (Clitoria ternatea L.) by maceration using pro-analytical ethanol as solvent. This study begins with sample preparation which includes plant sampling, identification of telang flower plants (Clitoria ternatea L.), phytochemical screening, then processing of simplicia powder, making ethanol extract, selecting the basic formula for serum preparations, determining the formulation of modified serum bases and making serum preparations of telang flower ethanol extract (Clitoria ternatea L.) in various dosage concentrations, namely 3%; 4%; 5%; and blanks, physical quality checks and antioxidant activity tests. The results showed that telang flower (Clitoria ternatea L.) in the form of ethanol extract can be formulated into serum dosage forms, is a homogeneous, stable and non-irritating preparation of the skin with a pH range shortly after being made 5.9-6.1 and pH after testing. stability (Cycling test) 5.4-5.7.                                                                                      Keywoard :Clitoria ternatea L.; telang flower; serum; antioxidant; DPPH Bunga telang (Clitoria ternatea L.) merupakan salah satu tanaman yang mengandung senyawa flavonoid dengan aktivitas antioksidan yang sangat tinggi. Antioksidan memiliki berat molekul kecil yang mampu menangkal terbentuknya radikal bebas didalam tubuh sehingga dapat menghambat kerusakan sel. Penelitian ini menggunakan metode eksperimental, dengan menggunakan bahan uji bunga telang (Clitoria ternatea L.) dengan cara maserasi menggunakan pelarut etanol pro analisis. Penelitian ini diawali dengan penyiapan sampel yang meliputi, pengambilan sampel tumbuhan, identifikasi tumbuhan bunga telang (Clitoria ternatea L.), skrining fitokimia, kemudian dilakukan pengolahan serbuk simplisia, pembuatan ekstrak etanol, pemilihan formula dasar sediaan serum, penetapan formulasi modifikasi dasar serum dan pembuatan sediaan serum ekstrak etanol bunga telang (Clitoria ternatea L.) dalam berbagai konsentrasi sediaan yaitu 3%; 4%; 5%; dan blanko, pemeriksaan mutu fisik dan uji aktivitas antioksidan. Hasil penelitian menunjukkan bahwa bunga telang (Clitoria ternatea L.)  dalam bentuk ekstrak etanol dapat diformulasikan kedalam bentuk sediaan serum, merupakan sediaan yang homogen, stabil dan tidak mengiritasi kulit dengan rentang pH sesaat setelah dibuat 5,9-6,1 dan pH setelah pengujian kestabilan (Cycling test) 5,4-5,7.   Kata kunci :Clitoria ternatea L.; bunga telang; serum; antioksidan; DPPH Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-12-10 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/131 10.36490/journal-jps.com.v5i2.131 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 394-403 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/131/112 Copyright (c) 2022 syarifah nadia maulina, supran hidayat sihotang, SITI mukharomah http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/132 2022-12-09T23:14:42Z jps:ART driver

ANTIOXIDANT ACTIVITY LEAVES OF MENGKUDU (Morinda Citrifolia L.) SKIN EXTRACT IN SERUM PREPARATION WITH DPPH METHOD UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) DALAM SEDIAAN SERUM DENGAN METODE DPPH maulina, syarifah nadia sari, nurmala hamsi, fadhillah The leaves of mengkudu is a native plant from Indonesia that contains flavonoid compounds that have antioxidant activity so that is beneficial for the skin. This research was conducted using the escperimental method and used test materials  for ethanol extract of the leaves of the subdued by the maceration method, formulated into serum preparations in various concentrations, namely 3%, 4%, 5% and blanks, and physical quality examination of the preparations. The results of the ph test showed a ph 6,3-6,5. Serum bath results at an F3 concentration (5%) which is the preferred (best) preparation. The results of the 6% moisture content test, the results of obtaining 10,3% leaf extract. It has antioxidant activity including the (strong) category with an IC50 value of 50.40. Testing the antioxidant activity of the ethanol extract of the leaves of mengkudu (morinda citrifolia L.) belongs to the category (very strong) with an IC50 value 44.27 μg / mL, the antioxidant activity of the blanks of serum preparations including the category (inactive) with an IC50 value of 676.49 μg / mL, and all serums of this purifying leaf extract do not cause irritation to the skin.   Daun mengkudu (Morinda citrifolia L.) Merupakantanamanaslidariindonesia yang mengandungsenyawa flavonoid yang memilikiaktivitasantioksidansehinggabermanfaatuntukkulit. Penelitian ini dilakukan dengan  metode eskperimental dan menggunakan bahan uji ekstrak etanol daun mengkudu dengan metode maserasi, diformulasikan kedalam sediaan serum dalam berbagai konsentrasi yaitu 3%, 4%, 5% serta blanko, dan pemeriksaan mutu fisik sediaan. Hasil homogenitas sediaan menunjukan semua homogeny. Hasil uji ph menunjukan ph 6,3-6,5. Hasil sediaan serum pada konsentrasiF3 (5%) yang merupakan sediaan yang disukai (terbaik). Hasil dari uji kadar air 6%, hasil perolehan ekstrak daun mengkudu 10,3%. Memiliki aktivitas antioksidan termasuk katagori (kuat) dengan nilai IC50 50,40. Pengujian aktivitas antioksidan ekstrak etanol daun mengkudu (morinda citrifolia L.) termasuk katagori (sangat kuat) dengan nilai IC50  44,27 µg/mL, aktivitas antioksidan blanko sediaan serum termasuk katagori (tidak aktif) dengan nilai IC50 676,49 µg/mL, dan semua sedian serum ekstrak daun mengkudu ini tidak menyebabkan iritasi pada kulit Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-12-09 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/132 10.36490/journal-jps.com.v5i2.132 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 346-354 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/132/107 Copyright (c) 2022 syarifah nadia maulina, nurmala sari, fadhillah hamsi http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/133 2022-09-23T15:19:54Z jps:ART driver

THE EFFECT OF THE EFFECTIVENESS OF INFANT MASSAGE ON INCREASING THE DURATION OF NIGHT SLEEP IN INFANTS 0-3 MONTHS PENGARUH EFEKTIFITAS PIJAT BAYI TERHADAP PENINGKATAN LAMANYA TIDUR MALAM PADA BAYI 0-3 BULAN Siregar, Riani Baiduri Siregar, Harryjun K This research is a pre-experimental using a one-group pre-test – post-test design with the aim of knowing directly the effect of giving a baby massage on the length of sleep babies at night in infants aged 0-3 months before treatment and after treatment in one group. The research subjects were 10 infants who met the inclusion criteria. Hypothesis testing was carried out using a paired sample t-test. This analysis was used to test two groups of dependent data with interval or ratio data scales. The provisions of the hypothesis testing failed to be rejected if p < (0.05). The results of the hypothesis test using the paired sample t-test obtained a significant value of p = 0.003 where p < (0.05), which means that there is an effect of giving a baby massage to the increase in length of time. night sleep in infants aged 0-3 months before and after massage. From the results of the study, it can be concluded from these data that there is an effect of giving baby massage to increase the length of night sleep in infants aged 0-3 months after massage. Penelitian ini merupakan pre-eksperimental dengan menggunakan one group pretest – posttest design dengan tujuan untuk mengetahui secara langsung efek pemberian pijat bayi terhadap lamanya tidur bayi di malam haripada bayi usia 0-3 bulan pada saat sebelum perlakuan dengan sesudah perlakuan pada satu kelompok. Subjek penelitian sejumlah 10 orang bayi yang memenuhi kriteria inklusi.Pengujian Hipotesa dilakukan dengan menggunakan paired sample t test, Analisis ini digunakan untuk menguji dua kelompok data dependent dengan skala data interval atau rasio. Dengan ketentuan pengujian  Hipotesa gagal ditolak bila  p < α (0,05).Hasil uji Hipotesa dengan menggunakan paired sample t-test diperoleh nilai significant p = 0,003 dimana p < α (0,05),  yang artinya ada efek pemberian pijat bayi terhadap peningkatan lama tidur malam hari pada bayi usia 0-3 bulan sebelum dan sesudah pemijatan.Dari hasil penelitian dapat diambil kesimpulan dari data tersebut bahwa  ada efek pemberian pijat bayi terhadap peningkatan lama tidur malam hari pada bayi usia 0-3 bulan sesudah pemijatan. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-08-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/133 10.36490/journal-jps.com.v5i2.133 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 227-232 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/133/91 Copyright (c) 2022 Riani Baiduri Siregar, Harryjun K Siregar http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/134 2022-12-03T14:16:00Z jps:ART driver

ACTIVITY TEST OF ETHANOL EXTRACT OF JERINGAU RHIZOME (Acorus Calamus L.) AS ANTIBACTERIAL AGAINST of Staphylococcus aureus AND Escherichia coli UJI AKTIVITAS EKSTRAK ETANOL RIMPANG JERINGAU (Acorus calamus L.) SEBAGAI ANTIBAKTERI TERHADAP Staphylococcus aureus DAN Escherichia coli Misrahanum, Misrahanum Fitri, Ramadayani Ismail, Yulia Sari Jeringau rhizome (Acorus calamus L.) have the potency to be an antibacterial. This research aimed to find the activity of the ethanol extract of jeringau rhizome on the growth of Staphylococcus aureus and Escherichia coli bacteria. This research utilized an experimental method of maceration with ethanol solvent, phytochemical screening, and activity testing with concentrations of 2,5; 5; 10; 15, and 20% using a well diffusion method. The phytochemical screening shows that the extract contains compounds of alkaloids, tannins, flavonoids, saponins, and triterpenoids. The activity test has shown that the jeringau rhizome extract could obstruct the growth of bacteria from the lowest concentration of 2,5% on 6,86 mm of S. aureus and 7,36 mm on E. coli. The largest restrictive zone was at 20% concentration with a 10,73 mm diameter of S. aureus and 12,63 mm of E. coli. Rimpang jeringau (Acorus calamus L.) berpotensi sebagai antibakteri. penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol rimpang jeringau terhadap pertumbuhan bakteri S.aureus dan E.coli. Penelitian menggunakan metode eksperimental ,ekstraksi secara maserasi, skrining fitokimia dan uji aktivitas pada konsentrasi 2,5; 5; 10; 15 dan 20%, dengan metode sumuran. Skrining fitokimia menunjukkan kandungan senyawa alkaloid, tanin, flavonoid, saponin dan triterpenoid. Ekstrak rimpang jeringau menghambat pertumbuhan bakteri mulai dari konsentrasi terkecil yaitu 2,5%, terhadap S. aureus 6,86 mm dan E. coli 7,36 mm. Zona hambat terbesar pada konsentrasi 20% dengan diameter 10,73 mm terhadap S. aureus sedangkan pada E. coli 12,63 mm. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-12-02 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/134 10.36490/journal-jps.com.v5i2.134 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 294-300 2656-3088 10.36490/journal-jps.com.v5i2 eng https://www.journal-jps.com/index.php/jps/article/view/134/100 Copyright (c) 2022 Misrahanum Misrahanum, Ramadayani Fitri, Yulia Sari Ismail http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/135 2022-11-28T23:45:46Z jps:ART driver

Administrative, Pharmaceutical and Clinical Studies Prescription of Antihypertensive Drugs in One of the Pharmacies in Medan City for the Period October - December 2020 Kajian Administratif, Farmasetis dan Klinis Resep obat antihipertensi di salah satu apotek di Kota Medan periode oktober – desember 2020 rusliza, vira Neswita, Elfia Razoki, Razoki Hypertension is a disease in which a person experiences an increase in blood pressure above standard limits, which can increase morbidity (morbidity) and death (mortality). Hypertension, this figure is likely to increase to 29.2% in 2025. This study uses a descriptive research method with a retrospective design, namely research by reviewing information or taking past data. This data was obtained from pharmacies' antihypertensive prescriptions for October–December 2020. Research on this prescription study was conducted on 46 antihypertensive drug prescriptions in October-December 2020 at pharmacies, while in October, there were 14 drug prescriptions, and in November, 16 drug prescriptions. , in December, as many as 16 prescription drugs. They observed the completeness of prescriptions based on administrative, pharmaceutical and clinical prescribing studies. The study of this recipe used parameters in the form of prescription writing guidelines, namely PERMENKES RI No. 73 of 2016, concerning the standard of pharmaceutical services in pharmacies. Many prescriptions were found not following the Regulation of the Minister of Health of Indonesia Number 73 of 2016 concerning the standards of pharmaceutical services in pharmacies. In the administrative study, only four patient prescriptions were obtained that matched the pattern of using antihypertensive drugs. While in the pharmaceutical study, 46 patient prescriptions had met the pattern of using antihypertensive drugs. Furthermore, in clinical studies, eight prescriptions met the pattern of antihypertensive drug use. The average interaction obtained from using antihypertensive drugs at the pharmacy is minor. Tekanan darah tinggi atau hipertensi, adalah kondisi medis yang dapat menyebabkan komplikasi kesehatan yang serius dan bahkan kematian jika tidak diobati (kematian). Hipertensi, diperkirakan pada tahun 2025 akan meningkat menjadi sekitar 29,2% penduduk akan mengidapnya. Pendekatan deskriptif diambil dalam hubungannya dengan desain penelitian retrospektif untuk mengumpulkan data untuk penelitian ini. Data ini diperoleh dari resep antihipertensi periode Oktober–Desember 2020 di Apotek Penelitian tentang kajian resep ini dilakukan terhadap 46 lembar resep obat antihipertensi pada bulan Oktober-Desember 2020 di Apotek, adapun pada bulan Oktober sebanyak 14 resep obat, pada bulan November sebanyak 16 resep obat, pada bulan Desember sebanyak 16 resep obat. Dengan mengamati kelengkapan resep, berdasarkan kajian administratif, farmasetis dan klinik resep obat. Pada pengkajian resep ini digunakan parameter berupa pedoman penulisan resep yaitu PERMENKES RI No. 73 tahun 2016 tentang standar pelayanan kefarmasian di Apotek.banyak ditemukan resep yang belum sesuai dengan Peraturan Menteri Kesehatan Indonesia Nomor 73 tahun 2016 Tentang standar pelayanan kefarmasian di Apotek. Pada kajian administratif, hanya diperoleh sebanyak 4 resep pasien yang sudah sesuai pola penggunaan obat anti hipertensi. sedangkan dikajian farmasetis, ada 46 resep pasien yang sudah memenuhi pola penggunaan obat antihipertensi. dan pada kajian klinis, terdapat 8 resep yang memenuhi pola penggunaan obat antihipertensi. Rata-rata interaksi yang didapatkan dari hasil penggunaan obat anti hipertensi di Apotek tersebut yaitu itu interaksi secara minor. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-11-16 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/135 10.36490/journal-jps.com.v5i2.135 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 233-239 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/135/92 Copyright (c) 2022 Vira Rusliza, Elfia Neswita, Razoki Lubis http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/139 2022-12-03T14:16:00Z jps:ART driver

Isolation of Escherichia coli in Raw Water Sources and Resistance Assay for Ampicillin and Ceftriaxone Isolasi Escherichia coli pada Sumber Air Baku serta Uji Resistensinya Terhadap Antibiotik Ampisilin dan Seftriakson Suparno, Adinda Christianti Kasasiah, Ahsanal Ratnasari, Devi Citarum river pollution by fecal Coliform (Escherichia coli) is relatively high. Based on the results of monitoring in 2010 showed that the amount of E. coli in several areas drained by the Citarum river exceeded the Water Quality Limit (BMA), which was >1.000/100 ml. Citarum river irrigation is a source of raw water for one of the IPAM in Karawang, which is the source for most of the fulfillment of clean water for daily needs. E. coli can infect through water contamination so this condition can trigger the spread of the disease in the community. Diseases caused by bacterial infections are often treated with antibiotics. The use of antibiotics has increased tremendously in the last 5 decades, resulting in selective solid pressure and potentially triggering resistance in bacteria. This study aims to isolate E. coli and test its resistance to ampicillin and ceftriaxone antibiotics. The methods used in this study include presumptive test, confirmation test, Gram staining, and resistance testing using the Kirby-Bauer method, with the standard used in categorization referring to CLSI 2020. The results showed that E. coli isolates were still sensitive to ampicillin and ceftriaxone antibiotics with an inhibition zone of 26,16 mm and 33,27 mm. Pencemaran sungai Citarum oleh Coliform fecal (Escherichia coli) cukup tinggi. Berdasarkan hasil monitoring pada tahun 2010 menunjukkan bahwa jumlah E.coli di beberapa daerah yang dialiri oleh sungai Citarum melebihi Batas Mutu Air (BMA) yaitu > 1.000/100 ml. Irigasi sungai Citarum merupakan sumber air baku bagi salah satu IPAM di Karawang, yang merupakan sumber bagi sebagian besar pemenuhan air bersih bagi kebutuhan sehari-hari.  E.coli dapat menginfeksi melalui kontaminasi air, sehingga dikhawatirkan kondisi ini dapat memicu penyebaran penyakit di masyarakat.  Penyakit yang disebabkan oleh infeksi bakteri sering diobati dengan antibiotik. Pemakaian antibiotik telah mengalami peningkatan yang luar biasa selama 5 dekade terakhir sehingga mengakibatkan tekanan selektif yang kuat dan berpotensi memicu kejadian resistensi pada bakteri. Penelitian ini bertujuan untuk mengisolasi E.coli serta menguji resistensinya terhadap antibiotik ampisilin dan seftriakson. Metode yang digunakan dalam penelitian ini meliputi uji pendugaan, uji penegasan, pewarnaan Gram dan pengujian resistensi menggunakan metode Kirby-Bauer dengan standar yang digunakan dalam melakukan kategorisasi mengacu pada CLSI 2020. Pada hasil penelitian didapatkan isolat E.coli yang kemudian dilakukan pengujian resistensi dengan hasil masih sensitif terhadap antibiotik ampisilin dan seftriakson dengan zona hambat masing-masing 26,16 mm dan 33,27 mm. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/139 10.36490/journal-jps.com.v5i2.139 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 265-273 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/139/96 Copyright (c) 2022 Adinda Christianti Suparno, Ahsanal Kasasiah, Devi Ratnasari http://creativecommons.org/licenses/by-nc-sa/4.0

oai:ojs2.journal-jps.com:article/140 2022-12-03T14:16:00Z jps:ART driver

Comparison of Antibacterial of Sambiloto (Andrographis paniculata) Leaf and Kemangi (Ocimum sanctum) Leaf Extract Against Staphylococcus aureus Perbandingan Antibakteri Ekstrak Daun Sambiloto (Andrographis paniculata) dan Daun Kemangi (Ocimum sanctum) terhadap Pertumbuhan Bakteri Staphylococcus aureus Sholihah, Nisrina Fauziyah Saula, Lely Sulfiani Sholih, Mally Ghinan Sambiloto leaf (Andrographis paniculata) and kemangi leaf (Ocimum sanctum) are alternatives that can be used in medicine as antibacterial. Staphylococcus aureus is a pathogen for the human body that can be treated with antibiotics. However, antibiotic resistance can occur if its use is not appropriate. So, alternative treatments with plants are used as essential therapeutic ingredients that have the potential as drugs. The purpose was to identify and analyze the antibacterial combination of sambiloto leaf extract and kemangi against the growth of Staphylococcus aureus bacteria. The extract was obtained by maceration method using 96% ethanol and tested for antibacterial activity using the diffusion method with various concentrations of 6.25% to 100% and tested at combination concentrations (50%:50%), (75%:25%), and (25%:75%). The concentration of sambiloto leaf at 80% and kemangi leaf at 6.25% were the outcomes of the optimal inhibitory zone generated in the extract. In the combination test, a concentration of 75%: 25% with an average diameter of 26.80. The p-value of the One-Way ANOVA test is 0.001, be concluded that each extract concentration affects bacterial growth. The conclusion is that the extracts of sambiloto leaves and kemangi were able to inhibit the growth of Staphylococcus aureus bacteria. Daun sambiloto (Andrographis paniculata) dan daun kemangi (Ocimum sanctum) merupakan tumbuhan alternatif yang dapat digunakan dalam pengobatan sebagai zat antibakteri. Staphylococcus aureus dapat menjadi bakteri patogen bagi tubuh manusia, pengobatannya dapat diberikan antibiotik. Namun resisten antibiotik dapat terjadi bila penggunaannya tidak tepat. Sehingga digunakan alternatif pengobatan dengan tanaman sebagai bahan dasar terapi yang memiliki potensi sebagai obat. Tujuan penelitian ini yaitu mengidentifikasi dan menganalisa kombinasi antibakteri dari ekstrak daun sambiloto dan daun kemangi terhadap pertumbuhan bakteri Staphylococcus aureus. Ekstrak diperoleh dengan metode maserasi menggunakan etanol 96% dan diuji aktivitas antibakteri menggunakan metode difusi dengan berbagai konsentrasi dari 6,25% hingga 100%, serta diujikan pada kombinasi konsentrasi dengan perbandingan (50% 50%), (75%:25%), dan (25%:75%). Hasil zona hambat optimum yang terbentuk pada ekstrak yaitu konsentrasi daun sambiloto 80% dan daun kemangi 6,25%. Pada pengujian kombinasi kedua ekstrak konsentrasi 75%:25% dengan rata-rata diameter yaitu 26,80.  Hasil p-value pengujian One-Way ANOVA yaitu 0,001, dapat disimpulkan terdapat pengaruh setiap konsentrasi ekstrak terhadap pertumbuhan bakteri. Kesimpulan dari penelitian ini yaitu ekstrak daun sambiloto dan daun kemangi mampu menghambat pertumbuhan bakteri Staphylococcus aureus. Fakultas Farmasi Universitas Tjut Nyak Dhien 2022-11-30 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://www.journal-jps.com/index.php/jps/article/view/140 10.36490/journal-jps.com.v5i2.140 Journal of Pharmaceutical And Sciences; Vol 5 No 2 (2022): JPS Volume 5 Nomor 2 (2022); 279-285 2656-3088 10.36490/journal-jps.com.v5i2 ind https://www.journal-jps.com/index.php/jps/article/view/140/98 Copyright (c) 2022 Nisrina Fauziyah Sholihah, Lely Sulfiani Saula, Mally Ghinan Sholih http://creativecommons.org/licenses/by-nc-sa/4.0 04af01ee9a7b8b62a03197f1b71231aa